Beclin-1-like protein 1 antibody
Principal name
Beclin-1-like protein 1 antibody
Alternative names for Beclin-1-like protein 1 antibody
BECN1L1, Beclin 2
SwissProt ID
A8MW95 (Human)
Ncbi ID
Available reactivities
Available hosts
Available applications
Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P)
Background of Beclin-1-like protein 1 antibody
Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells (1,2). Beclin 2 is a mammalian specific homolog of the autophagy protein Beclin 1 (3). Like Beclin 1, Beclin 2 interacts with Bcl-2 and class III PI3K complex components. However, Beclin 2 functions in an additiol lysosomal degradation pathway and is required for ligand-induced endolysosomal degradation of several G protein-coupled receptors (3). Beclin 2 is also required for agonist-induced lysosome-mediated degradation of EGFR in lung cancer cells, suggesting that it may also play a role in regulating other intracellular sigling pathways (4).
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| TA349109 | Beclin-1-like protein 1 antibody |
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| Rabbit Polyclonal Anti-Beclin 2 Antibody | |||||||
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Rabbit | IgG | Purified | Hu | ICC/IF, P, WB |
0.1 mg /
€325.00
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| OriGene Technologies, Inc. | |||||||
 +2 additional images |
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