Beta-2 adrenergic receptor antibody

Principal name

Beta-2 adrenergic receptor antibody

Alternative names for Beta-2 adrenergic receptor antibody

ADRB2, ADRB2R, B2AR, Beta-2 adrenoreceptor

SwissProt ID

P07550 (Human), P10608 (Rat), P18762 (Mouse), P54833 (Canfa), Q28044 (Bovin)

Gene ID

154 (ADRB2), 11555 (Adrb2)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Rt (Rat), GP (Guinea Pig), Can (Canine), Sh (Sheep), Por (Porcine), Mky (Monkey), Prim (Primate)

Available hosts

Rabbit, Goat, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Flow Cytometry (F), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Dot blot (Dot), Immunoprecipitation (IP), Functional assay (FN)

Background of Beta-2 adrenergic receptor antibody

Adrenoceptors (also called adrenergic receptors) are the receptors for the catecholamines adreline and noradreline (called epinephrine and norepinephrine in the United States). Adreline and noradreline play important roles in the control of blood pressure, myocardial contractile rate and force, airway reactivity, and a variety of metabolic and central nervous system functions. The Adrenoceptors are members of the G-protein-coupled receptor (GPCR) superfamily of membrane proteins. They share a common structure of seven putative transmembrane domains, an extracellular amino terminus, and a cytoplasmic carboxyl terminus.The Adrenoceptors are divided into three types: a1, a2 and Ã? Adrenoceptors. Each type is further divided into at least three subtypes: a1A, a1B, a1D, a2A, a2B, a2C, Ã?1, Ã?2, Ã?3. The Adrenoceptors are expressed in nearly all peripheral tissues and in the central nervous system. Ã?2-Adrenoceptors are mainly postsyptic receptors. They are expressed on a number of tissues including blood vessels, bronchi, gastrointestil tract (GIT), skeletal muscle, liver and mast cell. Functiol Ã?2-Adrenoceptors were also found on lymphocytes, macrophages and neutrophils. They are also the only Ã?2-Adrenoceptors subtype expressed in keratinocytes, fibroblasts and melanocytes. Activation of Ã?2-Adrenoceptors results in vasodilation, relaxation of the GIT, inhibition of histamine release from mast cells and bronchodilation. Selective agonists of Ã?2-Adrenoceptors are used to treat asthma and other related bronchospastic conditions such as Chronic obstructive pulmory disease (COPD).

General readings

1. Rekawiecki R, Nowocin A, Kotwica J. Relationship between concentrations of progesterone, oxytocin, noradrenaline, gene expression and protein level for their receptors in corpus luteum during estrous cycle in the cow. Prostaglandins Other Lipid Mediat. 2010 Jun;92(1-4):13-8.
PMID: 20149890

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Lysates

Catalog No.    

ADRB2 overexpression lysate

ADRB2 overexpression lysate  
0.1 mg / €295.00
  OriGene Technologies, Inc.

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