Beta-3 adrenergic receptor antibody

Principal name

Beta-3 adrenergic receptor antibody

Alternative names for Beta-3 adrenergic receptor antibody

ADRB3, ADRB3R, B3AR, Beta-3 adrenoceptor

SwissProt ID

O02662 (Canfa), P13945 (Human), P25962 (Mouse), P26255 (Rat), P46626 (Bovin)

Gene ID

155 (ADRB3), 11556 (Adrb3), 25645

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey), GP (Guinea Pig)

Available hosts

Goat, Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Flow Cytometry (F), Paraffin Sections (P)

Background of Beta-3 adrenergic receptor antibody

The Beta-3 Adrenoceptor (ADRB3) is an Adrenergic Receptor that stimulates lipolysis and increases fatty acids in the blood. Stimulation of the beta-3 adrenoceptor leads to lipolysis in white adipocytes and nonshivering thermogenesis in brown fat. The beta-3 adrenoceptor has also been suggested to affect the physiological control of cardiac and vascular contractility; beta-3 adrenoceptor stimulation decreases cardiac contractility through activation of a nitric oxide synthase pathway.
A variant of the beta-3 adrenoceptor, Trp64Arg, has been shown to be associated with weight gain (obesity) and susceptibility to non-insulin-dependent diabetes mellitus (NIDDM), but not with coronary artery disease. Trp64Arg variant receptor has been shown to predict a greater tendency to develop abdominal adiposity and high blood pressure with advancing age. ADRB3 has been suggested to be responsible for the negative inotropic effects of catecholamines and may be involved in pathophysiological mechanisms leading to heart failure; ADRB3 is also one of the molecular targets under active research in the treatment of obesity.
Beta-3 adrenoceptor expression has been documented in adipose, heart, and in smooth muscle of digestive and urinary tract organs (bladder, colon, small intestine, stomach, ureter). Utilization of alternate promoters and/or 3-prime untranslated regions may result in tissue-specific regulation of the expression of ADRB3. ESTs have been isolated from heart/melanocyte/uterus and placenta libraries.

General readings

Pierola J, Barcelo A, de la Pena M, Barbe F, B Soriano J, S Armengol A, Martinez C, Agusti A.
THE Trp64Arg polymorphism of the beta (3) adrenergic receptor is associated with increased body mass index in patients with sleep apnoea.
Eur Respir J. 2007 Jul 11
PMID: 17626108

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Beta-3 adrenergic receptor antibody

  Goat Polyclonal Antibody against ADRB3  
TA303277 (0.03µg/ml) staining of Human Brain (Cerebral Cortex) lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Beta-3 adrenergic receptor antibody

  Rabbit polyclonal anti-ADRB3 antibody  
Western blot analysis of extracts from K562 cells, using ADRB3 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Beta-3 adrenergic receptor (Cytopl. Dom.) antibody

  ADRB3 Rabbit Polyclonal (C-Terminus) Antibody  
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Aff - Purified Hu, Mky P
50 µg / €400.00
  OriGene Technologies, Inc.

Beta-3 adrenergic receptor (N-term) antibody

  ADRB3 Rabbit Polyclonal (N-Terminus) Antibody  
Anti-ADRB3 antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified GP, Hu, Ms, Rt P
50 µg / €400.00
  OriGene Technologies, Inc.

Beta-3 adrenergic receptor antibody

  Anti-ADRB3 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm, Cell membrane. Positive control: Human cervical cancer tissue. Recommended dilution: 1/50-100  The image on the left is immunohistochemistry of paraffin-embedded human cervical cancer tissue using ADRB3 antibody at dilution 1/60, on the right is treated with the synthetic peptide. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Beta-3 adrenergic receptor antibody

  Anti-ADRB3 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm, Cell membrane. Positive control: Human gastric cancer tissue. Recommended dilution: 1/15-50  The image on the left is immunohistochemistry of paraffin-embedded human gastric cancer tissue using ADRB3 antibody at dilution 1/20, on the right is treated with the synthetic peptide. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Beta-3 adrenergic receptor antibody

  Rabbit Polyclonal Anti-beta3-Adrenoceptor (extracellular)  
Western blot analysis of mouse brain (lanes 1 and 3) and rat brain (lanes 2 and 4) lysates: 1, 3. Anti-ß3-Adrenoceptor (extracellular) antibody, (1:200). 2, 4. Anti-ß3-Adrenoceptor(extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Beta-3 adrenergic receptor antibody

  Rabbit Polyclonal Anti-ADRB3 Antibody  
Beta-3 adrenergic receptor Rabbit IgG Purified Hu E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Beta-3 adrenergic receptor antibody

Western blot (WB) analysis of AR-β3 antibody (Cat.-No.: AP01420PU-N) in extracts from K562 cells. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Beta-3 adrenergic receptor antibody

Western blot analysis of extracts from K562 cells, using ADRB3 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
50 µg / €230.00
  Assay Biotech

Beta-3 adrenergic receptor antibody

Western blot analysis of extracts from K562 cells, using ADRB3 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

ADRB3 - human gene knockout kit via CRISPR

ADRB3 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

ADRB3 - human gene knockout kit via CRISPR

ADRB3 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

ADRB3 - human gene knockout kit via CRISPR

ADRB3 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

ADRB3 - human gene knockout kit via CRISPR

ADRB3 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Adrb3 - mouse gene knockout kit via CRISPR

Adrb3 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Adrb3 - mouse gene knockout kit via CRISPR

Adrb3 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Adrb3 - mouse gene knockout kit via CRISPR

Adrb3 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Adrb3 - mouse gene knockout kit via CRISPR

Adrb3 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Adrb3 (GFP-tagged ORF) - Rat adrenergic, beta-3-, receptor (Adrb3), 200 uL, >10^7 TU/mL

Lenti ORF particles, Adrb3 (GFP-tagged ORF) - Rat adrenergic, beta-3-, receptor (Adrb3), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

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