Beta-adducin (ADD2) antibody

Principal name

Beta-adducin (ADD2) antibody

Alternative names for Beta-adducin (ADD2) antibody

ADDB, Adducin 2, Erythrocyte adducin subunit beta

SwissProt ID

P35612 (Human), Q05764 (Rat), Q9QYB8 (Mouse)

Gene ID

119 (ADD2), 11519 (Add2), 24171

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Rt (Rat), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), Immunoprecipitation (IP), Paraffin Sections (P)

Background of Beta-adducin (ADD2) antibody

Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Various adducin beta mRNAs, alternatively spliced at 3\'end and/or internally spliced and encoding different isoforms, have been described. The functions of all the different isoforms are not known.

General readings

Kato,N., (2008) Hum. Mol. Genet. 17 (4), 617-627

2 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Beta-adducin (ADD2) antibody

  Anti-ADD2 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm. Positive control: Human brain tissue. Recommended dilution: 1/15-50  The image on the left is immunohistochemistry of paraffin-embedded human brain tissue using ADD2 antibody at dilution 1/15, on the right is treated with the fusion protein. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €335.00
  OriGene Technologies, Inc.

Beta-adducin (ADD2) antibody

  Anti-ADD2 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm. Positive control: Human brain tissue. Recommended dilution: 1/15-50  The image on the left is immunohistochemistry of paraffin-embedded human brain tissue using ADD2 antibody at dilution 1/20, on the right is treated with the fusion protein. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €335.00
  OriGene Technologies, Inc.

2 Item(s)

per page
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