Beta-glucuronidase antibody

Principal name

Beta-glucuronidase antibody

Alternative names for Beta-glucuronidase antibody

GUSB, Beta-G1

SwissProt ID

O18835 (Canfa), O97524 (Felca), P05804 (Ecoli), P06760 (Rat), P08236 (Human), P12265 (Mouse), Q4FAT7 (Pig)

Gene ID

946149 (uidA), 2990 (GUSB), 24434 (Gusb)

Available reactivities

Bov (Bovine), Can (Canine), Chk (Chicken), Hu (Human), Ms (Mouse), Por (Porcine), Rt (Rat), Ze (Zebrafish), E. coli (Escherichia coli), Eq (Equine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Dot blot (Dot), Immunodiffusion (ID), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Radioimmunoassay (R), Flow Cytometry (F), ELISA (detection) (E(detection)), Frozen Sections (C)

Background of Beta-glucuronidase antibody

GUSB(Beta-Glucuronidase) is an enzyme that in humans is encoded by the GUSB gene. The GUSB gene encodes beta-glucuronidase, a lysosomal hydrolase involved in the stepwise degradation of glucuronic acid-containing glycosaminoglycans. It is a tetrameric glycoprotein composed of identical subunits. The GUSB gene is mutated in mucopolysaccharidosis type VII. Miller et al. (1990) reported that the GUSB gene is 21 kb long and contains 12 exons. The GUSB gene is mapped on 7q11.21. Beta-glucuronic acid acts naturally to cleave glucuronides from conjugated bilirubin to produce unconjugated bilirubin, which is then absorbed into the bloodstream.Kreamer et al. (2001) postulated that the beta-glucuronidase inhibitor L-aspartic acid can thus block enterohepatic circulation of bilirubin. Tomatsu et al. (2002) stated that more than 45 different mutations in the GUSB gene had been identified in human patients with MPS VII, approximately 90% of which were point mutations.

General readings

Tomatsu,S. Hum. Mutat. 30 (4), 511-519 (2009)
Romanowski,T. Med. Sci. Monit. 14 (7), BR147-BR152 (2008)
Gratz,M. Pharmacogenet. Genomics 15 (12), 875-881 (2005)

18 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Beta-glucuronidase antibody

  Rabbit polyclonal anti-GUSB antibody  
Western blot analysis of extracts from HeLa cells, using GUSB antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Beta-glucuronidase antibody

  Rabbit Polyclonal Anti-GUSB Antibody  
WB Suggested Anti-GUSB Antibody Titration: 2.5 ug/ml; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Eq, GP, Hu, Ms, Rb P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Beta-glucuronidase antibody

Beta-glucuronidase Mouse IgG1 105 Supernatant Hu C, E, WB
1 ml / €370.00
  Acris Antibodies GmbH

Beta-glucuronidase antibody

Beta-glucuronidase Rabbit IgG Azide Free E. coli Dot, E, ICC/IF, ID, IP, R, WB
10 mg / €240.00
  Acris Antibodies GmbH

Beta-glucuronidase antibody

Beta-glucuronidase Rabbit IgG Biotin E. coli Dot, E, ICC/IF, ID, IP, R, WB
1 ml / €350.00
  Acris Antibodies GmbH

Beta-glucuronidase (Center) antibody

Immunohistochemistry analysis in formalin-fixed and paraffin-embedded human colon carcinoma reacted with Beta-glucuronidase Antibody (Center) Cat.-No AP51986PU-N, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Aff - Purified Hu, Por F, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Beta-glucuronidase (C-term) antibody

Immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue reacted with Beta-glucuronidase Antibody (C-term) Cat.-No Cat.-No AP51987PU-N followed by peroxidase conjugation of the secondary antibody and DAB staining. Rabbit Ig Aff - Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Beta-glucuronidase antibody

Beta-glucuronidase Mouse IgM 1A6 Ig Fraction E
1 mg / €410.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

GUSB - human gene knockout kit via CRISPR

GUSB - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

GUSB - human gene knockout kit via CRISPR

GUSB - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

GUSB - human gene knockout kit via CRISPR

GUSB - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

GUSB - human gene knockout kit via CRISPR

GUSB - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Beta-glucuronidase

  Recombinant protein of human glucuronidase, beta (GUSB)  
Beta-glucuronidase Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

GUSB overexpression lysate

GUSB overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, GUSB (mGFP-tagged) - Human glucuronidase, beta (GUSB), 200 uL, >10^7 TU/mL

Lenti ORF particles, GUSB (mGFP-tagged) - Human glucuronidase, beta (GUSB), 200 uL, >10^7 TU/mL  
200 µl / €1,320.00
  OriGene Technologies, Inc.

Lenti ORF particles, GUSB (Myc-DDK tagged) - Human glucuronidase, beta (GUSB) , 200 uL, >10^7 TU/mL

Lenti ORF particles, GUSB (Myc-DDK tagged) - Human glucuronidase, beta (GUSB) , 200 uL, >10^7 TU/mL  
200 µl / €1,180.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Gusb (GFP-tagged ORF) - Rat glucuronidase, beta (Gusb), 200 uL, >10^7 TU/mL

Lenti ORF particles, Gusb (GFP-tagged ORF) - Rat glucuronidase, beta (Gusb), 200 uL, >10^7 TU/mL  
200 µl / €1,310.00
  OriGene Technologies, Inc.

Lenti ORF particles, Gusb (Myc-DDK-tagged ORF) - Rat glucuronidase, beta (Gusb), 200 uL, >10^7 TU/mL

Lenti ORF particles, Gusb (Myc-DDK-tagged ORF) - Rat glucuronidase, beta (Gusb), 200 uL, >10^7 TU/mL  
200 µl / €1,179.00
  OriGene Technologies, Inc.

18 Item(s)

per page
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