BICD2 antibody

Principal name

BICD2 antibody

Alternative names for BICD2 antibody

Bic-D2, KIAA0699, Protein bicaudal D homolog 2

SwissProt ID

Q8TD16 (Human), Q921C5 (Mouse)

Gene ID

23299 (BICD2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C)

Background of BICD2 antibody

BICD2 is the second human homolog discovered to the Drosophila Bicaudal-D protein that forms part of the cytoskeleton and mediates the correct sorting of mRs for oocyte- and axis-determining factors during oogenesis. Similar to the highly homologous protein BICD1, BICD2 can bind to dynein-dyctin complex, primarily through the dymitin subunit of dyctin. The C-terminus of BICD2 targets the protein to the Golgi complex while the N-termil domain of BICD2 co-immunoprecipitates with cytoplasmic dynein, suggesting BICD2 plays a role in the dynein-dyctin interaction on the surface of membranous organelles. Mice engineered to overexpress the BICD2 amino termil domain in neurons developed amyotrophic lateral sclerosis (ALS)-like features such as Golgi fragmentation, neurofilament swelling in proximal axons, etc., suggesting that impaired dynein/dyctin function may explain some of the pathological features observed in ALS patients. This BICD2 antibody will not cross-react with BICD1.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

BICD2 (C-term) antibody

Western blot analysis of BICD2 in A549 cell lysate with BICD2 antibody at (A) 1 and (B) 2 µg/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

BICD2 (Center) antibody

Western blot analysis of BICD2 in A549 cell lysate with BICD2 antibody at (A) 1 and (B) 2 µg/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

BICD2 (C-term) antibody

Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with BICD2 antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

BICD2 Control Peptide

BICD2
50 µg / €160.00
  Acris Antibodies GmbH

BICD2 Control Peptide

BICD2
50 µg / €160.00
  Acris Antibodies GmbH

BICD2 antibody

Western blot analysis of BICD2 in A-549 cell lysate with BICD2 polyclonal antibody ( Cat # PAB13387 ) at ( A ) 1 and ( B ) 2 µg/ml. Rabbit Hu, Ms, Rt WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

BICD2 antibody

Western blot analysis of BICD2 in A-549 cell lysate with BICD2 polyclonal antibody ( Cat # PAB13388 ) at ( A ) 1 and ( B ) 2 µg/ml. Rabbit Hu, Ms, Rt WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

BICD2 antibody

Immunohistochemistry-Paraffin: BICD2 Antibody [NBP1-81488] - Immunohistochemical staining of human esophagus shows strong cytoplasmic positivity in squamous epithelial cells. Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

BICD2 antibody

Immunohistochemistry-Paraffin: BICD2 Antibody [NBP1-81489] - Immunohistochemical staining of human adrenal gland shows strong cytoplasmic positivity in cortical cells. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

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