BIK antibody

Principal name

BIK antibody

Alternative names for BIK antibody

Bcl-2-interacting killer, NBK, BP4, BIP1, Apoptosis inducer NBK

SwissProt ID

Q13323 (Human)

Gene ID

638 (BIK)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Immunoprecipitation (IP)

Background of BIK antibody

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells and is caused by the activation of proteolytic enzymes termed caspases. Proteins that comprise the Bcl-2 family appear to control the activation of these enzymes. One such protein BIK was recently identified as an endoplasmic reticulum (ER)-residing pro-apoptotic member of the Bcl-2 homology domain-3 (BH3)-only group of the Bcl-2 family that stimulates mitochondrial release of cytochrome c following p53 induction of apoptosis. A significant fraction of BIK is found as an ER transmembrane protein, with most of the protein facing the cytosol. Restricting BIK to the ER membrane by replacing the transmembrane region with that of the ER-selective membrane anchor of cytochrome b(5) resulted in a decreased cytochrome c release from mitochondria and a corresponding drop in cell death. Recent evidence suggests that BIK cooperates with NOXA, another BH3-only protein, to somehow enhance the activation of Bax to stimulate the rapid release of cytochrome c from mitochondria.

2 Item(s)

per page

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, BIK (mGFP-tagged) - Human BCL2-interacting killer (apoptosis-inducing) (BIK), 200 uL, >10^7 TU/mL

Lenti ORF particles, BIK (mGFP-tagged) - Human BCL2-interacting killer (apoptosis-inducing) (BIK), 200 uL, >10^7 TU/mL  
200 µl / €907.00
  OriGene Technologies, Inc.

Lenti ORF particles, BIK (Myc-DDK tagged) - Human BCL2-interacting killer (apoptosis-inducing) (BIK) , 200 uL, >10^7 TU/mL

Lenti ORF particles, BIK (Myc-DDK tagged) - Human BCL2-interacting killer (apoptosis-inducing) (BIK) , 200 uL, >10^7 TU/mL  
200 µl / €804.00
  OriGene Technologies, Inc.

2 Item(s)

per page
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