BMF antibody

Principal name

BMF antibody

Alternative names for BMF antibody

Bcl-2-modifying factor

SwissProt ID

Q8K589 (Rat), Q91ZE9 (Mouse), Q96LC9 (Human)

Gene ID

90427 (BMF), 171543 (Bmf)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse, Rat

Available applications

Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Enzyme Immunoassay (E), Frozen Sections (C), Immunoprecipitation (IP), Flow Cytometry (F)

Background of BMF antibody

Apoptosis or programmed cell death is a physiological cellular process characterized by cell shrinkage, membrane blebbing, DNA fragmentation, and release of Cytochrome C from the mitochondria. It is utilized by the organism to get rid of unwanted cells, which is critical for normal development and homeostasis of an organism. Disregulation of normal apoptosis process have been implicated in a variety of diseases, including cancer, autoimmune diseases, viral infections, etc. Programmed cell death occurs through complex cascades of cell signaling in which Bcl-2 family members, among others, play an important role.The Bcl-2 family of proteins regulate apoptosis as well as execute death signals at the mitochondrion. Members of this family include both pro- and anti-apoptotic proteins that hare homology sequences called Bcl-2 Homology domains (BH1-4) which mediate dimmer formation. The BH3 proteins, such as BID, NOXA, PUMA, BIK, BIM and BAD are all pro-apoptotic and share sequence homology within the amphipathic alpha-helical BH3 region, which is required for their apoptotic function. They may trigger release of death-inducing molecules such as Cytochrome C, Smac, and endonuclease G. Anti-apoptotic family members, including Bcl-2 and Bcl-XL, play inhibitory roles. Bcl-2 family proteins may form homodimers or heterodimers between pro- and anti-apoptotic members, the ratios of which determine the cell fate.

General readings

Morales AA., et al. (2004). Leukemia. 18(1):41-7.
Chen L., et al. (2005). Mol Cell. 17(3):393-403.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

BMF antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-BMF mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA807459)(1:150) Mouse IgG2b OTI6F3 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

BMF antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-BMF mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA807461)(1:150) Mouse IgG1 OTI9B7 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

BMF (C-term) antibody

Western blot analysis of Bmf expression in HepG2 cell lysate with Bmf antibody at (A) 2.5 and (B) 5 ug/mL. Rabbit IgG Aff - Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

BMF (N-term) antibody

Western blot analysis of Bmf expression in human HepG2 (lane 1) and 293 (lane 2) cell lysates with Bmf antibody at 2 ug /ml. Rabbit IgG Aff - Purified Hu, Ms E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

BMF antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-BMF mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA807460) Mouse IgG1 OTI3E5 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

BMF antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY BMF (RC209733, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-BMF. Mouse IgG1 OTI5H2 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

BMF antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY BMF (RC209733, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-BMF. Mouse IgG2a OTI7B3 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

BMF antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY BMF (RC209733, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-BMF.(1:2000) Mouse IgG2a OTI4F4 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

BMF antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human thyroid tissue using anti-BMF mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA807685)(1:150) Mouse IgG1 OTI3H5 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

BMF antibody

Figure 1. Formalin-Fixed Paraffin-Embedded (FFPE) on Brain, cerebellum. Rabbit Aff - Purified Hu P, WB
50 µg / €470.00
  Acris Antibodies GmbH

BMF (BH3 Domain) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

BMF antibody

AP26342PU-N: Western blot analysis of BMF expression in Jurkat cell lysate (Lane 1 & 2), 3T3 cell lysate (Lane 3) and in Rat kidney tissue lysate (Lane 4). Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 mg / €370.00
  Acris Antibodies GmbH

BMF Control Peptide

BMF
50 µg / €160.00
  Acris Antibodies GmbH

BMF Control Peptide

BMF
50 µg / €160.00
  Acris Antibodies GmbH

BMF (N-term) antibody

Immunocytochemical staining of HeLa cells with Rabbit anti Bmf (SP1414P) Rabbit Purified Hu, Ms ICC/IF, WB
0.1 mg / €330.00
  Acris Antibodies GmbH

BMF antibody

BMF Rat IgG1 12E10 Purified Hu, Ms F, IP, WB
0.1 mg / €730.00
  Abnova Taiwan Corp.

BMF antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the BMF polyclonal antibody ( Cat # PAB2443 ) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma. Rabbit Hu E, P
0.4 ml / €390.00
  Abnova Taiwan Corp.

BMF antibody

Immunofluorescence of BMF in human kidney tissue with BMF polyclonal antibody ( Cat # PAB13104 ) at 10 µg/ml. Rabbit Hu C, ICC/IF, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

BMF antibody

Immunocytochemistry of BMF in HeLa cells with BMF polyclonal antibody ( Cat # PAB13105 ) at 10 µg/ml. Rabbit Hu, Ms ICC/IF, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

BMF antibody

BMF Mouse IgG RB0593-RB0594 Purified Hu, Ms E, IP, WB
0.1 mg / €530.00
  Novus Biologicals Inc.

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