BMP1 antibody

Principal name

BMP1 antibody

Alternative names for BMP1 antibody

Bone morphogenetic protein 1, PCOLC, BMP-1, Procollagen C-proteinase, Mammalian tolloid protein

SwissProt ID

P13497 (Human), P98063 (Mouse)

Gene ID

649 (BMP1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Por (Porcine)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Dot blot (Dot), ELISA (detection) (E(detection))

Background of BMP1 antibody

The transforming growth factor-beta (TGF-beta) super-family consists of a large number of growth and differentiation factors, such as TGF-betas, activins, inhibins, growth and differentiation factors (GDFs), and bone morphogenetic proteins (BMPs). These TGF beta ligands act through specific serine/threonine type I and Type II receptor kinases (1). These type I and II receptor kinases subsequently activate Smad proteins, which then propagate the signals into the nucleus to regulate target gene expression. Several BMP isotypes have been identified (BMP1 through MP16) have been recovered through molecular cloning. Recombinant protein products from several of these clones (BMP2-BMP16) are members of the TGF-beta super-family of regulatory ligands. There exist high degree of amino acid sequence homology between BMP5, BMP6, and BMP7, that constitute a subfamily within the BMPs. The signaling systems of BMP are highly conserved from flies to mammals and have been shown to be important in the development of multiple organs.
The bone morphogenetic proteins (BMP) are implicated in several inductive differentiation processes in vertebrate ontogeny and patterning of nervous system. Recently, these proteins have also emerged as candidates for regulating survival of mesencephalic dopaminergic and sympathetic neurons. It has been shown that several bone morphogenetic proteins are induced in 14 day developing embryonic rat dorsal root ganglia (2). BMPs exert survival promoting effects and positively modulate the effects of neurotrophins on sensory neurons (3). BMP2 is a 471amino acid protein with an apparent MW of 58 kDa. BMP2 transforms the human bone marrow-derived mesenchymal stem cells (MSCs) in to chondrocytic phenotype in high-density cultures (3). Recent studies suggest that BMP2 induced ectopic bone formation involves both endochondral and intramembranous ossification (4). Except for BMP-1, which is a metalloprotease, all other BMPs appears to be members of the TGF-beta regulatory molecules. BMP1 plays important roles in regulating the deposition of fibrous extracellular matrix in vertebrates, including provision of the procollagen C-proteinase activity that processes the major fibrillar collagens I-III. Biglycan, a small leucine-rich proteoglycan, is a nonfibrillar extracellular matrix component with functions that include the positive regulation of bone formation (5).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

BMP1 antibody

  Goat Polyclonal Anti-BMP1 (aa284-296) Antibody  
TA348935 (1 ug/ml) staining of Human Heart (A) and Kidney (B) lysates (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Purified Bov, Can, Hu, Ms, Por, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

BMP1 antibody

  BMP1 mouse monoclonal antibody, clone OTI3E9 (formerly 3E9)  
Anti-BMP1 mouse monoclonal antibody (TA505813) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY BMP1(RC212538). Mouse IgG1 OTI3E9 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

BMP1 (972-986) antibody

Figure 1. Staining BMP1 in Liver by Immunohistochemistry using Formalin-Fixed Paraffin-Embedded (FFPE) tissue. Rabbit Purified Hu E, P
50 µg / €470.00
  Acris Antibodies GmbH

BMP1 (121-730) antibody

BMP1 Goat Aff - Purified Hu E, ICC/IF, IP, WB
0.1 mg / €450.00
  Neuromics Antibodies

CRISPR

Catalog No. Species Donor Vector  

BMP1 - human gene knockout kit via CRISPR

BMP1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

BMP1 - human gene knockout kit via CRISPR

BMP1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

BMP1 - human gene knockout kit via CRISPR

BMP1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

BMP1 - human gene knockout kit via CRISPR

BMP1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

BMP1 overexpression lysate

BMP1 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

BMP1 overexpression lysate

BMP1 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

BMP1 overexpression lysate

BMP1 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, BMP1 (mGFP-tagged) - Human bone morphogenetic protein 1 (BMP1), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, BMP1 (mGFP-tagged) - Human bone morphogenetic protein 1 (BMP1), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, BMP1 (mGFP-tagged) - Human bone morphogenetic protein 1 (BMP1), transcript variant BMP1-2, 200 uL, >10^7 TU/mL

Lenti ORF particles, BMP1 (mGFP-tagged) - Human bone morphogenetic protein 1 (BMP1), transcript variant BMP1-2, 200 uL, >10^7 TU/mL  
200 µl / €1,950.00
  OriGene Technologies, Inc.

Lenti ORF particles, BMP1 (Myc-DDK tagged) - Human bone morphogenetic protein 1 (BMP1), transcript variant 3 , 200 uL, >10^7 TU/mL

Lenti ORF particles, BMP1 (Myc-DDK tagged) - Human bone morphogenetic protein 1 (BMP1), transcript variant 3 , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Lenti ORF particles, BMP1 (Myc-DDK tagged) - Human bone morphogenetic protein 1 (BMP1), transcript variant BMP1-2 , 200 uL, >10^7 TU/mL

Lenti ORF particles, BMP1 (Myc-DDK tagged) - Human bone morphogenetic protein 1 (BMP1), transcript variant BMP1-2 , 200 uL, >10^7 TU/mL  
200 µl / €1,760.00
  OriGene Technologies, Inc.

15 Item(s)

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