BMP14 / GDF5 antibody

Principal name

BMP14 / GDF5 antibody

Alternative names for BMP14 / GDF5 antibody

Bone Morphogenetic Protein 14, GDF-5, CDMP1, Radotermin, Growth/differentiation factor 5, Cartilage-derived morphogenetic protein 1

SwissProt ID

P43026 (Human), P43027 (Mouse)

Gene ID

8200 (GDF5), 1118200 (Q97HJ4), 14563

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Rabbit, Mouse, Chicken

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Frozen Sections (C), Flow Cytometry (F), Western blot / Immunoblot (WB)

Background of BMP14 / GDF5 antibody

Bone Morphogenetic Proteins (BMPs) are members of the TGF beta superfamily of cytokines that affect bone and cartilage formation. Similar to other TGF beta family proteins, BMPs are highly conserved across animal species. Mature BMPs are 30-38 kDa proteins that assume a TGF beta like cysteine knot configuration. Unlike TGF beta, BMPs do not form latent complexes with their propeptide counterparts. Most BMPs are homodimers, but bioactive natural heterodimers have been reported. Recently it was found that lovostatin, widely used for lowering cholesterol, also increases bone formation by turning on a gene (bmp2) that promotes local bone formation. BMPs create an environment conducive for bone marrow development by stimulating the production of specific bone matrix proteins and altering stromal cell and osteoclast proliferation. In addition to stimulating ectopic bone and cartilage development, BMPs may be an important factor in the development of the viscera, with roles in cell proliferation, apoptosis, differentiation, and morphogenesis. BMPs also appear to be responsible for normal dorsal/ventral patterning. BMPs are found in tissues that induce bone or cartilage growth, such as demineralized bone and urinary epithelium. Cellular responses to BMP5 are mediated by the formation of hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors which play significant roles in BMP binding and signaling. One BMP type II receptor and two BMP type I receptors have been identified.

General readings

Posthumus, M., et al. Rheumatology (Oxford) 49(11):2090-2097(2010)
Rouault, K., et al. Osteoarthr. Cartil. 18(9):1144-1149(2010)
Zintzaras, E., et al. Am. J. Epidemiol. 171(8):851-858(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Zhao, J., et al. BMC Med. Genet. 11, 96 (2010)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

BMP14 / GDF5 antibody

WB Suggested Anti-GDF5 Antibody; Titration: 1.0 ug/ml; Positive Control: Placenta Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

BMP14 / GDF5 (28-41) antibody

Figure 1. Staining GDF5 in Skin by Immunohistochemistry using Formalin-Fixed Paraffin-Embedded (FFPE) tissue. Rabbit Purified Hu E, P
50 µg / €470.00
  Acris Antibodies GmbH

BMP14 / GDF5 (N-term) antibody

Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with GDF5 antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu WB

Regular Price: 0.4 ml / €370.00

Special Price: 0.4 ml / €231.00

  Acris Antibodies GmbH

BMP14 / GDF5 (C-term) antibody

Immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue reacted with BMP14 / GDF5 Antibody (C-term) Cat.-No AP51811PU-N followed by peroxidase conjugation of the secondary antibody and DAB staining. Rabbit Ig Aff - Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

BMP14 / GDF5 antibody

BMP14 / GDF5 Mouse Clone 90509 Purified Hu, Ms C, F, P
0.5 mg / €410.00
  Neuromics Antibodies

BMP14 / GDF5 antibody

BMP14 / GDF5 Rabbit IgG Aff - Purified Hu WB
0.1 mg / €440.00
  Novus Biologicals Inc.

BMP14 / GDF5 antibody

Immunohistochemistry-Paraffin: GDF5 Antibody [NBP1-88575] - Immunohistochemical staining of human stomach shows strong cytoplasmic positivity in glandular cells. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

BMP14 / GDF5

BMP14 / GDF5 Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
E. coli

Regular Price: 50 µg / €199.00

Special Price: 50 µg / €139.00

  OriGene Technologies, Inc.

BMP14 / GDF5

BMP14 / GDF5 Mouse > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
E. coli

Regular Price: 50 µg / €199.00

Special Price: 50 µg / €139.00

  OriGene Technologies, Inc.

BMP14 / GDF5 (382-501, His-tag)

BMP14 / GDF5 Human Purified > 95 % by SDS - PAGE E. coli
0.5 mg / €750.00
  Acris Antibodies GmbH

BMP14 / GDF5 (382-501, His-tag)

BMP14 / GDF5 Human Purified > 95 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

BMP14 / GDF5

BMP14 / GDF5 Mouse Purified > 98 % by SDS-PAGE gel and HPLC analyses E. coli
50 µg / €230.00
  Acris Antibodies GmbH

BMP14 / GDF5

BMP14 / GDF5 Mouse Purified > 98 % by SDS-PAGE gel and HPLC analyses E. coli
10 µg / €140.00
  Acris Antibodies GmbH

BMP14 / GDF5 (376-495, His-tag)

BMP14 / GDF5 Human Purified > 90 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

BMP14 / GDF5 (376-495, His-tag)

BMP14 / GDF5 Human Purified > 90 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

BMP14 / GDF5

BMP14 / GDF5 Human
10 µg / €380.00
  Abnova Taiwan Corp.

BMP14 / GDF5

BMP14 / GDF5 Human
25 µg / €510.00
  Abnova Taiwan Corp.

BMP14 / GDF5

BMP14 / GDF5 Human
0.1 mg / €380.00
  Abnova Taiwan Corp.

BMP14 / GDF5

BMP14 / GDF5 Human
10 µg / €290.00
  Abnova Taiwan Corp.

BMP14 / GDF5

BMP14 / GDF5 Human
50 µg / €330.00
  Abnova Taiwan Corp.

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