BMP2 / BMP2A antibody

Principal name

BMP2 / BMP2A antibody

Alternative names for BMP2 / BMP2A antibody

Bone morphogenetic protein 2, BMP-2, BMP-2A

SwissProt ID

P12643 (Human), P21274 (Mouse), P49001 (Rat), Q90751 (Chick)

Gene ID

650 (BMP2), 29373 (Bmp2), 4331650 (Os03g0152400), 12156

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse), Eq (Equine), Chk (Chicken), Bov (Bovine), Por (Porcine), Rb (Rabbit), Sh (Sheep), Ze (Zebrafish)

Available hosts

Goat, Rabbit, Mouse

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Dot blot (Dot), Functional assay (FN), Immunoprecipitation (IP), Paraffin Sections (P), ELISA (detection) (E(detection))

Background of BMP2 / BMP2A antibody

The transforming growth factor-beta (TGF-beta) super-family consists of a large number of growth and differentiation factors, such as TGF-betas, activins, inhibins, growth and differentiation factors (GDFs), and bone morphogenetic proteins (BMPs). These TGF beta ligands act through specific serine/threonine type I and Type II receptor kinases (1). These type I and II receptor kinases subsequently activate Smad proteins, which then propagate the signals into the nucleus to regulate target gene expression. Several BMP isotypes have been identified (BMP1 through MP16) have been recovered through molecular cloning. Recombinant protein products from several of these clones (BMP2-BMP16) are members of the TGF-beta super-family of regulatory ligands. There exist high degree of amino acid sequence homology between BMP5, BMP6, and BMP7, that constitute a subfamily within the BMPs. The signaling systems of BMP are highly conserved from flies to mammals and have been shown to be important in the development of multiple organs.
The bone morphogenetic proteins (BMP) are implicated in several inductive differentiation processes in vertebrate ontogeny and patterning of nervous system. Recently, these proteins have also emerged as candidates for regulating survival of mesencephalic dopaminergic and sympathetic neurons. It has been shown that several bone morphogenetic proteins are induced in 14 day developing embryonic rat dorsal root ganglia (2). BMPs exert survival promoting effects and positively modulate the effects of neurotrophins on sensory neurons (3). BMP2 is a 471amino acid protein with an apparent MW of 58 kDa. BMP2 transforms the human bone marrow-derived mesenchymal stem cells (MSCs) in to chondrocytic phenotype in high-density cultures (3). Recent studies suggest that BMP2 induced ectopic bone formation involves both endochondral and intramembranous ossification (4). Except for BMP-1, which is a metalloprotease, all other BMPs appears to be members of the TGF-beta regulatory molecules. BMP1 plays important roles in regulating the deposition of fibrous extracellular matrix in vertebrates, including provision of the procollagen C-proteinase activity that processes the major fibrillar collagens I-III. Biglycan, a small leucine-rich proteoglycan, is a nonfibrillar extracellular matrix component with functions that include the positive regulation of bone formation (5).

General readings

General / background references:Peng C The TGF-beta superfamily and its roles in the human ovary and placenta. J Obstet Gynaecol Can 25:834-44 (2003). PubMed PMID: 14532952
Schmitt B et al. BMP2 initiates chondrogenic lineage development of adult human mesenchymal stem cells in high-density culture. Differentiation 71:567-77 (2003). PubMed PMID: 14686954
Stoeger T et al. In situ gene expression analysis during BMP2-induced ectopic bone formation in mice shows simultaneous endochondral and intramembranous ossification. Growth Factors 20:197-210 (2002). PubMed PMID: 12708796
Scott IC et al. Bone morphogenetic protein-1 processes probiglycan. J Biol Chem 275:30504-11 (2000). PubMed PMID: 10896944
Farkas LM et al. Characterization of bone morphogenetic protein family members as neurotrophic factors for cultured sensory neurons. Neuroscience 92:227-35 (1999). PubMed PMID: 10392845

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

BMP2 / BMP2A antibody

This antibody stained formalin-fixed, paraffin-embedded sections of human colon/rectum adenocarcinoma.  The recommended concentration is 0.25 ug/ml with an overnight incubation at 4C.  An HRP-labeled polymer detection system was used with a DAB chromogen.  Heat induced antigen retrieval with a pH 6.0 sodium citrate buffer is recommended.  Optimal concentrations and conditions may vary.    *Additional Immunostaining data available. Please contact Tech Support for information. Rabbit IgG Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

BMP2 / BMP2A antibody

Western Blot: BMP2 Antibody [TA336740] - Extracts from HUVEC cells. Rabbit Purified Hu, Ms, Rt C, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

BMP2 / BMP2A antibody

The lysate of HeLa (30ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human BMP2 antibody(1:500-1:2000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG2b AT15B3 Purified Hu E, WB
0.1 ml / €310.00
  Acris Antibodies GmbH

BMP2 / BMP2A antibody

The lysate of HeLa (30ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human BMP2 antibody(1:500-1:2000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG2b AT15B3 Purified Hu E, WB
50 µl / €220.00
  Acris Antibodies GmbH

BMP2 / BMP2A (86-102) antibody

Figure 1. Heart: Formalin-Fixed Paraffin-Embedded (FFPE) using anti BMP2A/BMP2 antibody. Rabbit Purified Hu E, P
50 µg / €470.00
  Acris Antibodies GmbH

BMP2 / BMP2A control peptide

BMP2 / BMP2A Ms
0.25 mg / €250.00
  Acris Antibodies GmbH

BMP2 / BMP2A (45-60) antibody

BMP2 / BMP2A Rabbit Aff - Purified Hu, Ms, Rt Dot, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

BMP2 / BMP2A (aa 261-290) antibody

Immunohistochemistry analysisof BMP-2 Antibody (Cat.-No. AP20597PU-N) in paraffin-embedded human heart tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

BMP2 / BMP2A (+ BMP4) antibody

Western analysis of Human BMP-2 with a polyclonal antibody directed against Human BMP-2 derived from E. coli. Rabbit Purified Hu E, IP, WB
0.2 mg / €290.00
  Acris Antibodies GmbH

BMP2 / BMP2A (+ BMP4) antibody

Western analysis of Human BMP-2 with a polyclonal antibody directed against Human BMP-2 derived from E. coli. Rabbit Purified Hu E, IP, WB
0.1 mg / €230.00
  Acris Antibodies GmbH

BMP2 / BMP2A antibody

Direct ELISA using BMP2 Antibody Cat.-No PP1219B Rabbit Biotin Hu E, WB
25 µg / €230.00
  Acris Antibodies GmbH

BMP2 / BMP2A antibody

Direct ELISA using BMP2 Antibody Cat.-No PP1219B Rabbit Biotin Hu E, WB
50 µg / €340.00
  Acris Antibodies GmbH

BMP2 / BMP2A antibody

PP1219P BMP2 Antibody Staining of formalin-fixed, paraffin-embedded sections of Human colon/rectum adenocarcinoma Rabbit Aff - Purified Hu E, FN, WB
50 µg / €230.00
  Acris Antibodies GmbH

BMP2 / BMP2A antibody

PP1219P BMP2 Antibody Staining of formalin-fixed, paraffin-embedded sections of Human colon/rectum adenocarcinoma Rabbit Aff - Purified Hu E, FN, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

BMP2 / BMP2A antibody

BMP2 / BMP2A Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

BMP2 / BMP2A antibody

Western Blot analysis of BMP2 expression in transfected 293T cell line (H00000650-T01) by BMP2 MaxPab polyclonal antibody.

Lane 1: BMP2 transfected lysate(43.56 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

BMP2 / BMP2A antibody

BMP2 / BMP2A Mouse Hu WB
50 µg / €370.00
  Abnova Taiwan Corp.

BMP2 / BMP2A antibody

BMP2 MaxPab rabbit polyclonal antibody. Western Blot analysis of BMP2 expression in human liver. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

BMP2 / BMP2A antibody

BMP2 / BMP2A Mouse IgG2a 1A11 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

BMP2 / BMP2A antibody

Proximity Ligation Analysis (PLA) of protein-protein interactions between TGFB2 and BMP2 HeLa cells were stained with anti-TGFB2 rabbit purified polyclonal 1:1200 and anti-BMP2 mouse monoclonal antibody 1:50. Signals were detected by Duolink® 30 Detection Kit 613(red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex. Mouse IgG2a 4B12 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

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