BMP4 antibody

Principal name

BMP4 antibody

Alternative names for BMP4 antibody

BMP2B, BMP-2B, BMP-4, DVR4, Bone morphogenetic protein 4

SwissProt ID

P12644 (Human), P21275 (Mouse), Q06826 (Rat), Q2KJH1 (Bovin)

Gene ID

652 (BMP4), 12159 (Bmp4), 496529 (ywhab)

Available reactivities

Hu (Human), Bov (Bovine), Chk (Chicken), Frog, Ms (Mouse), Por (Porcine), Rt (Rat), Ze (Zebrafish), Rb (Rabbit), Bt (Bat), Can (Canine), Eq (Equine), Fi (Fish), Gt (Goat), Hst (Hamster), Mky (Monkey), Op (Opossum), Sh (Sheep), Xen (Xenopus), Bear

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Functional assay (FN), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Dot blot (Dot), Flow Cytometry (F), Immunoprecipitation (IP)

Background of BMP4 antibody

The Bone morphogenetic proteins (BMPs) are members of the TGF-beta superfamily of cytokines that are involved in development, differentiation, and disease. T he transforming growth factor-beta (TGF-beta) super-family consists of a large number of growth and differentiation factors, such as TGF-betas, activins, inhibins, growth and differentiation factors (GDFs), and bone morphogenetic proteins (BMPs). These TGF beta ligands act through specific serine/threonine type I and Type II receptor kinases (1). These type I and II receptor kinases subsequently activate Smad proteins, which then propagate the signals into the nucleus to regulate target gene expression. Several BMP isotypes have been identified (BMP1 through BMP16) have been recovered through molecular cloning. Recombinant protein products from several of these clones (BMP2-BMP16) are members of the TGF-beta super-family of regulatory ligands. There exist high degree of amino acid sequence homology between BMP5, BMP6, and BMP7, that constitute a subfamily within the BMPs. The signaling systems of BMP are highly conserved from flies to mammals and have been shown to be important in the development of multiple organs.
The formation of skeleton requires a highly regulated inductive signals with antagonist negative feed back system. Inappropriate or excessive expression of BMPs (bone morphogenetic proteins) or their antagonists (Noggin, ectodin) results in genetic disorders affecting the skeleton, such as fibrodysplasia ossificans progressiva. BMP signaling mediated through binding to its receptors is a critical step in the induction of abnormal ossification. BMP-4 expression has been shown in the developmental bone formation in the alveolar bone of rat embryo by immunohistochemistry (2). The bone morphogenetic proteins (BMP) are implicated in several inductive differentiation processes in vertebrate ontogeny and patterning of nervous system. BMP4 and its antagonist Noggin play important role in the CNS development, the expression of BMP4 in rat hippocampus increase gradually and reached its highest levels during weaning and then decline slightly there after (3). BMP4 is also required in normal development of mouse inner ear (3).

General readings

Moon BS., et al. (2009) Exp Mol Med. 41(2):116-25.
Li BC., et al. (2009) J Trauma. 66(2):450-6.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

BMP4 antibody

BMP4 Mouse IgG1 UMAB42 Purified Hu
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

BMP4 antibody

BMP4 Mouse IgG1 UMAB42 Purified Hu
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

BMP4 antibody

BMP4 Mouse IgG1 OTI6B7 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

BMP4 antibody

BMP4 Mouse IgG1 PA354-16.1.1 Purified Hu E, F, P, WB
0.1 mg / €360.00
  Protein Alternatives

BMP4 antibody

Predicted band size: 47 kDa . Positive control: Human lymphoma tissue lysate. Recommended dilution: 1/200-1000. (Gel: 10%+12%SDS-PAGE Lysate: 40 ug Primary antibody: 1/350 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 10 seconds) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

BMP4 antibody

Predicted band size: 47 kDa . Positive control: Mouse intestinumm tenue tissue lysate. Recommended dilution: 1/200-1000. (Gel: 10%+12%SDS-PAGE Lysate: 50 ug Primary antibody: 1/450 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 20 minutes) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

BMP4 antibody

Immunofluorescence staining of HepG2 cells using BMP4 antibody Cat.-No AM01363PU-N. The primary antibody was incubated at 3.0 µg/ml overnight at 4˚C followed by a fluorescent labeled secondary antibody. Information and photo are courtesy of the Cell Profiling group, SciLifeLab Stockholm. Mouse IgG2b Azide Free Hu E, FN, ICC/IF, WB
0.5 mg / €220.00
  Acris Antibodies GmbH

BMP4 antibody

Western blot analysis using BMP4 mouse mAb against BMP4-hIgGFc transfected HEK293 cell lysate. Mouse IgG1 10F4B4 Ascites Hu E, WB
0.1 ml / €400.00
  Acris Antibodies GmbH

BMP4 (20-34) antibody

Figure 1. Staining BMP4 in Lung, Respiratory Epithelium by Immunohistochemistry using Formalin-Fixed Paraffin-Embedded (FFPE) tissue. Rabbit Purified Hu E, P
50 µg / €470.00
  Acris Antibodies GmbH

BMP4 control peptide

BMP4
0.25 mg / €250.00
  Acris Antibodies GmbH

BMP4 (184-197) antibody

BMP4 Rabbit Aff - Purified Hu, Ms, Rt Dot, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

BMP4 antibody

Human Colon (formalin-fixed, paraffin-embedded) stained with BMP4 antibody AP22623PU-N at 1/100 followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit IgG Purified Bear, Bov, Bt, Can, Chk, Elephant, Eq, Fi, Gt, Hst, Hu, Mky, Ms, Op, Por, Prim, Rb, Rt, Sh, Shrew, Xen P, WB
50 µl / €470.00
  Acris Antibodies GmbH

BMP4 antibody

Formalin-Fixed, Paraffin-Embedded Human Kidney stained with BMP4 antibody Cat.-No AP22650PU-N at 5 µg/ml after heat-induced antigen retrieval. Rabbit Aff - Purified Chk, Hu, Ms, Rb, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

BMP4 antibody

BMP4 Mouse IgG2b 3H2 Hu, Ms P, WB
1 ml / €1,080.00
  Abnova Taiwan Corp.

BMP4 antibody

BMP4 Rabbit Hu WB
0.1 ml / €390.00
  Abnova Taiwan Corp.

BMP4 antibody

Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with BMP4 polyclonal antibody ( Cat # PAB3673 ) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. Rabbit Hu E, P
0.1 mg / €390.00
  Abnova Taiwan Corp.

BMP4 antibody

Western blot analysis of BMP4 polyclonal antibody using recombinant human BMP4. Rabbit Hu WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

BMP4 antibody

BMP4 Rabbit Chk, Hu, Ms, Rb, Rt WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

BMP4 antibody

BMP4 Mouse IgG2b 3H2 Supernatant Hu P, WB
0.1 ml / €280.00
  Neuromics Antibodies

BMP4 (20-34) antibody

BMP4 staining of Human Lung Tissue, respiratory epithelium: Formalin-Fixed Paraffin-Embedded (FFPE). Rabbit IgG Aff - Purified Bov, Chk, Frog, Hu, Ms, Por, Rt, Ze P
50 µg / €460.00
  Neuromics Antibodies

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