BMP5 antibody

Principal name

BMP5 antibody

Alternative names for BMP5 antibody

Bone morphogenetic protein 5, BMP-5

SwissProt ID

P22003 (Human), P49003 (Mouse)

Gene ID

653 (BMP5)

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse), Chk (Chicken), Por (Porcine), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Rb (Rabbit), Ze (Zebrafish)

Available hosts

Goat, Mouse, Rabbit

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection))

Background of BMP5 antibody

Bone Morphogenetic Proteins (BMPs) are members of the TGF beta superfamily of cytokines that affect bone and cartilage formation. Similar to other TGF beta family proteins, BMPs are highly conserved across animal species. Mature BMPs are 30-38 kDa proteins that assume a TGF beta like cysteine knot configuration. Unlike TGF beta, BMPs do not form latent complexes with their propeptide counterparts. Most BMPs are homodimers, but bioactive natural heterodimers have been reported. Recently it was found that lovostatin, widely used for lowering cholesterol, also increases bone formation by turning on a gene (bmp2) that promotes local bone formation. BMPs create an environment conducive for bone marrow development by stimulating the production of specific bone matrix proteins and altering stromal cell and osteoclast proliferation. In addition to stimulating ectopic bone and cartilage development, BMPs may be an important factor in the development of the viscera, with roles in cell proliferation, apoptosis, differentiation, and morphogenesis. BMPs also appear to be responsible for normal dorsal/ventral patterning. BMPs are found in tissues that induce bone or cartilage growth, such as demineralized bone and urinary epithelium. Cellular responses to BMP5 are mediated by the formation of hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors which play significant roles in BMP binding and signaling. One BMP type II receptor and two BMP type I receptors have been identified.
BMP5 induces cartilage and bone formation and is expressed in lung and liver tissue.

General readings

Mailhot G., et al. (2008). J Cell Physiol. 214(1):56-64.
Matus DQ., et al. (2006). Proc Natl Acad Sci U S A. 103(30):11195-200.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

BMP5 (31-46) antibody

Anti-BMP5 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. Rabbit Purified Hu E, P
50 µg / €345.00
  OriGene Technologies, Inc.

BMP5 antibody

Western blot analysis using recombinant human BMP-5. Lane 1: 50 ng, Lane2: 100 ng, Lane 3: 200 ng, Lane 4: 500 ng. Rabbit Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

BMP5 antibody

Western blot analysis of BMP-5 expression using 3T3 cell lysate. Rabbit Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

BMP5 antibody

Host: Rabbit; Target Name: Bmp5; Sample Tissue: Rat Brain lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

BMP5 (N-term) antibody

Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

BMP5 antibody

Immunohistochemistry analysis of BMP-5 Antibody (Cat.-No AP20581PU-N) in paraffin-embedded human heart tissue. Rabbit Aff - Purified Hu, Ms P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

BMP5 antibody

BMP5 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

BMP5 antibody

Western Blot analysis of BMP5 expression in transfected 293T cell line (H00000653-T01) by BMP5 MaxPab polyclonal antibody.

Lane 1: BMP5 transfected lysate(49.94 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

BMP5 antibody

BMP5 MaxPab rabbit polyclonal antibody. Western Blot analysis of BMP5 expression in human liver. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

BMP5 antibody

Detection limit for recombinant GST tagged BMP5 is approximately 0.1ng/ml as a capture antibody. Mouse IgG2a 2F12 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

BMP5 antibody

BMP5 Mouse IgG2b 1C1 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

BMP5 antibody

BMP5 Mouse IgG2b 3G11 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

BMP5 antibody

BMP5 Mouse IgG2a 2A5 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

BMP5 antibody

BMP5 Mouse IgG2a 3D10 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

BMP5 antibody

BMP5 Mouse IgG2b 3H6 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

BMP5 antibody

Detection limit for recombinant GST tagged BMP5 is approximately 0.3ng/ml as a capture antibody. Mouse IgG2a 4B3 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

BMP5 antibody

Detection limit for recombinant GST tagged BMP5 is approximately 0.3ng/ml as a capture antibody. Mouse IgG2a 4A9 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

BMP5 antibody

Detection limit for recombinant GST tagged BMP5 is approximately 0.3ng/ml as a capture antibody. Mouse IgG2a 4D10 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

BMP5 antibody

BMP5 Mouse IgG2b 4A3 Hu E
0.2 ml / €370.00
  Abnova Taiwan Corp.

BMP5 antibody

BMP5 Mouse IgG2a 1G6 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

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