BMP7 antibody

Principal name

BMP7 antibody

Alternative names for BMP7 antibody

BMP-7, Bone morphogenetic protein 7, OP1, Osteogenic protein 1

SwissProt ID

G3V6W8, P18075 (Human), P23359 (Mouse), P30886, P34819 (Canfa)

Gene ID

655 (BMP7), 85272 (Bmp7)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Chk (Chicken), Por (Porcine), Rb (Rabbit), Ze (Zebrafish), Mky (Monkey)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Functional assay (FN), ELISA (detection) (E(detection)), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of BMP7 antibody

Bone morphogenetic protein 7 (BMP-7), also known as osteogenic protein 1 (OP1), is a widely expressed TGFβ superfamily member with important functions during embryogenesis, in the adult, and in disease (1,2). Human BMP-7 is synthesized with a 29 amino acid (aa) signal sequence, a 263 aa propeptide, and a 139 aa growth factor domain (3). The growth factor domain of human BMP-7 shares 98% aa sequence identity with mouse and rat BMP-7. The BMP-7 propeptide is cleaved intracellularly but often remains associated with the mature C-terminus. Based on in vivo and in vitro studies, BMP-7 has the potential to be secreted as a disulfide-linked mature homodimer, or particularly as a heteromeric complex that consists of two propeptides noncovalently associated with a mature disulfide linked homodimer (5,6). The presence of the propeptides in BMP-7 appears to stabilize the molecule and provide a docking mechanism for extracellular storage on molecules such as fibrillin1 and 2 (5,6). The propeptides themselves do not impart latency to the complex. BMP-7 binding to type II receptors rapidly displaces the prodomain: mature molecule interaction and has no effect on activity. But it is suggested that immobilized BMP-7 (via prodomain:fibrillin) is inactive, allowing for possible long term storage of the molecule (6). BMP-7 interacts with the type 2 receptors Activin RIIA, Activin RIIB, and BMPRII and the type 1 receptors Activin RIA, BMPRIA, and BMPRIB (2,6). BMP-7 may also be processed into a disulfide-linked heterodimer with either BMP-2 or BMP-4. Such complexes may show increased potency and range of activity compared to BMP7 homodimers (7-9). BMP-7 plays a role in a variety of organ systems. It promotes new bone formation and nephron development (10,11), inhibits the branching of prostate epithelium (12), and antagonizes epithelial mesenchymal transition (EMT) (13-15). In pathological conditions, BMP-7 inhibits tumor growth and metastasis (14), ameliorates fibrotic damage in nephritis (13), and promotes neuro regeneration following brain ischemia (16).

General readings

Gregory KE., et al. (2005) J. Biol, Chem. 280, 27970-27980.
Sampath TK., et al. (1990) J. Biol. Chem. 265, 13198-13205.
Godin RE., et al. (1998) Development. 125, 3473-3482.
Groppe J., et al. (2002) Nature. 420, 636-642.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

BMP7 antibody

  Rabbit anti-BMP7 Polyclonal Antibody  
Western blot analysis of Prostate cell and Kidney cell lysate using BMP7 antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

BMP7 antibody

  Anti-Human BMP-7 Rabbit Polyclonal Antibody  
IHC of human breast invasive ductal carcinoma.  The recommended concentration is 0.25 ug/ml with an overnight incubation at 4C.  An HRP-labeled polymer detection system was used with a DAB chromogen.  Heat induced antigen retrieval with a pH 6.0 sodium citrate buffer is recommended. Optimal concentrations and conditions may vary. Rabbit IgG Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

BMP7 antibody

  Rabbit Polyclonal Anti-Bmp7 Antibody  
WB Suggested Anti-Bmp7 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: Rat Lung Rabbit IgG Purified Hu, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

BMP7 antibody

  Rabbit Polyclonal Anti-BMP7 Antibody  
WB Suggested Anti-BMP7 Antibody Titration: 1.25ug/ml; ELISA Titer: 1:1562500; Positive Control: Transfected 293T Rabbit IgG Purified Hu P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

BMP7 antibody

BMP7 Mouse IgG1 Azide Free Hu E
0.5 mg / €220.00
  Acris Antibodies GmbH

BMP7 antibody

BMP7 Rabbit Biotin Hu E, WB
50 µg / €340.00
  Acris Antibodies GmbH

BMP7 antibody

BMP7 Rabbit Biotin Hu E, WB
25 µg / €230.00
  Acris Antibodies GmbH

BMP7 antibody

BMP7 Rabbit Purified Hu E, FN, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

BMP7 antibody

BMP7 Rabbit Purified Hu E, FN, WB
50 µg / €230.00
  Acris Antibodies GmbH

BMP7 (N-term) antibody

Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu ICC/IF, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

BMP7 antibody

Immunohistochemistry (IHC) analyzes of BMP-7 antibody (Cat.-No.: AP20768PU-N) in paraffin-embedded human tonsil tissue. Rabbit Aff - Purified Hu, Ms, Rt P
0.1 mg / €350.00
  Acris Antibodies GmbH

BMP7 antibody

Western Analysis of anti-Human BMP7 antibody. Sample was loaded in 15% SDS-polyacrylamide gel under reducing conditions. 
Left panel: Molecular Standard. 
Right panel: rh BMP-7 derived from E. coli. Rabbit IgG Purified Hu WB
0.2 mg / €370.00
  Acris Antibodies GmbH

BMP7 antibody

Western Analysis of anti-Human BMP7 antibody. Sample was loaded in 15% SDS-polyacrylamide gel under reducing conditions. 
Left panel: Molecular Standard. 
Right panel: rh BMP-7 derived from E. coli. Rabbit IgG Purified Hu WB
0.1 mg / €270.00
  Acris Antibodies GmbH

BMP7 (N-term) antibody

BMP7 Rabbit Purified Hu E
1 ml / €490.00
  Acris Antibodies GmbH

BMP7 antibody

Western blot analysis:  The extracts of mouse kidney (MK) and rat heart (RH) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human BMP7 antibody (1:1,000). Protein was visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG1 4E7 Purified Hu, Ms, Rt E, WB
0.1 ml / €310.00
  Acris Antibodies GmbH

BMP7 antibody

Western blot analysis:  The extracts of mouse kidney (MK) and rat heart (RH) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human BMP7 antibody (1:1,000). Protein was visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG1 4E7 Purified Hu, Ms, Rt E, WB
50 µl / €230.00
  Acris Antibodies GmbH

BMP7 antibody

BMP7 in paraffin-embedded human prostate cancer tissue. HRP-DAB reagents (brown color) were used for the detection. Tissue sections were counterstained using hematoxylin (blue).. Mouse IgG1 Purified Hu, Rt P
0.5 mg / €410.00
  Neuromics Antibodies

CRISPR

Catalog No. Species Donor Vector  

BMP7 - human gene knockout kit via CRISPR

BMP7 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

BMP7 - human gene knockout kit via CRISPR

BMP7 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

BMP7 - human gene knockout kit via CRISPR

BMP7 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

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