BMP7 antibody

Principal name

BMP7 antibody

Alternative names for BMP7 antibody

BMP-7, Bone morphogenetic protein 7, OP1, Osteogenic protein 1

SwissProt ID

G3V6W8, P18075 (Human), P23359 (Mouse), P30886, P34819 (Canfa)

Gene ID

655 (BMP7), 85272 (Bmp7)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Chk (Chicken), Por (Porcine), Rb (Rabbit), Ze (Zebrafish), Mky (Monkey)

Available hosts

Mouse, Rabbit, Goat, Chicken

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Functional assay (FN), ELISA (detection) (E(detection)), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Frozen Sections (C), Neutralisation (NEUT)

Background of BMP7 antibody

Bone morphogenetic proteins (BMPs) are a group of approximately 15 structurally related proteins belonging to the TGF-beta protein family. One member of this family is bone morphogenetic protein 7 (BMP-7). BMP-7 is a 431 amino acid protein that exists as a homodimer, linked by a single disulfide bond. BMP-7 is expressed in a wide variety of tissues including bone marrow, spleen, thymus, heart, muscle, liver, kidney pancreas, prostate and lung, in embryonic tissues, as well as in the central nervous system (including spinal cord). BMP-7 plays a major role in bone growth (osteogenesis) and regeneration by inducing collagen production in osteoblasts, the differentiation of stem cells and organogenesis during embryogenesis. BMP-7 is also involved in the chemotaxis of monocytes and has neuroprotective and neurogenesis properties. BMP-7 may be used in the treatment of wound healing, tissue repair and bone fractures, for neuroprotection and neurogenesis in the CNS and in nerve or spinal injuries. This is a HCX protein. HCX Expression System Details HCX proteins mimic the proteins in the human body because they are expressed from human, rather than animal, insect or bacterial cells. This process gives them human post-translational modifications. Recombinant DNA techniques allow a human protein with the correct amino acid sequence to be expressed in a non-human cell line. However, non-human cells lack the appropriate cellular machinery, such as specific glycosyltransferases, necessary to produce the correct human post-translational modifications of a protein. An extreme example is seen in E. coli cells, which produce recombinant proteins with no glycosylation, as the above figure illustrates. Rodent and yeast cells are able to glycosylate proteins, but they are still different from glycosylation in human cells. Expression System Resultant Proteins Human (e.g. K562, HEK293) Correct amino acid sequence Human post-translational modifications Rodent (e.g. CHO, NSO) Correct amino acid sequence Some natural glycosylation - not human-like Yeast (e.g. Pichia) Correct amino acid sequence Some natural glycosylation - not human-like E.Coli Correct amino acid sequence No PTMs Although there have been significant attempts to make non-human cell derived cytokines more human-like, there is a growing awareness that in many instances, particularly in therapeutics, cytokines should mimic those found in the body as closely as possible.

General readings

Gregory KE., et al. (2005) J. Biol, Chem. 280, 27970-27980.
Sampath TK., et al. (1990) J. Biol. Chem. 265, 13198-13205.
Godin RE., et al. (1998) Development. 125, 3473-3482.
Groppe J., et al. (2002) Nature. 420, 636-642.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

BMP7 antibody

BMP7 monoclonal antibody (M01), clone M1-F8. Western Blot analysis of BMP7 expression in human uterus myoma. Mouse IgG1 M1-F8 Purified Hu, Ms E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

BMP7 antibody

BMP7 monoclonal antibody (M03), clone S52. Western Blot analysis of BMP7 expression in human ovary cancer. Mouse IgG1 S52 Purified Hu, Ms E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

BMP7 antibody

Western blot analysis of Prostate cell and Kidney cell lysate using BMP7 antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

BMP7 antibody

IHC of human breast invasive ductal carcinoma.  The recommended concentration is 0.25 ug/ml with an overnight incubation at 4C.  An HRP-labeled polymer detection system was used with a DAB chromogen.  Heat induced antigen retrieval with a pH 6.0 sodium citrate buffer is recommended. Optimal concentrations and conditions may vary. Rabbit IgG Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

BMP7 antibody

WB Suggested Anti-Bmp7 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: Rat Lung Rabbit IgG Purified Hu, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

BMP7 antibody

WB Suggested Anti-BMP7 Antibody Titration: 1.25ug/ml; ELISA Titer: 1:1562500; Positive Control: Transfected 293T Rabbit IgG Purified Hu P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

BMP7 antibody

BMP7 Mouse IgG1 Azide Free Hu E
0.5 mg / €220.00
  Acris Antibodies GmbH

BMP7 antibody

BMP7 Rabbit Biotin Hu E, WB
50 µg / €340.00
  Acris Antibodies GmbH

BMP7 antibody

BMP7 Rabbit Biotin Hu E, WB
25 µg / €230.00
  Acris Antibodies GmbH

BMP7 antibody

BMP7 Rabbit Purified Hu E, FN, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

BMP7 antibody

BMP7 Rabbit Purified Hu E, FN, WB
50 µg / €230.00
  Acris Antibodies GmbH

BMP7 (N-term) antibody

Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu ICC/IF, P, WB

Regular Price: 0.4 ml / €370.00

Special Price: 0.4 ml / €231.00

  Acris Antibodies GmbH

BMP7 antibody

Immunohistochemistry (IHC) analyzes of BMP-7 antibody (Cat.-No.: AP20768PU-N) in paraffin-embedded human tonsil tissue. Rabbit Aff - Purified Hu, Ms, Rt P
0.1 mg / €350.00
  Acris Antibodies GmbH

BMP7 antibody

Western Analysis of anti-Human BMP7 antibody. Sample was loaded in 15% SDS-polyacrylamide gel under reducing conditions. 
Left panel: Molecular Standard. 
Right panel: rh BMP-7 derived from E. coli. Rabbit IgG Purified Hu WB
0.2 mg / €370.00
  Acris Antibodies GmbH

BMP7 antibody

Western Analysis of anti-Human BMP7 antibody. Sample was loaded in 15% SDS-polyacrylamide gel under reducing conditions. 
Left panel: Molecular Standard. 
Right panel: rh BMP-7 derived from E. coli. Rabbit IgG Purified Hu WB
0.1 mg / €270.00
  Acris Antibodies GmbH

BMP7 (N-term) antibody

BMP7 Rabbit Purified Hu E
1 ml / €490.00
  Acris Antibodies GmbH

BMP7 antibody

Western blot analysis:  The extracts of mouse kidney (MK) and rat heart (RH) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human BMP7 antibody (1:1,000). Protein was visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG1 4E7 Purified Hu, Ms, Rt E, WB
0.1 ml / €310.00
  Acris Antibodies GmbH

BMP7 antibody

Western blot analysis:  The extracts of mouse kidney (MK) and rat heart (RH) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human BMP7 antibody (1:1,000). Protein was visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG1 4E7 Purified Hu, Ms, Rt E, WB
50 µl / €230.00
  Acris Antibodies GmbH

BMP7 antibody

BMP7 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

BMP7 antibody

Western Blot analysis of BMP7 expression in transfected 293T cell line (H00000655-T01) by BMP7 MaxPab polyclonal antibody.

Lane 1: BMP7 transfected lysate(45.32 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

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