BMP8B antibody

Principal name

BMP8B antibody

Alternative names for BMP8B antibody

Bone morphogenetic protein 8B, BMP-8B, OP2, Osteogenic protein 2

SwissProt ID

P34820 (Human), P55105 (Mouse)

Gene ID

656 (BMP8B)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Rb (Rabbit), Ze (Zebrafish)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Dot blot (Dot)

Background of BMP8B antibody

The Bone morphogenetic proteins (BMPs) are members of the TGF-beta superfamily of cytokines that are involved in development, differentiation, and disease. The transforming growth factor-beta (TGF-beta) super-family consists of a large number of growth and differentiation factors, such as TGF-betas, activins, inhibins, growth and differentiation factors (GDFs), and bone morphogenetic proteins (BMPs). These TGF beta ligands act through specific serine/threonine type I and Type II receptor kinases (1). These type I and II receptor kinases subsequently activate Smad proteins, which then propagate the signals into the nucleus to regulate target gene expression. Several BMP isotypes have been identified (BMP1 through BMP16) have been recovered through molecular cloning. Recombinant protein products from several of these clones (BMP2-BMP16) are members of the TGF-beta super-family of regulatory ligands. There exist high degree of amino acid sequence homology between BMP5, BMP6, and BMP7, that constitute a subfamily within the BMPs. The signaling systems of BMP are highly conserved from flies to mammals and have been shown to be important in the development of multiple organs.
There are 2 variants fond in the BMP8 family (BMP8A and BMP8B). BMP8 is also known as osteonegenic protein 2 (OP 2). Closely related BMPs may use the same or different receptor complexes for signaling in a time- and space-dependent manner during development and differentiation. The BMP8 signaling requires involvement of mother-against-dpp (MAD) related protein 1 (MADr1) signaling pathway as a down stream component during meiotic male germ cell differentiation (1). The Bmp8 gene is expressed in developing skeletal tissue and maps near the Achondroplasia locus on mouse chromosome 4 (2). BMP8 Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. It also plays a role in calcium regulation and bone homeostasis.

General readings

General / background references:Peng C The TGF-beta superfamily and its roles in the human ovary and placenta. J Obstet Gynaecol Can 25:834-44 (2003). PubMed PMID: 14532952
Fan X et al. Spatial and temporal patterns of expression of Noggin and BMP4 in embryonic and postnatal rat hippocampus. Brain Res Dev Brain Res 146:51-8 (2003). PubMed PMID: 14643011
Thompson DL et al. Retinoic acid repression of bone morphogenetic protein 4 in inner ear development. Mol Cell Biol 23:2277-86 (2003). PubMed PMID: 12640113
Masuhara K et al. Use of monoclonal antibody to detect bone morphogenetic protein-4 (BMP-4). Bone 16:91-6 (1995). PubMed PMID: 7742091

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

BMP8B antibody

Western blot analysis of extracts from 293 cells and A549 cells, using BMP8B antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

BMP8B antibody

Host: Rabbit; Target Name: BMP8B; Sample Tissue: NCI-H226 Whole Cell lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

BMP8B antibody

Fig. 1: The extract of  A549 (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human BMP8b antibody (1:500). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.
Fig. 2: The Human Recombinant protein BMP8b(200, 100, 50ng) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human BMP8bq antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG2a AT13E6 Purified Hu E, WB
0.1 ml / €310.00
  Acris Antibodies GmbH

BMP8B antibody

Fig. 1: The extract of  A549 (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human BMP8b antibody (1:500). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.
Fig. 2: The Human Recombinant protein BMP8b(200, 100, 50ng) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human BMP8bq antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG2a AT13E6 Purified Hu E, WB
50 µl / €220.00
  Acris Antibodies GmbH

BMP8B (31-46) antibody

AP07895PU-N BMP8B antibody staining of Formalin-Fixed Paraffin-Embedded Human Skin at 5 µg/ml followed by biotinylated Goat anti-Rabbit IgG secondary antibody, Alkaline Phosphatase-Streptavidin and Chromogen. Rabbit Purified Hu E, P
50 µg / €470.00
  Acris Antibodies GmbH

BMP8B antibody

BMP8B Rabbit Aff - Purified Hu, Ms, Rt Dot, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

BMP8B antibody

Immunohistochemistry (IHC) analyzes of BMP-8 antibody (Cat.-No.: AP20771PU-N) in paraffin-embedded human testis tissue. Rabbit Aff - Purified Hu P
0.1 mg / €350.00
  Acris Antibodies GmbH

BMP8B antibody

BMP8B Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

BMP8B antibody

Detection limit for recombinant GST tagged BMP8B is approximately 0.03ng/ml as a capture antibody. Mouse IgG2a 6D6 Purified Hu E, WB
50 µg / €370.00
  Abnova Taiwan Corp.

BMP8B antibody

BMP8B Mouse IgG2a 6D6 Ascites Hu E, WB
0.2 ml / €370.00
  Abnova Taiwan Corp.

BMP8B antibody

Western blot analysis of extracts from 293/A549 cells, using BMP8B Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
50 µg / €205.00
  Assay Biotech

BMP8B antibody

Western blot analysis of extracts from 293/A549 cells, using BMP8B Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
0.1 mg / €310.00
  Assay Biotech

BMP8B antibody

Western blot analysis of BMP8B expression in HeLa (A); A549 (B); SKNSH (C) whole cell lysates. Rabbit Aff - Purified Hu WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

BMP8B antibody

Western blot analysis of BMP8B expression in HeLa (A); A549 (B); SKNSH (C) whole cell lysates. Rabbit Aff - Purified Hu WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

BMP8B antibody

Western blot analysis of BMP8B expression in HeLa (A); A549 (B); SKNSH (C) whole cell lysates. Rabbit Aff - Purified Hu WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

BMP8B antibody

BMP8B Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

BMP8B antibody

BMP8B Rabbit IgG Aff - Purified Hu E, WB
0.1 mg / €360.00
  Novus Biologicals Inc.

BMP8B antibody

BMP8B Rabbit IgG Aff - Purified Hu E, WB
50 µg / €290.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

BMP8B (264-402, His-tag)

BMP8B Human Purified > 90 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

BMP8B (264-402, His-tag)

BMP8B Human Purified > 90 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

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