BNIP3L / BNIP3A antibody

Principal name

BNIP3L / BNIP3A antibody

Alternative names for BNIP3L / BNIP3A antibody

BNIP3H, NIX, NIP3-like protein X, BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A, Adenovirus E1B19K-binding protein B5, BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like

SwissProt ID

O60238 (Human), Q3T013 (Bovin), Q9Z2F7 (Mouse)

Gene ID

665 (BNIP3L), 12177 (Bnip3l)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Frozen Sections (C)

Background of BNIP3L / BNIP3A antibody

Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, Hrk, Nip3, and Bim, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designatedBnip3L, Bnip3a, and Nix (for Nip3-like protein X) (Matsushima, M. et al.; Yasuda, M. et al.; Chen, G, et al.). Bnip3L/Bnip3a/Nix is a homolog of the E1B 19K/Bcl-2binding and pro-apoptotic protein Bnip3. Overexpression of Bnip3L induces apoptosis (Yasuda, M. et al.; Chen, G, et al.). Bnip3L interacts with and overcomes suppresses by Bcl-2 and Bcl-xL. Bnip3Lis localized in mitochondria. The messenger RNA ofBnip3L is ubiquitously expressed in human tissues (Matsushima, M. et al.; Yasuda, M. et al.). Bnip3L and Bnip3 form a new subfamily of the pro-apoptotic mitochondrial proteins.

General readings

This product has been used in:Passer BJ et al. The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase. Proc Natl Acad Sci U S A 100:2284-9 (2003). PubMed PMID: 12606722
General / background references:Yasuda M et al. BNIP3alpha: a human homolog of mitochondrial proapoptotic protein BNIP3. Cancer Res 59:533-7 (1999). PubMed PMID: 9973195
Chen G et al. Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins. J Biol Chem 274:7-10 (1999). PubMed PMID: 9867803
Imazu T et al. Bcl-2/E1B 19 kDa-interacting protein 3-like protein (Bnip3L) interacts with bcl-2/Bcl-xL and induces apoptosis by altering mitochondrial membrane permeability. Oncogene 18:4523-9 (1999). PubMed PMID: 10467396
Matsushima M et al. Isolation, mapping, and functional analysis of a novel human cDNA (BNIP3L) encoding a protein homologous to human NIP3. Genes Chromosomes Cancer 21:230-5 (1998). PubMed PMID: 9523198
Passer BJ et al. The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase. Proc Natl Acad Sci U S A 100:2284-9 (2003). PubMed PMID: 12606722

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

BNIP3L / BNIP3A antibody

Western blot analysis using anti-Bnip3L (IN) antibody at 1 µg/ml on K562 whole cell lysate in the absense (1) and presense (2) of immunogenic peptide. Rabbit IgG Purified Hu WB
0.1 mg / €370.00
  Acris Antibodies GmbH

BNIP3L / BNIP3A (Center) antibody

Confocal immunofluorescent analysis of BNIP3L / BNIP3A Antibody (Center) Cat.-No AP52881PU-N with A549 cell followed by Alexa Fluor®488-conjugated goat anti-rabbit lgG (green). Actin filaments have been labeled with Alexa Fluor 555 phalloidin (red). DAPI was used to stain the cell nuclear (blue). Rabbit Ig Aff - Purified Hu F, ICC/IF, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

BNIP3L / BNIP3A antibody

AP15371PU Bnip3L antibody staining of Human Breast Carcinoma. Rabbit Purified Hu P
0.5 ml / €360.00
  Acris Antibodies GmbH

BNIP3L / BNIP3A antibody

AP15371PU Bnip3L antibody staining of Human Breast Carcinoma. Rabbit Purified Hu P
1 ml / €520.00
  Acris Antibodies GmbH

BNIP3L / BNIP3A antibody

AP15371PU Bnip3L antibody staining of Human Breast Carcinoma. Rabbit Purified Hu P
0.1 ml / €190.00
  Acris Antibodies GmbH

BNIP3L / BNIP3A antibody

Western blot analysis of Bnip3L in K562 whole cell lysate in the absence (A), or presence (B) of immunogenic peptide (2289P) with Bnip3L antibody (IN) at 1 ug/ml. Rabbit IgG Purified Hu ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

BNIP3L / BNIP3A antibody

Immunohistochemistry: BNIP3L Antibody [TA336844] - Analysis of BNIP3L in mouse prostate using DAB with hematoxylin counterstain. Rabbit Purified Hu, Ms C, ICC/IF, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

BNIP3L / BNIP3A antibody

Figure 1. Formalin-Fixed Paraffin-Embedded (FFPE) on Kidney. Rabbit Aff - Purified Hu P, WB
50 µg / €470.00
  Acris Antibodies GmbH

BNIP3L / BNIP3A antibody

BNIP3L / BNIP3A Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

BNIP3L / BNIP3A antibody

Western Blot analysis of BNIP3L expression in transfected 293T cell line (H00000665-T02) by BNIP3L MaxPab polyclonal antibody.

Lane 1: BNIP3L transfected lysate(23.90 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

BNIP3L / BNIP3A antibody

Detection limit for recombinant GST tagged BNIP3L is approximately 0.1ng/ml as a capture antibody. Mouse IgG1 3G2 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

BNIP3L / BNIP3A antibody

BNIP3L / BNIP3A Mouse IgG1 2E11 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

BNIP3L / BNIP3A antibody

Formalin-fixed and paraffin-embedded human breast cancer tissue reacted with BNIP3L/BNIP3 polyclonal antibody ( Cat # PAB1863 ) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Hu, Ms E, ICC/IF, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

BNIP3L / BNIP3A antibody

Western blot analysis of BNIP3L expression in K-562 whole cell lysate with anti-BNIP3L ( IN ) antibody at 1 µg/ml. Rabbit Hu WB
0.1 mg / €470.00
  Abnova Taiwan Corp.

BNIP3L / BNIP3A antibody

BNIP3L / BNIP3A Rabbit Hu P
0.1 ml / €390.00
  Abnova Taiwan Corp.

BNIP3L / BNIP3A (Center) antibody

Mouse Spleen; WB Suggested Anti-Bnip3l Antibody. . Titration: 1.0 ug/ml. . Positive Control: Mouse Spleen; Bnip3l antibody - middle region (ARP58878_P050) in Mouse Spleen cells using Western Blot Rabbit Aff - Purified Hu, Ms WB
50 µg / €350.00
  AVIVA Systems Biology

BNIP3L / BNIP3A antibody

Western Blot: Bnip 3L Antibody [NB600-1155] - Western blot analysis of Bnip3L in K562 whole cell lysate in the absence (A), or presence (B) of immunogenic peptide with anti- Bnip3L at 1 ug/ml. Rabbit IgG Aff - Purified Hu, Ms P, WB
50 µg / €360.00
  Novus Biologicals Inc.

BNIP3L / BNIP3A antibody

Western Blot: BNIP3L Antibody [NBP1-47307] - Detection of Human BNIP3L by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells.   Antibodies: Affinity purified rabbit anti-BNIP3L antibody used for IP at 3 mcg/mg lysate.  BNIP3L was also immunoprecipitated by rabbit anti-BNIP3L antibody, which recognizes a downstream epitope.  For blotting immunoprecipitated BNIP3L was used at 1 mcg/ml.   Detection: Chemiluminescence with an exposure time of 30 seconds. Rabbit Aff - Purified Hu IP
0.1 mg / €440.00
  Novus Biologicals Inc.

BNIP3L / BNIP3A antibody

Western Blot: BNIP3L Antibody [NBP1-47308] - Detection of Human BNIP3L by Western Blot of Immunoprecipitates.  Samples:  Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells.   Antibodies: Affinity purified rabbit anti-BNIP3L antibody used for IP at 3 mcg/mg lysate.  BNIP3L was also immunoprecipitated by rabbit anti-BNIP3L antibody, which recognizes an upstream epitope.  For blotting immunoprecipitated BNIP3L was used at 1 mcg/ml.  Detection: Chemiluminescence with an exposure time of 30 seconds. Rabbit Aff - Purified Hu IP
0.1 mg / €440.00
  Novus Biologicals Inc.

BNIP3L / BNIP3A antibody

BNIP3L / BNIP3A Rabbit Aff - Purified Hu E, P, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

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