BOC antibody

Principal name

BOC antibody

Alternative names for BOC antibody

Brother of CDO, Protein BOC

SwissProt ID

Q6AZB0 (Mouse), Q9BWV1 (Human)

Gene ID

91653 (BOC), 117606 (Boc)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Goat, Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C)

Background of BOC antibody

BOC(Brother Of CDO) also known as BROTHER OF CDON and BOC are cell surface receptors of the immunoglobulin (Ig)/fibronectin type III repeat family involved in myogenic differentiation. CDON and BOC are coexpressed during development, form complexes with each other in a cis fashion, and are related to each other in their ectodomains, but each has a unique long cytoplasmic tail. The domain structure of BOC is similar to that of CDON, and the 2 proteins share 38 to 80% amino acid identity in the individual extracellular domains. The International Radiation Hybrid Mapping Consortium mapped the BOC gene to chromosome 3. In contrast with CDON, the intracellular region of BOC was not essential for its ability to positively regulate differentiation.BOC is dependent on CDON for activity and that CDON-BOC complexes function to regulate myogenic differentiation. Wegorzewska et al. (2003) proposed that CDO and BOC play a role in the inverse relationship between differentiation and transformation of cells in the skeletal muscle lineage.BOC is expressed by commissural neurons, and targeted disruption of BOC in mouse resulted in the misguidance of commissural axons toward the floor plate.

General readings

Okada A, Charron F, Morin S, Shin DS, Wong K, Fabre PJ, Tessier-Lavigne M, McConnell SK.
Boc is a receptor for sonic hedgehog in the guidance of commissural axons.
Nature. 2006 Nov 16;444(7117):369-73. Epub 2006 Nov 1.
PMID: 17086203

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

BOC antibody

  Goat Polyclonal Antibody against BOC  
TA303353 (0.3µg/ml) staining of Human Ileum lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €360.00
  OriGene Technologies, Inc.

BOC antibody

BOC Goat IgG Aff - Purified Ms, Rt C, E, WB
0.1 mg / €450.00
  Neuromics Antibodies

2 Item(s)

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