BOP1 antibody

Principal name

BOP1 antibody

Alternative names for BOP1 antibody

KIAA0124, Ribosome biogenesis protein BOP1, Block of proliferation 1 protein

SwissProt ID

P83107 (Bovin), P97452 (Mouse), Q14137 (Human)

Gene ID

23246 (BOP1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), African clawed frog, Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit), Ye (Yeast), Ze (Zebrafish)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Immunoprecipitation (IP), Paraffin Sections (P)

Background of BOP1 antibody

Predominantly localized to the nucleolus, BOP1 (Block of proliferation 1 protein) is a 746 amino acid highly conserved non-ribosomal protein that is involved in ribosome biogenesis. Truncation of the amino terminus of BOP1 leads to cell growth arrest in the G1 phase and specific inhibition of 28S and 5.8S rRNA synthesis, as well as a deficit in the cytosolic 60S ribosomal subunit. This suggests that BOP1 is involved in the formation of mature rRNAs and in the biogenesis of the 60S ribosomal subunit. BOP1 physically interacts with pescadillo (a protein involved in cell proliferation) and enables efficient incorporation of pescadillo into the nucleolar preribosomal complexes, thereby affecting rRNA maturation and the cell cycle. The BOP1-pescadillo complex is also necessary for biogenesis of 60S ribosomal subunits. Deregulation of BOP1 may lead to colorectal tumorigenesis.

General readings

Ewing,R.M., Mol. Syst. Biol. 3, 89 (2007)

9 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

BOP1 antibody

WB Suggested Anti-BOP1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 12500; Positive Control: HT1080 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Por, Rb, Rt, Ye WB
50 µg / €325.00
  OriGene Technologies, Inc.

BOP1 antibody

WB Suggested Anti-BOP1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: Transfected 293T Rabbit IgG Purified Can, Eq, Hu, Ms, Por, Rb, Rt, Ye, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

BOP1 antibody

Human HT1080; WB Suggested Anti-BOP1 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:12500. Positive Control: HT1080 cell lysate; BOP1 antibody - N-terminal region (ARP46224_P050) in Human HT1080 cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

BOP1 antibody

Transfected 293T; WB Suggested Anti-BOP1 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: Transfected 293T; BOP1 antibody - N-terminal region (ARP46225_P050) in Transfected 293T cells using Western Blot Rabbit Aff - Purified African clawed frog, Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

BOP1 antibody

Western Blot and  Immunoprecipitation: BOP1 Antibody [NBP1-21388]- on HeLa whole cell lysate using affinity purified rabbit anti-BOP1 antibody. BOP1 was  also immunoprecipitated by rabbit anti-BOP1 antibody  NBP1-21389. Rabbit IgG Aff - Purified Hu IP, WB
0.1 ml / €440.00
  Novus Biologicals Inc.

BOP1 antibody

Immunohistochemistry-Paraffin: BOP1 Antibody [NBP1-21389] - FFPE section of human colon carcinoma. Antibody: Affinity purified rabbit anti-BOP1 used at a dilution of 1:250. Detection: DAB staining using Immunohistochemistry Accessory Kit. Rabbit IgG Aff - Purified Hu IP, P, WB
0.1 ml / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

BOP1

BOP1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

BOP1

BOP1 Human Purified
2 µg / €300.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

BOP1 overexpression lysate

BOP1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

9 Item(s)

per page
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