BPI antibody

Principal name

BPI antibody

Alternative names for BPI antibody

CAP57, Bactericidal permeability-increasing protein

SwissProt ID

P17213 (Human)

Gene ID

671 (BPI)

Available reactivities

Hu (Human), Ms (Mouse)

Available hosts

Rabbit, Mouse, Goat

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), Flow Cytometry (F), Enzyme Immunoassay (E), Functional assay (FN), Immunoprecipitation (IP)

Background of BPI antibody

The antimicrobial protein BPI is a 55 kDa protein found in the primary (azurophilic) granules of human neutrophils and has also been detected on surface of neutrophils, small intestinal and oral epithelial cells. BPI is a bactericidal compound that is present in polymorphonuclear cells (PMN) and in lower levels in the specific granules of eosinophils. BPI possesses high affinity toward the lipid A region of lipopolysaccharides (LPS) that comprise the outer leaflet of the gram-negative bacterial outer membrane. Binding of BPI to the lipid A moiety of LPS exerts multiple anti-infective activities against gram-negative bacteria: 1) cytotoxicity via sequential damage to bacterial outer and inner lipid membranes, 2) neutralization of gram-negative bacterial LPS, 3) opsonization of bacteria to enhance phagocytosis by neutrophils. Airway epithelial cells constitutively express the BPI gene and produce the BPI protein and, therefore, BPI may be a critical determinant in the development of LPS-triggered airways disease. Inflammation induced by LPS possibly contributes to the development of rapid airflow decline, a serious and often fatal complication of hematopoietic cell transplantation. Furthermore, a 21 kDa bioactive recombinant fragment of BPI, rBPI21, was shown to confer a survival advantage against invasive pneumococcal disease by binding to the gram-positive bacterial pathogen, pneumolysin.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

BPI antibody

  Rabbit anti-BPI Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using BPI antibody. Rabbit IgG Purified Hu, Ms
0.1 mg / €325.00
  OriGene Technologies, Inc.

BPI antibody

  Goat Polyclonal Anti-BPI Antibody  
TA348932 (0.3 ug/ml) staining of Human Bone Marrow lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

BPI antibody

  Rabbit Polyclonal Anti-BPI Antibody  
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using (BPI Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200) Rabbit IgG Purified Hu E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

BPI antibody

BPI Mouse IgG1 GE 4.90 Purified Hu E, FN
0.1 mg / €500.00
  Acris Antibodies GmbH

BPI antibody

BPI Mouse IgG1 4H5 Purified Hu E
0.1 mg / €500.00
  Acris Antibodies GmbH

BPI antibody

BPI Mouse IgG1 3F9 Purified Hu E
0.1 mg / €500.00
  Acris Antibodies GmbH

BPI antibody

BPI Rabbit IgG Purified E, IP
0.1 mg / €460.00
  Acris Antibodies GmbH

BPI (Center) antibody

Formalin-fixed and paraffin-embedded human tonsil tissue reacted with BPI Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu F, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

BPI - human gene knockout kit via CRISPR

BPI - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

BPI - human gene knockout kit via CRISPR

BPI - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

BPI - human gene knockout kit via CRISPR

BPI - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

BPI - human gene knockout kit via CRISPR

BPI - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

BPI

  Recombinant protein of human bactericidal/permeability-increasing protein (BPI)  
BPI Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

BPI

  Purified recombinant protein of Human bactericidal/permeability-increasing protein (BPI)  
BPI Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
10 µg / €139.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

BPI overexpression lysate

BPI overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

15 Item(s)

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