BRCC3 antibody

Principal name

BRCC3 antibody

Alternative names for BRCC3 antibody

BRCC36, C6.1A, CXorf53, Lys-63-specific deubiquitinase BRCC36, BRCA1-A complex subunit BRCC36, BRISC complex subunit BRCC36, BRCA1/BRCA2-containing complex subunit 3, BRCA1/BRCA2-containing complex subunit 36

SwissProt ID

P46736 (Human), P46737 (Mouse)

Gene ID

79184 (BRCC3), 5791840 (ate)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunoprecipitation (IP), Flow Cytometry (F), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of BRCC3 antibody

Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex.

General readings

Wang Bin, et al., (2007) Proc Natl Acad Sci USA 104(52):20759-20763.
Chen Xiaowei, et al., (2006) Cancer Research 66:5039-5046.
Dong Y, et al., (2003) Mol Cell 12(5):1087-1099.

18 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

BRCC3 antibody

Western blot analysis of BRCC36 in MCF7 cell lysate with BRCC36 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

BRCC3 antibody

Immunohistochemistry: AM09089PU-N BRCC3 antibody staining of Formalin-Fixed, Paraffin-Embedded Human Spleen followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen. Mouse IgG1 AT3B1 Purified Hu E, P, WB
0.1 ml / €310.00
  Acris Antibodies GmbH

BRCC3 antibody

Immunohistochemistry: AM09089PU-N BRCC3 antibody staining of Formalin-Fixed, Paraffin-Embedded Human Spleen followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen. Mouse IgG1 AT3B1 Purified Hu E, P, WB
50 µl / €230.00
  Acris Antibodies GmbH

BRCC3 antibody

Formalin fixed, paraffin embedded human brain stained with Rabbit anti Human BRCC36 (AP05726SU-N) following heat mediated antigen retrieval using sodium citrate buffer (pH6.0) Rabbit IgG Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

BRCC3 antibody

Skeletal muscle: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

BRCC3 Control Peptide

BRCC3
50 µg / €160.00
  Acris Antibodies GmbH

BRCC3 antibody

BRCC3 Mouse Purified Hu E(detection), ICC/IF, WB
50 µg / €370.00
  Abnova Taiwan Corp.

BRCC3 antibody

Immunohistochemistry of BRCC3 in human brain tissue with BRCC3 polyclonal antibody ( Cat # PAB13012 ) at 2.5 µg/ml. Rabbit Hu, Ms, Rt P, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

BRCC3 antibody

BRCC3 Rabbit Aff - Purified Hu, Ms, Rt P, WB
50 µg / €480.00
  Novus Biologicals Inc.

BRCC3 antibody

BRCC3 Mouse IgG1 AT3B1 Hu E, WB
0.1 ml / €380.00
  Novus Biologicals Inc.

BRCC3 antibody

Western Blot: BRCC3 Antibody [NBP1-76831] - Analysis of BRCC36 in MCF7 cell lysate with BRCC36 antibody at (A) 0.5, (B) 1 and (C) 2 ug/mL. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

BRCC3 antibody

Western Blot: BRCC3 Antibody (EPR4366) [NBP1-95548] - 7, (C) SKBR-3, and (D) 293T cell lysates using anti-BRCC36. Rabbit EPR4366 Purified Hu, Ms, Rt E, F, IP, WB
0.1 ml / €480.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

BRCC3

BRCC3 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

BRCC3

BRCC3 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

BRCC3 293T Cell Transient Overexpression Lysate(Denatured)

BRCC3 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

Lysates (Overexpressed)

Catalog No.    

BRCC3 overexpression lysate

BRCC3 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

BRCC3 overexpression lysate

BRCC3 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

BRCC3 overexpression lysate

BRCC3 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

18 Item(s)

per page
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