BRICK1 / C3orf10 antibody

Principal name

BRICK1 / C3orf10 antibody

SwissProt ID

Q8WUW1 (Human), Q91VR8 (Mouse)

Gene ID

55845 (BRK1)

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Ms (Mouse), Rt (Rat), Ze (Zebrafish), African clawed frog, Eq (Equine), Por (Porcine)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Enzyme Immunoassay (E)

Background of BRICK1 / C3orf10 antibody

HSPC300 (hematopoietic stem cell protein 300) is also known as probable protein BRICK1 or C3orf10 (chromosome 3 open reading frame 10) and is a 75 amino acid protein that is expressed as two isoforms and localizes to both the cytoplasm and the cytoskeleton. HSPC300 is thought to regulate cytoskeletal organization and Actin polymerization. Free HSPC300 exists as homotrimers prior to its incorporation into the WAVE complex. The WAVE complex includes five proteins, one of which is HSPC300, that regulate the ARC (Arp2/3 complex) which is responsible for Actin nucleation and is Rac 1-dependent. Because HSPC300 is a highly conserved subunit of the WAVE complex across many species, it is thought to have the same or similar functions in many different organisms. In Drosophila, the WAVE/ARC pathway may affect the development of the nervous system. HSPC300 is thought to localize to axons of the central nervous system of Drosophila embryos and thus may also be involved in axonogenesis. In addition, HSPC300 is thought to be necessary for synaptic morphogenesis by motoneurons. In mice, the knockout of the WAVE complex leads to learning and memory defects, and it is therefore hypothesized that HSPC300 may also be involved in cognitive functions. Genetic depletion of HSPC300 results in cytoskeletal abnormalities and prevents cytokinesis of cells, suggesting that decreased levels of HSPC300 may be associated with tumor suppression.

General readings

Eden S, Rohatgi R, et al. (2002). Nature. 418(6899):790-3.
Cascón A, Escobar B, et al. (2007). Hum Mutat. 28(6):613-21.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

BRICK1 / C3orf10 antibody

WB Suggested Antibody Titration: 2.5 ug/ml; Positive Control: HepG2 Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rt, Ze P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

BRICK1 / C3orf10 antibody

Human Liver; C3orf10 antibody - middle region (ARP51212_T100) in Human Liver cells using Immunohistochemistry Rabbit Aff - Purified African clawed frog, Bov, Can, Hu, Ms, Rt, Ze P, WB
0.1 mg / €310.00
  AVIVA Systems Biology

BRICK1 / C3orf10 antibody

Western Blot: C3orf10 Antibody [NBP1-56944] - This Anti-C3orf10 antibody was used in Western Blot of HepG2 tissue lysate at a concentration of 2.5ug/ml. Rabbit Purified Can, Hu, Ms, Rt, Ze P, WB
0.1 mg / €360.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

BRICK1 / C3orf10

BRICK1 / C3orf10 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

BRICK1 / C3orf10 (1-75, His-tag)

BRICK1 / C3orf10 Human Purified > 90 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

BRICK1 / C3orf10 (1-75, His-tag)

BRICK1 / C3orf10 Human Purified > 90 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

BRICK1 / C3orf10

BRICK1 / C3orf10 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

BRICK1 / C3orf10

BRICK1 / C3orf10 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

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