BRS3 antibody

Principal name

BRS3 antibody

Alternative names for BRS3 antibody

BRS-3, Bombesin receptor subtype-3

SwissProt ID

O54798 (Mouse), P32247 (Human), Q8K418 (Rat)

Gene ID

680 (BRS3)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey), Prim (Primate), Bt (Bat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Rb (Rabbit), Sh (Sheep), Bear, Hst (Hamster), Chk (Chicken)

Available hosts

Rabbit, Mouse

Available applications

Paraffin Sections (P), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of BRS3 antibody

Bombesin receptor 3 (BB3) is a member of a family of receptors that binds the 14 amino acid peptide bombesin. Bombesin was first isolated from frog skin and it was later established that mammalians express endogenous bombesin like peptides such as gastrin-releasing peptide (GRP) a 27 amino acid homologue and neuromedin B (NMB) a 10 amino acid homologue. BB1 is the preferred receptor for NMB while BB2 is the preferred receptor for GRP. BB3 was the third member of the bombesin receptors family to be cloned based in its sequence similarity to BB1 and BB2. The affinity of BB3 for bombesin is lower than that of the BB1 and BB2 receptors as is its affinity for NMB and GRP. This suggests that the mammalian endogenous ligand for the BB3 receptor remains to be identified. All three bombesin receptors are members of the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily. BB3 is coupled to a Gq/11 protein that activates phospholipase C (PLC) and leads to production of inositol 1,4,5-trisphosphate (InsP3), intracellular Ca2+ mobilization and cell growth. The physiological function of the BB3 receptor is not clear. However, studies with BB3 receptor deficient mice have shown that the mice develop mild obesity associated with hypertension and reduced metabolic rate. Filly, BB3 receptor expression has been identified in several human tumors most notably lung. BB3 is therefore considered a potential target for the development of both diagnostics and anti-cancer therapies.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

BRS3 antibody

Western blot analysis of rat brain membranes: 1. Anti-Bombesin Receptor 3 (extracellular) antibody, (1:200). 2. Anti-Bombesin Receptor 3 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

BRS3 antibody

Western blot analysis of extracts from HUVEC cells, using BRS3 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

BRS3 antibody

Western blot analysis of extracts from HUVEC cells, using BRS3 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

BRS3 (N-term) antibody

Anti-BRS3 antibody IHC of human placenta, villi. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu, Ms, Rt P
50 µg / €379.00
  OriGene Technologies, Inc.

BRS3 (C-term) antibody

Anti-BRS3 antibody IHC of human placenta, villi. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu P
50 µg / €379.00
  OriGene Technologies, Inc.

BRS3 (2nd Extracell. Dom.) antibody

Anti-BRS3 antibody IHC of human pancreas, islet. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu, Mky, Prim P
50 µg / €379.00
  OriGene Technologies, Inc.

BRS3 (C-term, cytopl. dom.) antibody

Anti-BRS3 antibody IHC of human pancreas, islet. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bt, Elephant, Hu, Mky, Prim P
50 µg / €379.00
  OriGene Technologies, Inc.

BRS3 antibody

Anti-BRS3 antibody IHC of human uterus, pregnant. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu
50 µg / €379.00
  OriGene Technologies, Inc.

BRS3 (3rd cytopl. dom.) antibody

Brain: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Aff - Purified Bear, Bov, Bt, Can, Elephant, Eq, GP, Hst, Hu, Mky, Ms, Prim, Rb, Rt, Sh P
50 µg / €379.00
  OriGene Technologies, Inc.

BRS3 antibody

Western blot (WB) analysis of BRS-3 antibody (Cat.-No.: AP01209PU-N) in extracts from HUVEC cells. Rabbit Aff - Purified Hu ICC/IF, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

BRS3 antibody

Western blot (WB) analysis of BRS-3 antibody (Cat.-No.: AP01294PU-N) at 1/500 dilution Lane1:HEK293T cell lysate Lane2:NIH-3T3 cell lysate Lane3:H9C2 cell lysate Rabbit Aff - Purified Hu E, ICC/IF, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

BRS3 (N-term extracell. dom.) antibody

Brain, thalamus: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Aff - Purified Bear, Bov, Bt, Can, Eq, GP, Hu, Mky, Ms, Prim, Rb, Rt, Sh E, P
50 µg / €470.00
  Acris Antibodies GmbH

BRS3 (C-term cytopl. dom.) antibody

Brain, thalamus: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Aff - Purified Hu, Mky, Prim E, P
50 µg / €470.00
  Acris Antibodies GmbH

BRS3 (1st Cytopl. Dom.) antibody

Uterus, pregnant: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Aff - Purified Bear, Bov, Bt, Can, Chk, Elephant, Eq, GP, Hst, Hu, Mky, Ms, Op, Platypus, Prim, Rb, Rt, Sh, Tr, Xen E, P
50 µg / €470.00
  Acris Antibodies GmbH

BRS3 (Center) antibody

Western blot analysis of BRS3 Antibody (Center) (Cat. #AP50393PU-N) in mouse stomach tissue lysates (35µg/lane). BRS3 (arrow) was detected using the purified Pab Rabbit Ig Aff - Purified Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

BRS3 antibody

BRS3 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

BRS3 antibody

BRS3 Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

BRS3 antibody

Immunofluorescence analysis of A549 cells, using BRS3 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF, WB
50 µg / €205.00
  Assay Biotech

BRS3 antibody

Immunofluorescence analysis of A549 cells, using BRS3 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF, WB
0.1 mg / €310.00
  Assay Biotech

BRS3 antibody

Western blot analysis of extracts from HuvEc cells, using BRS3 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
50 µg / €205.00
  Assay Biotech

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