BRSK1 antibody

Principal name

BRSK1 antibody

Alternative names for BRSK1 antibody

KIAA1811, SAD1, SAD-B, BR serine/threonine-protein kinase 1, SAD1 kinase, Serine/threonine kinase SAD-B

SwissProt ID

Q5RJI5 (Mouse), Q8TDC3 (Human)

Gene ID

84446 (BRSK1), 381979 (Brsk1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of BRSK1 antibody

BRSK1 was initially identified as a mammalian homolog to the fission yeast S. pombe Cdr2, a mitosis-regulatory kinase and also shows significant homology to the C. elegans neuronal cell polarity regulator SAD1. BRSK1 is unbiquitously expressed, with highest levels of expression in the brain and testes. Similar to its yeast homolog, BRSK1 is thought to be involved in stress-induced cell cycle arrest. Overexpression of this protein leads to the G2/M arrest in HeLa S2 cells and UV-induced G2/M arrest could be partially abrogated by reduced expression of BRSK1 through the use of siRNA, indicating its role in DNA damage checkpoint function. More recently, it has been shown that both BRSK1 and the related protein BRSK2 are required for mammalian neuronal polarization. While BRSK1- and BRSK2-null mice were viable, double-mutant mice died within two hours of birth. Neurons from these mice showed uniformly-sized neurites as opposed to the normal long axon and multiple shorter dendrites. These neurites also displayed both axonal and dendritic markers. At least two isoforms of BRSK1 are known to exist.

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Lysates

Catalog No.    

BRSK1 overexpression lysate

BRSK1 overexpression lysate  
0.1 mg / €495.00
  OriGene Technologies, Inc.

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