BTBD7 antibody

Principal name

BTBD7 antibody

Alternative names for BTBD7 antibody

KIAA1525, BTB/POZ domain-containing protein 7

SwissProt ID

Q8CFE5, Q9P203

Gene ID

55727 (BTBD7), 238386 (Btbd7)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Por (Porcine), Eq (Equine), GP (Guinea Pig), Rb (Rabbit), Ye (Yeast), Ze (Zebrafish)

Available hosts

Rabbit, Goat, Mouse

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of BTBD7 antibody

Cancer cells especially human hepatocellular carcinoma (HCC) differentially express many genes as determined by cDNA microarrays. One of these genes is Btbd7 whose function was not known. When transfected in NIH3T3 cells this gene exhibited enhanced cell proliferation activity by MTT assay. The enhanced tumorigencity was blocked by anti-sense RNA experiments (1). Recently it has been shown that Btbd7 regulate epithelial cell dynamics and branching morphogenesis. The organ development during embryogenesis requires extensive branching of epithelia via formation of cleft and buds. These branches are developed by local outgrowth or by formation of cleft that further divide epithelia in to buds. The bud or tubule extension is controlled and regulated by various growth factors. These branching finally led to formation of various organs. Cellular matrix protein fibronectin is required for salivary, lung and kidney branching (3). The edges of fibronectin translocates inwards as cleft accompanied by loss of E-cadherin in cells adjacent to fibronectin. The Btbd7 activity was noticed at cell cleft forming sites (2). The cleft formation involves buds delineation of buds by conversion of epithelial cell-cell adhesion to cell-matrix adhesion. Btbd7 provides a mechanistic link between the extracellular matrix and cleft propagation via its highly discrete expression that control epithelial cell motility by interaction with other cellular architectural and scaffolding proteins like Snail2 (slug), E-cadherin (4). The Btbd7 antibodies were generated using peptide corresponding to C-terminal domain of the human Btbd7 gene. The Btbd7 antibodies are affinity purified over immobilized antigen based affinity chromatography, and the purified immunoglobulins are stabilized in antibody stabilization buffer. Antibodies to Btbd7 (Btbd-701AP) will label ~144kDa protein in Western blot positive control for Btbd7 (PC-Btbd7).

5 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

BTBD7 antibody

Host: Rabbit; Target Name: BTBD7; Sample Tissue: OVCAR-3 Whole Cell lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ye, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

BTBD7 (N-term) antibody

MDCK overexpressing Mouse Btbd7 (third lane) and probed with AP31918PU-N BTBD7 antibody (mock transfection in first lane, full construct chemically suppressed in second lane) Goat Aff - Purified Bov, Can, Hu, Ms, Por, Rt E, P
0.1 mg / €350.00
  Acris Antibodies GmbH

BTBD7 antibody

BTBD7 Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

BTBD7 antibody

BTBD7 Rabbit IgG Aff - Purified Hu, Ms WB
50 µg / €680.00
  Funakoshi Co., Ltd.


Catalog No.    

BTBD7 overexpression lysate

BTBD7 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

5 Item(s)

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