BTK antibody

Principal name

BTK antibody

Alternative names for BTK antibody

Bruton tyrosine kinase, AGMX1, ATK, BPK, Tyrosine-protein kinase BTK, Agammaglobulinaemia tyrosine kinase, B-cell progenitor kinase

SwissProt ID

P35991 (Mouse), Q06187 (Human), Q8JH64 (Chick)

Gene ID

695 (BTK)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey), Bov (Bovine), Can (Canine), Prim (Primate)

Available hosts

Rabbit, Mouse

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), Paraffin Sections (P), Frozen Sections (C), Flow Cytometry (F), Luminex (LMNX)

Background of BTK antibody

Brutons tyrosine kinase (BTK) is a member of the BTK/Tec family of cytoplasmic tyrosine kinases. Like other BTK family members, it contains a pleckstrin homology (PH) domain, Src homology SH3 and SH2 domains. BTK plays an important role in B cell development. Activation of B cells by various ligands is accompanied by BTK membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane located BTK is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinase, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation. The activation of BTK is negatively regulated by PKC beta through phosphorylation of BTK at Ser180, which results in reduced membrane recruitment, transphosphorylation and subsequent activation. The PKC/BTK inhibitory signal is likely to be a key determinant of the B cell receptor signaling threshold to maintain optimal BTK activity.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

BTK antibody

Immunohistochemical staining of paraffin-embedded Human liver tissue within the normal limits using anti-BTK mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501118, Dilution 1:50) Mouse IgG2a OTI10E10 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

BTK antibody

Western Blot: BTK Antibody (7F12H4) [TA336560] - Analysis of BTK expression in 1) truncated BTK recombinant protein and 2) K562 cell lysate. Mouse IgG1 7F12H4 Purified Hu, Prim C, E, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

BTK antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of liver tissue using anti-BTK mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501090, Dilution 1:50) Mouse IgG2a OTI12D4 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

BTK antibody

Immunohistochemical staining of paraffin-embedded liver tissue within the normal limits using anti-BTK mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501091, Dilution 1:50) Mouse IgG3 OTI12H4 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

BTK antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of liver tissue using anti-BTK mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501092, Dilution 1:50) Mouse IgG3 OTI3D11 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

BTK antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of prostate tissue using anti-BTK mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501093, Dilution 1:50) Mouse IgG2b OTI6H9 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

BTK antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of ovary tissue using anti-BTK mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501094, Dilution 1:50) Mouse IgG1 OTI3A2 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

BTK antibody

Immunohistochemical staining of paraffin-embedded Kidney tissue within the normal limits using anti-BTK mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501100, Dilution 1:50) Mouse IgG1 OTI3E9 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

BTK antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of liver tissue using anti-BTK mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501101, Dilution 1:50) Mouse IgG1 OTI1H7 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

BTK antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of liver tissue using anti-BTK mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501119, Dilution 1:50) Mouse IgG1 OTI15G8 Purified Hu F, ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

BTK (N-term) antibody

Western blot analysis of BTK in U937 cell lysate with BTK antibody at (A) 0.5, (B) 1, and (C) 2 ug/mL. Rabbit IgG Aff - Purified Hu, Ms E, ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

BTK antibody

Western Blot: BTK Antibody - WB analysis of BTKpY223 with peptide competition: 1. ab only, 2. 200 molar excess unmodified immunizing peptide and 3. 200 molar excess modified immunizing peptide. Rabbit Purified Hu, Ms C, ICC/IF, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

BTK antibody

Western blot analysis of extracts from Hela cells, using BTK (Ab-222) antibody (#TA313379, Line 1 and 2).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

BTK antibody

Western blot analysis of extracts of Daudi cell lines, using BTK antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

BTK antibody

Western blot detection of BTK in Daudi,Jurkat(BTK negative),K562,Ramos and Raji cell lysates using BTK mouse mAb (1:1000 diluted).Predicted band size:77KDa.Observed band size:77KDa. Mouse IgG1 5B12-C9-F10 Purified WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

BTK antibody

Anti-BTK mouse monoclonal antibody (TA501102) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY BTK(RC211582). Mouse IgG2a OTI13E5 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

BTK antibody

BTK Luminex with 1H7 Capture (TA600509) and 12D4 Detection (TA700509) Antibodies. Substrate used: Recombinant Human BTK (TP311582) Mouse IgG1 OTI1H7 Purified Hu LMNX
0.1 mg / €325.00
  OriGene Technologies, Inc.

BTK antibody

BTK Luminex with 6H9 Capture (TA600510) and 12D4 Detection (TA700509) Antibodies. Substrate used: Recombinant Human BTK (TP311582) Mouse IgG1 OTI6H9 Purified Hu LMNX
0.1 mg / €325.00
  OriGene Technologies, Inc.

BTK antibody

BTK Luminex with 10E10 Capture (TA600511) and 6H9 Detection (TA700511) Antibodies. Substrate used: Recombinant Human BTK (TP311582) Mouse IgG1 OTI10E10 Purified Hu LMNX
0.1 mg / €325.00
  OriGene Technologies, Inc.

BTK antibody

BTK Luminex with 12D4 Capture (TA600512) and 10E10 Detection (TA700513) Antibodies. Substrate used: Recombinant Human BTK (TP311582) Mouse IgG1 OTI12D4 Purified Hu LMNX
0.1 mg / €325.00
  OriGene Technologies, Inc.

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