c-Myc antibody

Principal name

c-Myc antibody

Alternative names for c-Myc antibody

Transcription factor p64, BHLHE39, Myc proto-oncogene protein, Class E basic helix-loop-helix protein 39

SwissProt ID

P01106 (Human), P01108 (Mouse), P01109 (Chick), P09416 (Rat), Q28350 (Canfa), Q28566 (Sheep), Q29031 (Pig), Q2HJ27 (Bovin)

Gene ID

4609 (MYC)

Available reactivities

Hu (Human), Can (Canine), Ms (Mouse), Por (Porcine), Rb (Rabbit), Rt (Rat), Chk (Chicken), Bov (Bovine), Chimp (Chimpanzee), Fe (Feline), Bab (Baboon), Mky (Monkey), All Species, Av (Birds), Dros (Drosophila), Ye (Yeast), Bac (Bacteria), Mam (Mammalia), Gorilla, Sh (Sheep), Ze (Zebrafish)

Available hosts

Rabbit, Mouse, Chicken, Goat, Rat

Available applications

Frozen Sections (C), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Flow Cytometry (F), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Dot blot (Dot), ChIP assay (ChIP), ELISA (detection) (E(detection)), Luminex (LMNX)

Background of c-Myc antibody

MYC is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this MYC gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma.The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt\'s lymphomas, suggesting its importance in the normal function of this gene.The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt\'s lymphomas, suggesting its importance in the normal function of this gene.

General readings

1. Evan GI, Lewis GK, Ramsay G, Bishop JM. Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product. Mol Cell Biol. 1985 Dec;5(12):3610-6. PubMed PMID: 3915782.
2. Spandidos DA, Pintzas A, Kakkanas A, Yiagnisis M, Mahera H, Patra E, et al. Elevated expression of the myc gene in human benign and malignant breast lesions compared to normal tissue. Anticancer Res. 1987 Nov-Dec;7(6):1299-304. PubMed PMID: 3327455.
3. Borodina, I. et al. (2010) Display of wasp venom allergens on the cell surface of Saccharomyces cerevisiae. Microb. Cell Fact. 9: 74-86.
4. Groeger, G. et al. (2007) Co-operative Cdc42 and Rho signalling mediates ephrinB-triggered endothelial cell retraction. Biochem J. 404: 23-9.
5. Head, B. et al. (2009) Inducible proteolytic inactivation of OPA1 mediated by the OMA1 protease in mammalian cells. J Cell Biol. 187: 959-66.
6. Hilpert, K. et al. (2001) Anti-c-myc antibody 9E10: epitope key positions and variability characterized using peptide spot synthesis on cellulose. Protein Eng. 14: 803-6.
7. Krauss, N. et al. (2008) The structure of the anti-c-myc antibody 9E10 Fab fragment/epitope peptide complex reveals a novel binding mode dominated by the heavy chain hypervariable loops. Proteins. 73: 552-65.
8. Gray, P. et al. (2010) Identification of a novel human MD-2 splice variant that negatively regulates Lipopolysaccharide-induced TLR4 signaling. J Immunol. 184: 6359-66.
9. Duriseti, S. et al. (2010) Antagonistic anti-urokinase plasminogen activator receptor (uPAR) antibodies significantly inhibit uPAR-mediated cellular signaling and migration. J Biol Chem. 285: 26878-88.
10. Tan, P.H. et al. (2005) Creation of tolerogenic human dendritic cells via intracellular CTLA4: a novel strategy with potential in clinical immunosuppression. Blood. 106: 2936-43.
11. Wallace, S.W. et al. (2010) Cdc42 regulates apical junction formation in human bronchial epithelial cells through PAK4 and Par6B. Mol Biol Cell. 21: 2996-3006.
12. Rowshanravan, B. et al. (2014) RasGAP mediates neuronal survival in Drosophila through direct regulation of Rab5-dependent endocytosis. J Cell Sci. 127: 2849-61.
13. Taylor K et al. (2015) Nanocell targeting using engineered bispecific antibodies. MAbs. 7 (1): 53-65.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

c-Myc antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-MYC mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500002) Mouse IgG2b OTI1A6 Purified Hu F, ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

c-Myc antibody

Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-MYC mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500003) Mouse IgG2a OTI3F2 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

c-Myc antibody

Western Blot: c-Myc Antibody [TA336686] - Analysis of c-Myc on Jurkat whole cell extract using TA336686. Rabbit Purified Hu, Ms C, E, ICC/IF, IP, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

c-Myc antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-MYC mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500004) Mouse IgG2b OTI5G3 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

c-Myc antibody

Immunofluorescent staining of HeLa cells using anti-MYC mouse monoclonal antibody (TA507203). Mouse IgG2a OTI5E9G2 Purified Can, Hu, Mky, Rt ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

c-Myc antibody

Western blot analysis of MYC (arrow) using rabbit polyclonal MYC Antibody (T58) (Cat.#TA302042). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the MYC gene (Lane 2) (Origene Technologies). Rabbit Ig Aff - Purified Hu, Ms, Ze P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

c-Myc antibody

Western blot analysis of MYC (arrow) using rabbit polyclonal MYC Antibody (S62) (Cat.#TA302044). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the MYC gene (Lane 2) (Origene Technologies). Rabbit Ig Aff - Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

c-Myc antibody

Western blot analysis of MYC (arrow) using rabbit polyclonal MYC Antibody (S373) (Cat.#TA302045). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the MYC gene (Lane 2) (Origene Technologies). Rabbit Ig Aff - Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

c-Myc antibody

Sample (20 ug of whole cell lysate). A: human ESC. 10% SDS PAGE. TA307883 diluted at 1:1000. Rabbit IgG Aff - Purified Hu, Ms ChIP, F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

c-Myc antibody

Western blot analysis of MYC expression in Forskolin treated HeLa whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

c-Myc antibody

Western blot analysis of MYC expression in ovarycancer whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

c-Myc antibody

Western blot analysis of extracts from HuvEc cells, using MYC Antibody. The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

c-Myc antibody

Western blot analysis of extracts from HUVEC cells, using Myc antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

c-Myc antibody

Jurkat  extract was resolved by electrophoresis, transferred to nitrocellulose and probed with anti-c-myc monoclonal antibody. Proteins were visualized using a goat anti-mouse secondary conjugated to HRP and a chemiluminescence detection system. Intact (non-degraded) c-myc with a molecular weight of approximately 62 kD is detected in this Western blot experiment. Mouse IgG1 9E10 Purified Hu E, ICC/IF, IP, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

c-Myc antibody

Western Blot: c-Myc Antibody (9E11) [TA336584] - Analysis of c-Myc in Jurkat whole cell lysate. Mouse IgG2a 9E11 Purified Chk, Hu, Ms, Ye C, ChIP, E, F, IP, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

c-Myc antibody

Western Blot: c-Myc Antibody (9E10) [TA336685] - Analysis of c-myc in Jurkat cell lysates using TA336685. Mouse IgG1 9E10 Purified Dros, Hu, Ms C, E, F, ICC/IF, IP, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

c-Myc antibody

Western blot analysis on 293 cell lysate using MYC Antibody Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

c-Myc antibody

MYC ELISA with 3F2 Capture (TA600496) and 1A6 Detection (TA700496) Antibodies. Substrate used: Recombinant Human MYC (TP301611) Mouse IgG1 OTI3F2 Purified Hu E, LMNX
0.1 mg / €325.00
  OriGene Technologies, Inc.

c-Myc antibody

MYC ELISA with 1A6 Capture (TA600497) and 3F2 Detection (TA700497) Antibodies. Substrate used: Recombinant Human MYC (TP301611) Mouse IgG1 OTI1A6 Purified Hu E, LMNX
0.1 mg / €325.00
  OriGene Technologies, Inc.

c-Myc antibody

MYC ELISA with 3F2 Capture (TA600496) and 1A6 Detection (TA700496) Antibodies. Substrate used: Recombinant Human MYC (TP301611) Mouse IgG1 OTI1A6 Purified Hu E, LMNX
50 µg / €345.00
  OriGene Technologies, Inc.

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