C1q A subunit antibody

Principal name

C1q A subunit antibody

Alternative names for C1q A subunit antibody

Complement C1q, Complement 1q, Complement C1q subcomponent subunit A

SwissProt ID

P02745 (Human), P31720 (Rat), P98086 (Mouse), Q5E9E3 (Bovin), Q69DL0 (Pig)

Gene ID

712 (C1QA), 298566 (C1qa)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Sheep, Rabbit, Goat, Rat

Available applications

Enzyme Immunoassay (E), Functional assay (FN), Western blot / Immunoblot (WB), Frozen Sections (C), Immunodiffusion (ID), Flow Cytometry (F), ELISA (detection) (E(detection)), Radioimmunoassay (R), EPair for Elisa (EPair), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of C1q A subunit antibody

Clq, a member of the 'defense collagen' family, is the first subcomponent of the Cl complex of the classical pathway of complement activation. Several functions have been assigned to the pattern recognition molecule Clq, which include antibody-dependent and independent immune functions like triggering of rapid enhanced phagocytosis resulting in efficient containment of pathogens or clearance of cellular debris, apoptotic cells and immune complexes , and is considered to be mediated by Clq receptors present on the effector cell surface. There remains some uncertainty about the identities of the receptors that mediate Clq functions. Some of the previously described Clq receptor molecules, such as gClqR and cClqR, now appear to have less of a role in Clq functions than in functions unrelated to Clq. Experiments with gene targeted homozygous Clq-deficient mice have suggested a role for Clq in modulation of the humoral immune response, and also in protection against development of autoimmunity. The first component of complement Cl is a complex of three glycoproteins - Clq, Clr, and Cls. Cls and Clr interact to form a Cazf-dependent tetrameric proenzyme complex, C lr,-C 1 s2, which makes contacts with the Clq collagen domain. Binding of Clq to immune complexes (IgG or IgM) via the gClq domain, is considered to induce a conformational change in the collagen region of Clq, which leads to the autoactivation of Clr which, in turn, activates Cls. The activated Cl complex then cleaves components C4 and C2 in the classical complement cascade.

General readings

1. Nascimento EJ, Silva AM, Cordeiro MT, Brito CA, Gil LH, Braga-Neto U, et al. Alternative complement pathway deregulation is correlated with dengue severity. PLoS One. 2009 Aug 26;4(8):e6782. doi: 10.1371/journal.pone.0006782. PubMed PMID: 19707565.
2. Lewis MJ, Wagner B, Woof JM. The different effector function capabilities of the seven equine IgG subclasses have implications for vaccine strategies. Mol Immunol. 2008 Feb;45(3):818-27. Epub 2007 Jul 31. PubMed PMID: 17669496.
3. Jacobs BC, O'Hanlon GM, Bullens RW, Veitch J, Plomp JJ, Willison HJ. Immunoglobulins inhibit pathophysiological effects of anti-GQ1b-positive sera at motor nerve terminals through inhibition of antibody binding. Brain. 2003 Oct;126(Pt 10):2220-34. Epub 2003 Jul 22. PubMed PMID: 12876146.
4. Arduin E, Arora S, Bamert PR, Kuiper T, Popp S, Geisse S, et al. Highly reduced binding to high and low affinity mouse Fc gamma receptors by L234A/L235A and N297A Fc mutations engineered into mouse IgG2a. Mol Immunol. 2015 Feb;63(2):456-63. doi: 10.1016/j.molimm.2014.09.017. Epub 2014 Oct 18. PubMed PMID: 25451975.
5. Troedson C, Wong M, Dalby-Payne J, Wilson M, Dexter M, Rice GI, et al. Systemic lupus erythematosus due to C1q deficiency with progressive encephalopathy, intracranial calcification and acquired moyamoya cerebral vasculopathy. Lupus. 2013 May;22(6):639-43. doi: 10.1177/0961203313486950. Epub 2013 May 7. PubMed PMID: 23651859.
5. Kao Daniela et al. (2015) A Monosaccharide Residue Is Sufficient to Maintain Mouse and Human IgG Subclass Activity and Directs IgG Effector Functions to Cellular Fc Receptors Cell Reports.
6 Dec [Epub ahead of print]. 
6. Gearing, D.P. et al. (2016) In Vitro and In Vivo Characterization of a Fully Felinized Therapeutic Anti-Nerve Growth Factor Monoclonal Antibody for the Treatment of Pain in Cats. J Vet Intern Med. Jun 15. [Epub ahead of print].

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

C1q antibody

C1q Mouse IgG1 3R9/2 Purified Hu C, E, F
0.1 ml / €400.00
  Acris Antibodies GmbH

C1q antibody

C1q Goat IgG FITC Hu C, E, ICC/IF, ID, IP
1 ml / €350.00
  Acris Antibodies GmbH

C1q antibody

C1q Goat Serum Hu ID, IP
1 ml / €260.00
  Acris Antibodies GmbH

C1q antibody

C1q Rabbit Serum Hu ID, IP
1 ml / €260.00
  Acris Antibodies GmbH

C1q antibody

C1q Goat IgG Aff - Purified Hu E
1 mg / €500.00
  Acris Antibodies GmbH

C1q antibody

C1q Mouse IgG1 242G3 Purified Hu E, FN, WB
50 µg / €300.00
  Acris Antibodies GmbH

C1q antibody

C1q Sheep FITC Hu C
1 ml / €400.00
  Acris Antibodies GmbH

C1q antibody

C1q Sheep IgG HRP Hu E
1 ml / €380.00
  Acris Antibodies GmbH

C1q antibody

C1q Sheep Purified Hu ID
1 ml / €400.00
  Acris Antibodies GmbH

C1q A subunit antibody

  Rabbit Polyclonal Anti-C1QA Antibody  
WB Suggested Anti-C1QA Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: Hela cell lysate Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

C1q A subunit antibody

C1q A subunit Rat IgG1 7H8 Purified Ms C, E, FN, IP
0.1 mg / €420.00
  Acris Antibodies GmbH

C1q A subunit antibody

C1q A subunit Mouse IgG2b JL-1 Biotin Hu, Ms, Rt C, E, FN, ICC/IF, WB
50 µg / €340.00
  Acris Antibodies GmbH

C1q A subunit antibody

C1q A subunit Mouse IgG2b JL-1 FITC Hu, Ms, Rt C, E, FN, ICC/IF, WB
0.1 mg / €500.00
  Acris Antibodies GmbH

C1q A subunit antibody

C1q A subunit Mouse IgG2b JL-1 Purified Hu, Ms, Rt C, E, FN, ICC/IF, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

C1q A subunit antibody

C1QA MaxPab polyclonal antibody. Western Blot analysis of C1QA expression in human lung cancer. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

C1q A subunit antibody

C1QA MaxPab polyclonal antibody. Western Blot analysis of C1QA expression in human lung cancer. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

C1q A subunit antibody

Western Blot analysis of C1QA expression in transfected 293T cell line (H00000712-T02) by C1QA MaxPab polyclonal antibody.

Lane 1: C1QA transfected lysate(26.95 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

C1q A subunit antibody

Western Blot analysis of C1QA expression in transfected 293T cell line (H00000712-T03) by C1QA MaxPab polyclonal antibody.

Lane 1: C1QA transfected lysate(26.00 KDa).
Lane 2: Non-transfected lysate. Rabbit Serum Hu E(detection), IP, WB
0.1 ml / €380.00
  Abnova Taiwan Corp.

C1q A subunit antibody

C1QA MaxPab rabbit polyclonal antibody. Western Blot analysis of C1QA expression in human kidney. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

C1q A subunit antibody

C1q A subunit Mouse IgG2b 9A7 Hu, Ms, Rt E, WB
0.1 ml / €390.00
  Abnova Taiwan Corp.

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