C1QBP antibody

Principal name

C1QBP antibody

Alternative names for C1QBP antibody

GC1QBP, HABP1, SF2P32, GC1q-R protein, p33, p32, Complement component 1 Q subcomponent-binding protein, Glycoprotein gC1qBP, GC1q-R protein, Hyaluronan-binding protein 1, Mitochondrial matrix protein p32, p33

SwissProt ID

O35658 (Mouse), O35796 (Rat), Q07021 (Human), Q3T0B6 (Bovin)

Gene ID

708 (C1QBP), 29681 (C1qbp)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Hst (Hamster)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Immunoprecipitation (IP), Functional assay (FN)

Background of C1QBP antibody

The molecule is an unusually acidic, single chain protein with an apparent molecular weight of 33 kDa. It does not possess a conventional sequence motif compatible with a membrane spanning segment nor a consensus site for a GPI anchor. gC1q-R migrates as a single chain under both reducing and non-reducing conditions, but it behaves as an oligomer on gel-filtration in non-dissociating conditions. Its multimer formation may be a critical process by which the gC1q-R molecule increases its affinity for multivalent ligands such as C1q.
gC1q-R has been shown to inhibit complement activation by preventing the binding of C1q to antibodies, suggesting that the binding site for gC1q-R and the binding site for immune complexes, which are present on the C1q globular ‘heads’, may be located at the same position. gC1q-R is capable of interacting with several proteins involved in blood clotting, namely, thrombin, prothrombin, the heparinbinding form of vitronectin, the ternary complex, vitronectin-thrombin-antithrombin, as well as high-molecular-weight kininogen and Hageman factor. Besides its role in the complement pathway, gC1q-R participates in enhancement of Fc-receptor and CR1-mediated phagocytosis, procoagulant activity on platelets, and chemotactic activity on mast cells, eosinophils, neutrophils, and fibroblasts.
gC1q-R is expressed on a wide variety of cells and can serve as a binding site for plasma and microbial proteins. Its antigenic sites may be cryptic on cells in suspension but become exposed when the cells are fixed by bifunctional cross-linkers. Probably it is also expressed on the cell membrane as a tetramer. Crosslinking or activation may thus bring about a tetrameric assembly of gC1q-R followed by a conformational change within the molecule, thereby exposing epitopes which are otherwise hidden. A form of GC1q-R is also found inside the cell. Intracellular gC1q-R has been shown to bind the cytoplasmic tail of the α1B-adrenergic receptor and to PKCµ.

General readings

Deb TB, et al. (1996) J Biol Chem 271(4):2206-12. Ghebrehiwet B, et al. (1994) J Exp Med 179(6):1809-21.Entrez Gene: C1QBP complement component 1, q subcomponent binding protein.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

C1QBP antibody

  C1QBP Rabbit Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using C1QBP antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

C1QBP antibody

  Rabbit polyclonal anti-C1QBP antibody  
Western blot analysis of extracts from Jurkat cells, K562 cells and HUVEC cells, using C1QBP antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

C1QBP antibody

C1QBP Mouse IgG1 74.5.2 Purified Hu, Rt E, FN, ICC/IF, IP, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

C1QBP (76-93) antibody

C1QBP Mouse IgG1 60.11 FITC Hst, Hu, Rt E, FN, IP, WB
0.1 mg / €400.00
  Acris Antibodies GmbH

C1QBP (76-93) antibody

C1QBP Mouse IgG1 60.11 Purified Hst, Hu, Rt E, FN, IP, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

C1QBP antibody

The recombinant protein(50ng) and cell lysates(40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human C1QBP antibody (1:2000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.

Lane 1 : Recombinant protein 
Lane 2 : HeLa cell lysate 
Lane 3 : Jurkat cell lysate 
Lane 4 : MCF7 cell lysate 
Lane 5 : Ramos cell lysate 
Lane 6 : 293T cell lysate
Lane 7 : A549 cell lysate Mouse IgG1 AT1G7 Purified Hu E, WB
0.1 ml / €310.00
  Acris Antibodies GmbH

C1QBP antibody

The recombinant protein(50ng) and cell lysates(40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human C1QBP antibody (1:2000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.

Lane 1 : Recombinant protein 
Lane 2 : HeLa cell lysate 
Lane 3 : Jurkat cell lysate 
Lane 4 : MCF7 cell lysate 
Lane 5 : Ramos cell lysate 
Lane 6 : 293T cell lysate
Lane 7 : A549 cell lysate Mouse IgG1 AT1G7 Purified Hu E, WB
50 µl / €220.00
  Acris Antibodies GmbH

C1QBP (C-term) antibody

Western blot analysis of anti-C1QBP Antibody (C-term) in 293 cell line lysates (35ug/lane). C1QBP(arrow) was detected using the purified Pab (1:60 dilution). Rabbit Ig Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

C1QBP antibody

Western blot analysis of anti-C1QBP Antibody (Center) in HepG2 cell line lysates (35ug/lane).C1QBP(arrow) was detected using the purified Pab (1:60dilution). Rabbit Ig Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

C1QBP antibody

Western blot (WB) analysis of C1QBP antibody (Cat.-No.: AP21154PU-N) in extracts from Jurkat cells. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 mg / €350.00
  Acris Antibodies GmbH

C1QBP antibody

Immunohistochemistry analysis of paraffin-embedded human tonsil tissue, using C1QBP Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €230.00
  Assay Biotech

C1QBP antibody

Immunohistochemistry analysis of paraffin-embedded human tonsil tissue, using C1QBP Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €330.00
  Assay Biotech

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

C1QBP (74-282)

Western blot analysis of anti-C1QBP Antibody (C-term) in 293 cell line lysates (35ug/lane). C1QBP(arrow) was detected using the purified Pab (1:60 dilution). Human Purified > 95 % > 95% by SDS PAGE E. coli
0.5 mg / €690.00
  Acris Antibodies GmbH

C1QBP (74-282)

Western blot analysis of anti-C1QBP Antibody (C-term) in 293 cell line lysates (35ug/lane). C1QBP(arrow) was detected using the purified Pab (1:60 dilution). Human Purified > 95 % > 95% by SDS PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, C1qbp (GFP-tagged ORF) - Rat complement component 1, q subcomponent binding protein (C1qbp), nuclear gene encoding mitochondrial protein, 200 uL, >10^7 TU/mL

Lenti ORF particles, C1qbp (GFP-tagged ORF) - Rat complement component 1, q subcomponent binding protein (C1qbp), nuclear gene encoding mitochondrial protein, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, C1qbp (Myc-DDK-tagged ORF) - Rat complement component 1, q subcomponent binding protein (C1qbp), nuclear gene encoding mitochondrial protein, 200 uL, >10^7 TU/mL

Lenti ORF particles, C1qbp (Myc-DDK-tagged ORF) - Rat complement component 1, q subcomponent binding protein (C1qbp), nuclear gene encoding mitochondrial protein, 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

16 Item(s)

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