C3a Receptor antibody

Principal name

C3a Receptor antibody

Alternative names for C3a Receptor antibody

C3a-R, C3AR, C3AR1, AZ3B, C3R1, HNFAG09, C3a anaphylatoxin chemotactic receptor

SwissProt ID

O09047 (Mouse), O55197 (Rat), Q16581 (Human)

Gene ID

12267 (C3ar1), 719 (C3AR1), 100171925 (YWHAQ), 84007

Available reactivities

Ms (Mouse), Rt (Rat), Hu (Human), Eq (Equine), Hst (Hamster), Mky (Monkey)

Available hosts

Chicken, Rabbit, Mouse

Available applications

Paraffin Sections (P), Enzyme Immunoassay (E), Frozen Sections (C), Flow Cytometry (F), ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of C3a Receptor antibody

The inte immune system identifies pathogens by recognizing known elements. This response ultimately leads to the production of proinflammatory substances and the activation of phagocytic neutrophils and macrophages. Activation of the complement system is an important initial even in the response against pathogens. This system includes some thirty different proteins that act together to form a complex. Three different pathways are known to activate the complement. The C3 complement plays a key role in all three pathways leading to the activation of the complement. Produced in the liver, C3 is the most abundant complement protein in the serum. It is composed of two polypeptides, an α and β chain. Cleavage of C3 leads to the production of C3b and C3a. C3a binds to C3a receptor, a G-protein coupled receptor which couples to Gi upon activation. Like all other members of the superfamily, C3a receptor has seven transmembrane domains with an extracellular N-terminus and intracellular C-termil tail. The receptor has two glycosylation sites, an unusually large extracellular loop with a sulfated tyrosine residue important for ligand recognition and binding. C3a receptor is expressed in cells of myeloid origin like neutrophils, macrophages and dendritic cells to me a few. It is also detected in astrocytes from inflamed brain, endothelial cells and activated human T cells. mR of C3a receptor is detected in lung, liver, kidney, brain heart, muscle and testis.

General readings

1. Luhmann, A.E. et al. Immunohistochemical analysis of human and rat C3a receptor expression by the use of monoclonal antibodies. Molecular Immunology (Abstracts), 2001., 38:108.
2. Fukuoka, Y., et al. Cloning and characterization of rat C3a receptor: differential expression of rat C3a and C5a receptors by LPS stimulation. Biochem. And Biophys. Res. Comm. 1998, 242: 663.
3. Francis, K., et al. Complement C3a receptors in the pituitary gland: a novel pathway by which an innate immune molecule releases hormones involved in the control of inflammation. The FASEB journal. 2003, 17: 2266.
4. Benard, M., et al. Characterization of C3a and C5a receptors in rat cerebellar granule neurons during
maturation. J. Biol. Chem. 2004, 279 (42): 43487.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

C3a Receptor antibody

Western blot analysis of differentiated HL-60 cell lysate: 1. Anti-C3a Anaphylatoxin Receptor (extracellular) antibody, (1:200). 2. Anti-C3a Anaphylatoxin Receptor (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

C3a Receptor antibody

Anti-C3AR / C3a Receptor antibody IHC of human lung, respiratory epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1.25 ug/ml. Rabbit Purified Eq, Hst, Hu, Mky, Ms
50 µg / €379.00
  OriGene Technologies, Inc.

C3a Receptor antibody

Anti-C3AR / C3a Receptor antibody IHC of human lung, respiratory epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 17.3 ug/ml. Rabbit Purified Hu, Mky
50 µg / €379.00
  OriGene Technologies, Inc.

C3a Receptor antibody

C3a Receptor Mouse IgG1 hC3aRZ1 Purified Hu C, F
0.2 mg / €450.00
  Acris Antibodies GmbH

C3a Receptor antibody

C3a Receptor Mouse IgG1 hC3aRZ1 Purified Hu C, F
0.1 mg / €290.00
  Acris Antibodies GmbH

C3a Receptor antibody

C3a Receptor Mouse IgG1 hC3aRZ1 Purified Hu C, F
25 µg / €180.00
  Acris Antibodies GmbH

C3a Receptor antibody

C3a Receptor Mouse IgG1 hC3aRZ1 PE Hu F
100 Tests / €490.00
  Acris Antibodies GmbH

C3a Receptor antibody

C3a Receptor Mouse IgG2b 17 FITC Hu C
0.1 mg / €490.00
  Acris Antibodies GmbH

C3a Receptor antibody

C3a Receptor Mouse IgG2b 17 Purified Hu C
0.1 mg / €490.00
  Acris Antibodies GmbH

C3a Receptor antibody

C3a Receptor Mouse IgG1 74 Biotin Rt C, F
0.1 mg / €290.00
  Acris Antibodies GmbH

C3a Receptor antibody

Cell Source: Peritoneal Macrophages
Percentage of cells stained above control: 97.2% Mouse IgG1 74 FITC Rt C, F
0.1 mg / €290.00
  Acris Antibodies GmbH

C3a Receptor antibody

C3a Receptor Mouse IgG1 74 Purified Rt C, F
0.25 mg / €290.00
  Acris Antibodies GmbH

C3a Receptor antibody

C3a Receptor Mouse IgG1 74 PE Rt C, F
50 µg / €290.00
  Acris Antibodies GmbH

C3a Receptor antibody

Mouse Brain, Paraffin Section stained with C3a Receptor Antibody Cat.-No BP4002 Chicken Aff - Purified Ms, Rt C, E, P
0.1 mg / €390.00
  Acris Antibodies GmbH

C3a Receptor antibody

C3AR1 MaxPab polyclonal antibody. Western Blot analysis of C3AR1 expression in K-562. Mouse Serum Hu E(detection), F, WB
50 µl / €370.00
  Abnova Taiwan Corp.

C3a Receptor antibody

C3AR1 MaxPab polyclonal antibody. Western Blot analysis of C3AR1 expression in K-562. Mouse Purified Hu E(detection), F, WB
50 µg / €370.00
  Abnova Taiwan Corp.

C3a Receptor antibody

C3AR1 MaxPab rabbit polyclonal antibody. Western Blot analysis of C3AR1 expression in human liver. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

C3a Receptor antibody

C3a Receptor Rabbit Hu F
0.1 mg / €470.00
  Abnova Taiwan Corp.

C3a Receptor antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using C3AR1 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF, P
50 µg / €205.00
  Assay Biotech

C3a Receptor antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using C3AR1 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF, P
0.1 mg / €310.00
  Assay Biotech

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