CAB39 antibody

Principal name

CAB39 antibody

Alternative names for CAB39 antibody

Calcium-binding protein 39, MO25, CGI-66

SwissProt ID

Q06138 (Mouse), Q29RI6 (Bovin), Q9Y376 (Human)

Gene ID

51719 (CAB39)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit), Ze (Zebrafish)

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of CAB39 antibody

Calcium Binding Protein 39 (CAB39) is a scaffolding protein, located at human chromosome 2q37.1 (1). In conjugation with psuedokinase STE20-Related Adaptor protein (STRAD), it regulates the activity of Serine/Threonine Kinase 11 (STK11/LKB1) tumor suppressors (2). LKB1 was discovered in 1988 and ever since then extensive research has been conducted in understanding how this protein might be regulated. It was reported that LKB1 mediates its cellular functions through interactions with a number of proteins including CAB39 and STRADalpha (3). CAB39 and STRADalpha are key proteins required for the growth suppressive function of LKB1 (4). Located on opposite surfaces of CAB39 are two binding sites that are required for it to form a complex with STRADalpha and LKB1. It was reported CAB39 plays a key role in increasing the catalytic activity of LKB1 towards its substrates (5).
Studies have shown that CAB39 along with ATP maintains STRADalpha in an “active” closed conformation which promotes LKB1 activation and its relocalization from the nucleus to the cytoplasm and this leads to a 10-fold increase in catalytic activity of LKB1 towards its substrates (5). CAB39 also enhances and stabilizes the formation of LKB1-STRADalpha complex by binding to a conserved Tri-Glu-Phe sequence at the C terminus of STRADalpha. This also stimulates the catalytic activity of LKB1 (6). CAB39 by itself is expressed in nucleus and cytoplasm. CAB39 is approximately a 40 kDa protein (341 amino acids).

General readings

Baas AF., et al. (2004) Trends Cell Biol. 14(6):312-9.
Boudeau J., et al. (2003) EMBO J. 22(19):5102-14.

17 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CAB39 antibody

WB Suggested Anti-CAB39 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: Human Liver Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

CAB39 Control Peptide

CAB39
0.25 mg / €250.00
  Acris Antibodies GmbH

CAB39 antibody

CAB39 Rabbit Aff - Purified Ms E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

CAB39 antibody

Western Blot analysis of CAB39 expression in transfected 293T cell line (H00051719-T01) by CAB39 MaxPab polyclonal antibody.

Lane 1: CAB39 transfected lysate(37.51 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

CAB39 antibody

Proximity Ligation Analysis (PLA) of protein-protein interactions between STK11 and CAB39 HeLa cells were stained with anti-STK11 rabbit purified polyclonal 1:1200 and anti-CAB39 mouse purified polyclonal antibody 1:50. Signals were detected by Duolink® 30 Detection Kit 613(red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

CAB39 antibody

Western Blot analysis of CAB39 expression in transfected 293T cell line (H00051719-T02) by CAB39 MaxPab polyclonal antibody.

Lane 1: CAB39 transfected lysate(39.90 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

CAB39 antibody

Human Liver; WB Suggested Anti-CAB39 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: Human Liver; CAB39 antibody - middle region (ARP56877_P050) in Human Liver cells using Western Blot Rabbit Aff - Purified Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

CAB39 antibody

Western Blot: CAB39 Antibody [NBP1-55393] - This Anti-CAB39 antibody was used in Western Blot of Fetal Liver tissue lysate at a concentration of 1ug/ml. Rabbit Aff - Purified Hu, Ms, Rt WB
50 µg / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CAB39 (transcript variant 1)

CAB39 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

CAB39 (transcript variant 2)

CAB39 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

CAB39 (transcript variant 3)

CAB39 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

CAB39 (1-341, His-tag)

CAB39 Human Purified > 90 % by SDS - PAGE E. coli
0.25 mg / €1,000.00
  Acris Antibodies GmbH

CAB39 (1-341, His-tag)

CAB39 Human Purified > 90 % by SDS - PAGE E. coli
50 µg / €370.00
  Acris Antibodies GmbH

CAB39

CAB39 Human
50 µg / €450.00
  Abnova Taiwan Corp.

CAB39

CAB39 Human Purified
0.25 mg / €1,140.00
  Novus Biologicals Inc.

CAB39

CAB39 Human Purified
50 µg / €440.00
  Novus Biologicals Inc.

Lysates

Catalog No.    

CAB39 293T Cell Transient Overexpression Lysate(Denatured)

CAB39 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

17 Item(s)

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