CABLES2 antibody

Principal name

CABLES2 antibody

Alternative names for CABLES2 antibody

C20orf150, Ik3-2, CDK5 and ABL1 enzyme substrate 2, Interactor with CDK3 2

SwissProt ID

Q8K3M5 (Mouse), Q9BTV7 (Human)

Gene ID

81928 (CABLES2)

Available reactivities

Hu (Human), Ms (Mouse)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of CABLES2 antibody

Cables2 (Cdk5 and ABL1 enzyme substrate 2), also known as Ik3-2, is a 478 amino acid ubiquitously expressed protein that has a C-terminal cyclin box-containing domain, making it a member of the cyclin protein superfamily. A related protein, Cables, forms a trimolecular complex with Cdk5 and c-Abl in vivo, enhances apoptosis induced by overexpression of p53 and may be a tumor suppressor, due to its chromosomal loss of heterozygosity that is found in certain cancers. Cables2 shares 78% sequence similarity with Cables in the region of the cyclin box-containing domain and, in similar functionality, associates with Cdk3, Cdk5 and c-Abl. However, unlike its close relative, Cables2 also contains an N-terminal region that enhances not only p53-mediated cell death, but also p53-independent cell death. This characteristic suggests that the gene encoding Cables2 may also function as a tumor suppressor gene.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CABLES2 antibody

  Rabbit polyclonal anti-CABLES2 (Ik3-2) antibody  
Western blot analysis of extracts from Jurkat cells, using Ik3-2 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CABLES2 antibody

  Rabbit polyclonal CABLES2 Antibody (Center)  
CABLES2 Antibody (Center) (Cat. #TA325162) western blot analysis in PC-3 cell line and mouse brain,testis and liver lysates (35ug/lane).This demonstrates the CABLES2 antibody detected the CABLES2 protein (arrow). Rabbit IgG Purified Hu, Ms WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

CABLES2 antibody

  Rabbit Polyclonal Anti-CABLES2 Antibody  
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using (CABLES2 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200) Rabbit IgG Purified Hu, Ms E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CABLES2 antibody

Immunofluorescence analysis of A549 cells, using Ik3-2 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, ICC/IF, WB
50 µg / €230.00
  Assay Biotech

CABLES2 antibody

Immunofluorescence analysis of A549 cells, using Ik3-2 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, ICC/IF, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

CABLES2 - human gene knockout kit via CRISPR

CABLES2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

CABLES2 - human gene knockout kit via CRISPR

CABLES2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

CABLES2 - human gene knockout kit via CRISPR

CABLES2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

CABLES2 - human gene knockout kit via CRISPR

CABLES2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, CABLES2 (mGFP-tagged)-Human Cdk5 and Abl enzyme substrate 2 (CABLES2), 200 uL, >10^7 TU/mL

Lenti ORF particles, CABLES2 (mGFP-tagged)-Human Cdk5 and Abl enzyme substrate 2 (CABLES2), 200 uL, >10^7 TU/mL  
200 µl / €1,100.00
  OriGene Technologies, Inc.

Lenti ORF particles, CABLES2 (Myc-DDK-tagged)-Human Cdk5 and Abl enzyme substrate 2 (CABLES2), 200 uL, >10^7 TU/mL

Lenti ORF particles, CABLES2 (Myc-DDK-tagged)-Human Cdk5 and Abl enzyme substrate 2 (CABLES2), 200 uL, >10^7 TU/mL  
200 µl / €980.00
  OriGene Technologies, Inc.

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