CACNA1B antibody

Principal name

CACNA1B antibody

Alternative names for CACNA1B antibody

CACH5, CACNL1A5, Cav2.2, Brain calcium channel III, Voltage-dependent N-type calcium channel subunit alpha-1B, Voltage-gated calcium channel subunit alpha, Calcium channel L type alpha-1 polypeptide isoform 5

SwissProt ID

O55017 (Mouse), O73706 (Chick), Q00975 (Human), Q02294 (Rat)

Gene ID

774 (CACNA1B), 12287 (Cacna1b), 257648

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of CACNA1B antibody

Voltage dependent Ca2+ channels (CaV channels) are pivotal players in many physiological roles such as secretion, contraction, migration and excitation.The voltage dependent Ca2+ channels are composed of several subunits; a1, Ã?, a2d and ?. CaV channels were origilly divided into six physiological types: L, N, P, Q, R, and T type.The CaV2.2 (formally med a1B) composes the a1 poreforming subunit for the N type Ca2+ channel family. They are involved in neurotransmitter release from central neurons, including glutamate, ?-aminobutyric acid, acetylcholine, dopamine and noradreline.The CaV2.2 is expressed preferentially in the central nervous system, where along with CaV2.1, it is responsible for pre-syptic Ca2+ influx and neurotransmitter release.The CaV2.2 channel is negatively regulated by many different GPCRs. There are two ways that this is done: either by directly binding GÃ?? to the channel or by an indirect mechanism involving second messenger and channel phosphorylation.?-Conotoxin GVIA is a specific blocker of Cav2.2 Ca2+ channels. It specifically blocks N-type Cav channels by binding to the Cav2.2 a1 subunit (a1B) and its action is only partially reversible.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CACNA1B antibody

CACNA1B antibody [C3], C-term detects CACNA1B protein by Western blot analysis. A. 30 ug U87-MG whole cell lysate/extract. 5 % SDS-PAGE. CACNA1B antibody [C3], C-term (TA308673) dilution: 1:500 Rabbit IgG Aff - Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CACNA1B antibody

Western blot analysis of rat brain membranes: 1. Anti-CaV2.2 antibody, (1:200). 2. Anti-CaV2.2 antibody, preincubated with the control antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

CACNA1B antibody

CACNA1B Rabbit IgG Purified Hu WB
0.1 mg / €370.00
  Acris Antibodies GmbH

CACNA1B (alpha-1) antibody

CACNA1B Rabbit Purified Hu C, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

CACNA1B antibody

CACNA1B Rabbit Hu, Ms, Rt E, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

CACNA1B antibody

CACNA1B Rabbit Hu, Ms, Rt WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

CRISPR

Catalog No. Species Donor Vector  

CACNA1B - human gene knockout kit via CRISPR

CACNA1B - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cacna1b - mouse gene knockout kit via CRISPR

Cacna1b - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Cacna1b - mouse gene knockout kit via CRISPR

Cacna1b - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cacna1b - mouse gene knockout kit via CRISPR

Cacna1b - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cacna1b - mouse gene knockout kit via CRISPR

Cacna1b - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

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