CACNA1C antibody

Principal name

CACNA1C antibody

Alternative names for CACNA1C antibody

CACH2, CACN2, CACNL1A1, CCHL1A1, Cav1.2, Voltage-dependent L-type calcium channel subunit alpha-1C, Voltage-gated calcium channel subunit alpha, Calcium channel L type alpha-1 polypeptide isoform 1 cardiac muscle

SwissProt ID

P15381, P22002 (Rat), Q01815 (Mouse), Q13936 (Human)

Gene ID

775 (CACNA1C), 100101555 (CACB), 24239 (Cacna1c), 12288

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse), Rb (Rabbit), Mky (Monkey)

Available hosts

Mouse, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of CACNA1C antibody

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on an ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligand- gated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2).
Specifially, Cav1.2 is a cardiac L-type calcium channel, and is important for excitation and contraction of the heart (3). It may be associated with a variant of Long QT syndrome called Timothy's syndrome (4, 5) and also with Brugada syndrome. Some references also suggest it is related to bipolar disease as well (5).

General readings

Saud ZA, Minobe E, Wang WY, Han DY, Horiuchi M, Hao LY, Kameyama M.
Calpastatin binds to a calmodulin-binding site of cardiac Cav1.2 Ca2+ channels.
Biochem Biophys Res Commun. 2007 Dec 14;364(2):372-7. Epub 2007 Oct 15.
PMID: 17950697

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CACNA1C (C-term) antibody

  Goat Anti-CACNA1C Antibody  
TA305878 (0.5ug/ml) staining of Human Heart lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CACNA1C antibody

  Mouse Monoclonal anti-CACNA1C Antibody  
IHC analysis of Cav1.2 in human hippocampus tissues. Mouse IgG2b S57-46 Purified Hu, Ms, Rt C, ICC/IF, IP, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CACNA1C antibody

  Rabbit Polyclonal Anti-human CaV1.2  
Western blot analysis of rat heart membranes: 1. Anti-Human-Cav1.2 antibody, (1:200). 2. Anti-Human-Cav1.2 antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

CACNA1C antibody

  Rabbit Polyclonal Anti-CaV1.2  
Western blot analysis of rat brain membranes: 1. Anti-CaV1.2 antibody, (1:200). 2. Anti-CaV1.2 antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

CACNA1C antibody

  Rabbit Polyclonal Anti-CaVpan alpha1  
Western blot analysis of rat brain membranes: 1. Anti-Cavpan a1 antibody, (1:200). 2. Anti-Cavpan a1 antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

CACNA1C antibody

  Rabbit Polyclonal Anti-CACNA1C Antibody (Internal)  
Anti-CACNA1C / Cav1.2 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu, Mky
50 µg / €400.00
  OriGene Technologies, Inc.

CACNA1C antibody

  Rabbit Polyclonal Anti-CACNA1C Antibody (C-Terminus)  
Anti-CACNA1C / Cav1.2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu, Mky
50 µg / €400.00
  OriGene Technologies, Inc.

CACNA1C antibody

  Rabbit Polyclonal Anti-CACNA1C Antibody  
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using (CACNA1C Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200) Rabbit IgG Purified Hu E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CACNA1C antibody

Adult rat hippocampus immunohistochemistry Mouse IgG2b L57/46 Supernatant Hu, Ms, Rt C, IP, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

CACNA1C antibody

Tissue and transfected cell immunoblot: extracts of rat brain membrane (RBM) and COS cells transiently transfected with untagged Cav1.2, Cav1.3 or Kv2.1 plasmids and probed with N263/31 (left) and L57/46 (right) TC supe. Mouse IgG2b N263/31 Supernatant Hu, Ms, Rt C, ICC/IF, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

CACNA1C antibody

Adult rat hippocampus immunohistochemistry Mouse IgG2b L57/46 Purified Hu, Ms, Rt C, IP, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

CACNA1C antibody

Tissue and transfected cell immunoblot: extracts of rat brain membrane (RBM) and COS cells transiently transfected with untagged Cav1.2, Cav1.3 or Kv2.1 plasmids and probed with N263/31 (left) and L57/46 (right) TC supe. Mouse IgG2b N263/31 Purified Hu, Ms, Rt C, ICC/IF, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

CACNA1C antibody

CACNA1C Rabbit Purified Hu C, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

CACNA1C pSer1928 antibody

CACNA1C Rabbit Serum Hu E, IP, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

CACNA1C (1507-1733) antibody

Cav1.2 Ca2+ channel staining of adult rat hippocampus Mouse IgG2b Supernatant Hu, Ms, Rt C, ICC/IF, WB
0.1 ml / €440.00
  Neuromics Antibodies

CRISPR

Catalog No. Species Donor Vector  

CACNA1C - human gene knockout kit via CRISPR

CACNA1C - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

CACNA1C - human gene knockout kit via CRISPR

CACNA1C - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

CACNA1C - human gene knockout kit via CRISPR

CACNA1C - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

CACNA1C - human gene knockout kit via CRISPR

CACNA1C - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cacna1c - mouse gene knockout kit via CRISPR

Cacna1c - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

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