CACNA1D antibody

Principal name

CACNA1D antibody

Alternative names for CACNA1D antibody

CACH3, CACN4, CACNL1A2, CCHL1A2, Cav1.3, Voltage-dependent L-type calcium channel subunit alpha-1D, Voltage-gated calcium channel subunit alpha, Calcium channel, L type, alpha-1 polypeptide, isoform 2

SwissProt ID

P27732 (Rat), Q01668 (Human), Q99246 (Mouse)

Gene ID

776 (CACNA1D), 29716 (Cacna1d)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Frozen Sections (C), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of CACNA1D antibody

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces.
There are a few main classifications of gated ion channels.
There are voltage- gated ion channels, ligand- gated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels.
Specifically, Cav1.3, also known as the calcium channel, voltage-dependent, L type, alpha 1D subunit (CACNA1D), is a human gene. Cav1.3 subunits are primarily expressed in neurons and neuroendocine cells. Some studies suggest however that Cav1.3 is also found in the atria, and may figure prominently in atrial arrhythmias (3).
Cav1.3 also carries the primary sensory receptors of the mammalian cochlea, and are also expressed in the electromotile outer hair cells (4).

10 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CACNA1D antibody

IF detection of Cav1.3 using Anti-Cav1.3 monoclonantibody (TA309307) on human hippocampal tissues. Mouse IgG2b S48A-9 Purified Hu, Ms, Rt C, ICC/IF, IP, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CACNA1D antibody

Immunohistochemical detection of Cav1.3 in frozen mouse brain sections using TA326516. Mouse IgG1 S38-8 Purified Hu, Ms, Rt ICC/IF, IP, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CACNA1D antibody

Western blot analysis of rat brain membranes: 1. Anti-Cav1.3 antibody, (1:200). 2. Anti-Cav1.3 antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

CACNA1D antibody

Western blot analysis of rat brain (lanes 1 and 4), mouse brain (lanes 2 and 5) and C6 (lanes 3 and 6) lysates: 1-3. Anti-Cav1.3 (extracellular) antibody, (1:200). 4-6. Anti-Cav1.3 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

CACNA1D antibody

Adult rat brain membrane immunoblot Mouse IgG1 N38/8 Supernatant Hu, Ms, Rt ICC/IF, IP, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

CACNA1D antibody

Adult rat brain membrane immunoblot. Mouse IgG2a L48A/9 Supernatant Hu, Ms, Rt C, ICC/IF, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

CACNA1D antibody

Adult rat brain membrane immunoblot Mouse IgG1 N38/8 Purified Hu, Ms, Rt ICC/IF, IP, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

CACNA1D antibody

Adult rat brain membrane immunoblot. Mouse IgG2a L48A/9 Purified Hu, Ms, Rt C, ICC/IF, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

CACNA1D (859-875) antibody

Cav1.3 Ca2+ channel staining of adult rat hippocampus. Mouse IgG2a Supernatant Hu, Ms, Rt C, IP, WB
0.1 ml / €440.00
  Neuromics Antibodies

CACNA1D antibody

CACNA1D Rabbit Serum Hu, Ms, Rt C, P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

10 Item(s)

per page
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