CACNA1S antibody

Principal name

CACNA1S antibody

Alternative names for CACNA1S antibody

CACH1, CACN1, CACNL1A3, Cav1.1, Voltage-dependent L-type calcium channel subunit alpha-1S, Voltage-gated calcium channel subunit alpha Cav1.1, Calcium channel L type alpha-1 polypeptide isoform 3 skeletal muscle

SwissProt ID

Q02485 (Rat), Q02789 (Mouse), Q13698 (Human)

Gene ID

779 (CACNA1S)

Available reactivities

Hu (Human), GP (Guinea Pig), Ms (Mouse), Rb (Rabbit), Rt (Rat), Fe (Feline)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Immunoprecipitation (IP), Flow Cytometry (F)

Background of CACNA1S antibody

Voltage-sensitive calcium channels mediate the entry of calcium into many types of excitable cells and thus play a key role in neurotransmitter release and excitation-contraction (E-C) coupling. The 1,4-dihydropyridines (DHPs) are synthetic organic compounds which can be used to identify the L-type calcium channels that are found in all types of vertebrate muscle, neuronal and neuroendocrine cells. The DHP receptor is part of the L-type calcium channel complex and is thought to be the voltage sensor in E-C coupling.The purified DHP receptor isolated from triads is composed of at least four subunits. The alpha-1 subunit contains the binding site for the DHPs and shows high sequence homology to the voltage gated sodium channel. The alpha-2 subunit is a large glycoprotein associated with the DHP receptor which was first described in skeletal muscle and is also found in high concentrations in other excitable tissues such as cardiac muscle and brain and in low concentrations in most other tissues studied. The other two subunits that co-purify with the DHP receptor are termed beta and gamma.

General readings

This product has been used in:Morton ME & Froehner SC The alpha 1 and alpha 2 polypeptides of the dihydropyridine-sensitive calcium channel differ in developmental expression and tissue distribution. Neuron 2:1499-506 (1989). PubMed PMID: 2560646
General / background references:Protasi F et al. Role of ryanodine receptors in the assembly of calcium release units in skeletal muscle. J Cell Biol 140:831-42 (1998). PubMed PMID: 9472035
Flucher BE et al. Localization of the alpha 1 and alpha 2 subunits of the dihydropyridine receptor and ankyrin in skeletal muscle triads. Neuron 5:339-51 (1990). PubMed PMID: 2169270

9 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CACNA1S antibody

Sample (30 ug of whole cell lysate). A: 293T. 5% SDS PAGE. TA308209 diluted at 1:1000. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CACNA1S (alpha-1) antibody

CACNA1S Rabbit Serum Hu C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

CACNA1S antibody

CACNA1S Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

CACNA1S antibody

Detection limit for recombinant GST tagged CACNA1S is approximately 0.3ng/ml as a capture antibody. Mouse IgG2a 2C5 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

CACNA1S antibody

CACNA1S Mouse IgG2a 20A Ascites GP, Hu, Ms, Rb, Rt C, ICC/IF, IP, P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

CACNA1S antibody

CACNA1S Antibody [NBP1-31659] - Immunohistochemical analysis of paraffin-embedded Cal27 xenograft , using CACNA1S antibody at 1:100 dilution. Rabbit IgG Hu P, WB
0.1 ml / €420.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CACNA1S

CACNA1S Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

CACNA1S

CACNA1S Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

CACNA1S overexpression lysate

CACNA1S overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

9 Item(s)

per page
  • LinkedIn