CACNA2D2 antibody

Principal name

CACNA2D2 antibody

Alternative names for CACNA2D2 antibody

KIAA0558, Voltage-dependent calcium channel subunit alpha-2/delta-2

SwissProt ID

Q6PHS9 (Mouse), Q8CFG6 (Rat), Q9NY47 (Human)

Gene ID

9254 (CACNA2D2), 300992 (Cacna2d2), 56808

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse), Bov (Bovine), Can (Canine), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of CACNA2D2 antibody

Voltage-gated Ca2+ channels (CaV), eble the passage of Ca2+ ions in a voltage dependent manner. These heteromeric entities are formed in part by the pore-forming a1 subunit which determines the biophysical and pharmacological properties of the channel.CaV1 and CaV2 channels are high-voltage activated (HVA) CaV channels. The a1 subunit of these channels normally interacts and associates with a2d subunit, a membrane anchored protein and CaVÃ?, a cytosolic protein.Four a2d subunits have been cloned to date: a2d1- 4. This subunit origites from a single gene. The corresponding protein is modified by post-translatiol cleavage yielding a a2 subunit which is disulfide bonded to the d subunit. All a2d subunits are GPI- (glycosylphosphatidylinositol) anchored proteins3. The role of this subunit is important for the membrane trafficking of the a1 subunit, and also has a role in influencing the biophysical properties of the channel.a2d can be expressed as various splice variants and expressed in a tissue specific manner. a2d2 can be detected in the brain, heart, lung, spleen and liver.Gabapentin and pregabalin are two commonly used anti-epileptic drugs. They act on CaV channels via the a2d1 and a2d2 subunits by disturbing their membrane trafficking, thereby decreasing Ca2+ currents.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CACNA2D2 antibody

  Rabbit polyclonal CACNA2D2 Antibody (Center)  
CACNA2D2 Antibody (Center) (Cat. #TA324518) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the CACNA2D2 antibody detected the CACNA2D2 protein (arrow). Rabbit IgG Purified Ms ICC/IF, P, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

CACNA2D2 antibody

  Rabbit Polyclonal Anti-CaV alpha2delta2 (extracellular)  
Western blot analysis of rat lung (lanes 1 and 6), rat brain (lanes 2 and 7), Mouse brain (lanes 3 and 8), rat heart (lanes 4 and 9) and mouse heart (lanes 5 and 10) lysates: 1-5. Anti- Cava2d2 (extracellular) antibody, (1:200). 6-10. Anti- Cava2d2 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

CACNA2D2 antibody

  Rabbit Polyclonal Anti-CACNA2D2 Antibody  
WB Suggested Anti-CACNA2D2 Antibody; Titration: 1.0 ug/ml; Positive Control: HCT15 Whole Cell Rabbit IgG Purified Bov, Can, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

CACNA2D2 (65-163) antibody

Human Kidney, Tubules: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2a 3A4 Purified Hu E, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

CACNA2D2 - human gene knockout kit via CRISPR

CACNA2D2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

CACNA2D2 - human gene knockout kit via CRISPR

CACNA2D2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

CACNA2D2 - human gene knockout kit via CRISPR

CACNA2D2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

CACNA2D2 - human gene knockout kit via CRISPR

CACNA2D2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cacna2d2 - mouse gene knockout kit via CRISPR

Cacna2d2 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Cacna2d2 - mouse gene knockout kit via CRISPR

Cacna2d2 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cacna2d2 - mouse gene knockout kit via CRISPR

Cacna2d2 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cacna2d2 - mouse gene knockout kit via CRISPR

Cacna2d2 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CACNA2D2 (transcript variant 3)

  Recombinant protein of human calcium channel, voltage-dependent, alpha 2/delta subunit 2 (CACNA2D2), transcript variant 3.  
CACNA2D2 Human > 80 %
Preparation: or Add: Recombint proteins was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

CACNA2D2 overexpression lysate

CACNA2D2 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, CACNA2D2 (mGFP-tagged)-Human calcium channel, voltage-dependent, alpha 2/delta subunit 2 (CACNA2D2), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, CACNA2D2 (mGFP-tagged)-Human calcium channel, voltage-dependent, alpha 2/delta subunit 2 (CACNA2D2), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €2,270.00
  OriGene Technologies, Inc.

Lenti ORF particles, CACNA2D2 (mGFP-tagged)-Human calcium channel, voltage-dependent, alpha 2/delta subunit 2 (CACNA2D2), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, CACNA2D2 (mGFP-tagged)-Human calcium channel, voltage-dependent, alpha 2/delta subunit 2 (CACNA2D2), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €2,270.00
  OriGene Technologies, Inc.

Lenti ORF particles, CACNA2D2 (mGFP-tagged) - Human calcium channel, voltage-dependent, alpha 2/delta subunit 2 (CACNA2D2), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, CACNA2D2 (mGFP-tagged) - Human calcium channel, voltage-dependent, alpha 2/delta subunit 2 (CACNA2D2), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €2,280.00
  OriGene Technologies, Inc.

Lenti ORF particles, CACNA2D2 (Myc-DDK-tagged)-Human calcium channel, voltage-dependent, alpha 2/delta subunit 2 (CACNA2D2), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, CACNA2D2 (Myc-DDK-tagged)-Human calcium channel, voltage-dependent, alpha 2/delta subunit 2 (CACNA2D2), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €2,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, CACNA2D2 (Myc-DDK-tagged)-Human calcium channel, voltage-dependent, alpha 2/delta subunit 2 (CACNA2D2), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, CACNA2D2 (Myc-DDK-tagged)-Human calcium channel, voltage-dependent, alpha 2/delta subunit 2 (CACNA2D2), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €2,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, CACNA2D2 (Myc-DDK tagged) - Human calcium channel, voltage-dependent, alpha 2/delta subunit 2 (CACNA2D2), transcript variant 3 , 200 uL, >10^7 TU/mL

Lenti ORF particles, CACNA2D2 (Myc-DDK tagged) - Human calcium channel, voltage-dependent, alpha 2/delta subunit 2 (CACNA2D2), transcript variant 3 , 200 uL, >10^7 TU/mL  
200 µl / €2,060.00
  OriGene Technologies, Inc.

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