CACNA2D2 antibody

Principal name

CACNA2D2 antibody

Alternative names for CACNA2D2 antibody

KIAA0558, Voltage-dependent calcium channel subunit alpha-2/delta-2

SwissProt ID

Q6PHS9 (Mouse), Q8CFG6 (Rat), Q9NY47 (Human)

Gene ID

9254 (CACNA2D2), 300992 (Cacna2d2)

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse), Bov (Bovine), Can (Canine), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of CACNA2D2 antibody

Voltage-gated Ca2+ channels (CaV), eble the passage of Ca2+ ions in a voltage dependent manner. These heteromeric entities are formed in part by the pore-forming a1 subunit which determines the biophysical and pharmacological properties of the channel.CaV1 and CaV2 channels are high-voltage activated (HVA) CaV channels. The a1 subunit of these channels normally interacts and associates with a2d subunit, a membrane anchored protein and CaVÃ?, a cytosolic protein.Four a2d subunits have been cloned to date: a2d1- 4. This subunit origites from a single gene. The corresponding protein is modified by post-translatiol cleavage yielding a a2 subunit which is disulfide bonded to the d subunit. All a2d subunits are GPI- (glycosylphosphatidylinositol) anchored proteins3. The role of this subunit is important for the membrane trafficking of the a1 subunit, and also has a role in influencing the biophysical properties of the channel.a2d can be expressed as various splice variants and expressed in a tissue specific manner. a2d2 can be detected in the brain, heart, lung, spleen and liver.Gabapentin and pregabalin are two commonly used anti-epileptic drugs. They act on CaV channels via the a2d1 and a2d2 subunits by disturbing their membrane trafficking, thereby decreasing Ca2+ currents.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CACNA2D2 antibody

CACNA2D2 Antibody (Center) (Cat. #TA324518) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the CACNA2D2 antibody detected the CACNA2D2 protein (arrow). Rabbit IgG Purified Ms ICC/IF, P, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

CACNA2D2 antibody

Western blot analysis of rat lung (lanes 1 and 6), rat brain (lanes 2 and 7), Mouse brain (lanes 3 and 8), rat heart (lanes 4 and 9) and mouse heart (lanes 5 and 10) lysates: 1-5. Anti- Cava2d2 (extracellular) antibody, (1:200). 6-10. Anti- Cava2d2 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

CACNA2D2 antibody

WB Suggested Anti-CACNA2D2 Antibody; Titration: 1.0 ug/ml; Positive Control: HCT15 Whole Cell Rabbit IgG Purified Bov, Can, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

CACNA2D2 (65-163) antibody

Human Kidney, Tubules: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2a 3A4 Purified Hu E, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

CACNA2D2 antibody

CACNA2D2 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

CACNA2D2 antibody

CACNA2D2 Mouse IgG2a 3A4 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

CACNA2D2 antibody

CACNA2D2 monoclonal antibody (M12), clone 4E3. Western Blot analysis of CACNA2D2 expression in HeLa(Cat # L013V1 ). Mouse IgG2a 4E3 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

CACNA2D2 antibody

CACNA2D2 Rabbit Hu, Rt WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

CACNA2D2 antibody

Western blot analysis of CACNA2D2 expression in 293T (A); mouse brain (B); rat brain (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt P, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

CACNA2D2 antibody

Western blot analysis of CACNA2D2 expression in 293T (A); mouse brain (B); rat brain (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

CACNA2D2 antibody

Western blot analysis of CACNA2D2 expression in 293T (A); mouse brain (B); rat brain (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

CACNA2D2 antibody

CACNA2D2 Rabbit Serum Hu, Ms, Rt P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

CACNA2D2 antibody

Immunohistochemistry-Paraffin: CACNA2D2 Antibody [NBP1-81501] Immunohistochemical staining of human cerebellum shows strong cytoplasmic and nuclear positivity in purkinje cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CACNA2D2 (transcript variant 3)

CACNA2D2 Human > 80 %
Preparation: or Add: Recombint proteins was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

CACNA2D2

CACNA2D2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

CACNA2D2

CACNA2D2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

CACNA2D2 overexpression lysate

CACNA2D2 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

17 Item(s)

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