CACNA2D3 antibody

Principal name

CACNA2D3 antibody

Alternative names for CACNA2D3 antibody

Voltage-dependent calcium channel subunit alpha-2/delta-3, Voltage-gated calcium channel subunit alpha-2/delta-3

SwissProt ID

Q8CFG5 (Rat), Q8IZS8 (Human), Q9Z1L5 (Mouse)

Gene ID

55799 (CACNA2D3), 306243 (Cacna2d3)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Goat

Available applications

Frozen Sections (C), Paraffin Sections (P), Western blot / Immunoblot (WB), Flow Cytometry (F)

Background of CACNA2D3 antibody

Voltage-gated Ca2+ (CaV) channels are ubiquitously expressed and function as Ca2+ conducting pores in the plasma membrane1. On the basis of their voltage activation properties, CaV channels can be further divided into two broad groups: the low (T-type) and high (L, N, P, Q and R-type) threshold-activated channels. HVA channels are heteromultimers composed of four independently encoded proteins, the pore-forming a1 subunit, which triggers Ca2+ flow across the membrane, and the auxiliary subunits a2d, ?, and Ã?. The Ca2+ channel a2d subunit is a heavily glycosylated protein that is encoded by a single gene and post-translatiolly cleaved to yield a2 and d subunits linked by a disulfide bond with a single transmembrane segment.The a2d subunit regulates many functiol aspects of Ca2+ channels, such as gating, regulating voltage dependent kinetics, and increasing functiol channel density on the plasma membrane.There are four proteins that comprise CaVa2d: CaVa2d1, CaVa2d2, CaVa2d3 and CaVa2d46. The CaVa2d3 subunit is predomintly expressed in neurol tissue. The CaVa2d3 subunit regulates all classes of HVA calcium channels. The Caa2d3 subunits in the nerve termil function in syptic morphogenesis and cytoskeletal organization, and that this role is independent of their function in a1 subunit localization and physiology.CaVa2d3 is likely to be the primary presyptic a2d isoform mediating morphological development of the neuromuscular junction (NMJ), since alleles have such a large effect on NMJ development and abolish all action-potential evoked transmission. Recent study shows that methylation-dependent transcriptiol silencing of CaVa2d3 may contribute to the metastatic phenotype of breast cancer.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CACNA2D3 (C-term) antibody

Western blot analysis of CACNA2D3 Antibody (C-term) (Cat. #TA325110) in HepG2 cell line lysates (35ug/lane). CACNA2D3 (arrow) was detected using the purified Pab. Rabbit Ig Aff - Purified Hu F, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

CACNA2D3 antibody

Western blot analysis of rat brain (lanes 1 and 3) and K562 (lanes 2 and 4) lysates: 1, 2. Anti-CaVa2d3 (extracellular) antibody, (1:200). 3, 4. Anti-CaVa2d3 (extracellular) antibody preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

CACNA2D3 antibody

Western blot analysis of CACNA2D3 expression in human brain (A); mouse brain (B) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

CACNA2D3 antibody

Western blot analysis of CACNA2D3 expression in human brain (A); mouse brain (B) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

CACNA2D3 antibody

Western blot analysis of CACNA2D3 expression in human brain (A); mouse brain (B) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

CACNA2D3 antibody

CACNA2D3 Rabbit Serum Hu, Ms, Rt C, P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

CACNA2D3 antibody

CACNA2D3 Rabbit IgG Hu, Ms, Rt C, WB
0.5 mg / €400.00
  Novus Biologicals Inc.

CACNA2D3 antibody

CACNA2D3 Goat Purified Hu, Ms, Rt C, P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

Lysates

Catalog No.    

CACNA2D3 overexpression lysate

CACNA2D3 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

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