CACNB1 antibody

Principal name

CACNB1 antibody

Alternative names for CACNB1 antibody

CAB1, CACNLB1, Voltage-dependent L-type calcium channel subunit beta-1, Calcium channel voltage-dependent subunit beta 1

SwissProt ID

P54283 (Rat), Q02641 (Human), Q8R3Z5 (Mouse), Q9MZL7 (Bovin)

Gene ID

782 (CACNB1), 50688 (Cacnb1), 12295

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Ms (Mouse), Rb (Rabbit), Rt (Rat), Ze (Zebrafish), African clawed frog, Chk (Chicken), Por (Porcine), Eq (Equine), GP (Guinea Pig)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Paraffin Sections (P), Immunoprecipitation (IP), Frozen Sections (C)

Background of CACNB1 antibody

Voltage-gated Ca2+ (CaV) channels are ubiquitously expressed and function as Ca2+ conducting pores in the plasma membrane1. Based on their electrophysiological and pharmacological properties, CaV channels have traditiolly been classified into L, T, N, P, Q, and R types. L-type Ca2+ channels are heteromultimers composed of four independently encoded proteins, the pore-forming a1 subunit, which triggers Ca2+ flow across the membrane, and the subunits a2d, ?, and Ã?.CaVÃ? subunits play critical roles in membrane trafficking of the channel complex and regulation of voltage-dependent gating. The CaVÃ? subunit binds to the endoplasmic reticulum (ER) retention sigl in the I-II loop of the a1-subunit, which allows channels to traffic to the surface membrane4. Furthermore, CaVÃ? subunits not only allow for membrane trafficking of the channel complex, they also can play a role in determining the subcellular localization of channels on the surface membrane. There are four distinct CaVÃ? subunits CaVÃ?1, CaVÃ?2, CaVÃ?3 and CaVÃ?4.Three splice variants exist for the Ã?1 subunit: Ã?1a, Ã?1b and Ã?1c. Ã?1a is known to be expressed in skeletal muscle and brain, but not in smooth muscle or heart. Ã?1a appears to be important for the functiol expression of the a1 subunit in skeletal muscle. Ã?1b was identified by cloning in rat brain, heart and hippocampus, and differs from Ã?1a by having a deletion of ~50 amino acids at residue 209, and having a 120-residue C-termil elongation. Ã?1c was cloned from human heart and hippocampus and has the same deletion as Ã?1b, but lacks the C-termil extension.

General readings

Hogan,K., et al., (1999) Neurosci. Lett. 277 (2), 111-114

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CACNB1 antibody

  Rabbit Polyclonal Anti-CACNB1 Antibody  
WB Suggested Anti-CACNB1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

CACNB1 antibody

  Rabbit Polyclonal Anti-CaVBeta1  
Western blot analysis of rat brain (lanes 1 and 4), mouse brain (lanes 2 and 5) and rat cortex (lane 3 and 6): 1-3. Anti-CaVß1 antibody, (1:800). 4-6. Anti-CaVß1 antibody preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
50 µl / €325.00
  OriGene Technologies, Inc.

CACNB1 antibody

  Rabbit Polyclonal Anti-CACNB1 Antibody  
WB Suggested Anti-CACNB1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Human brain Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

CACNB1 antibody

  Rabbit Polyclonal Anti-CACNB1 Antibody  
WB Suggested Anti-CACNB1 Antibody Titration: 0.2-1 ug/ml; Positive Control: Jurkat cell lysate Rabbit IgG Purified Bov, GP, Hu, Ms, Rb P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

CACNB1 antibody

  Rabbit Polyclonal Anti-CACNB1 Antibody  
WB Suggested Anti-CACNB1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: COLO205 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

CACNB1 antibody

  Rabbit Polyclonal Anti-CACNB1 Antibody  
WB Suggested Anti-CACNB1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: MCF7 cell lysate Rabbit IgG Purified Bov, GP, Hu, Ms, Rb, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

CACNB1 antibody

  Rabbit Polyclonal Anti-CACNB1 Antibody  
CACNB1 Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CACNB1 antibody

immunoblot against crude membrane fractions from whole mouse (MBM) or rat (RBM) brain and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] or cerebellum [HBM(Cb)] and probed with N7/18 (left) or N52A/42 (right) TC supe. Mouse IgG2a N7/18 Supernatant Hu, Ms, Rt C, IP, WB
5 ml / €460.00
  Antibodies Incorporated

NeuroMab

CACNB1 antibody

immunoblot against crude membrane fractions from whole mouse (MBM) or rat (RBM) brain and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] or cerebellum [HBM(Cb)] and probed with N7/18 (left) or N52A/42 (right) TC supe. Mouse IgG2a N7/18 Purified Hu, Ms, Rt C, IP, WB
0.1 ml / €540.00
  Antibodies Incorporated

NeuroMab

CACNB1 antibody

CACNB1 Rabbit IgG Purified Hu WB
0.1 mg / €370.00
  Acris Antibodies GmbH

CACNB1 (C-term) antibody

CACNB1 Antibody (C-term) (Cat. #AP50704PU-N) western blot analysis in HepG2 cell line lysates (35µg/lane).This demonstrates the CACNB1 antibody detected the CACNB1 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

CACNB1 - human gene knockout kit via CRISPR

CACNB1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

CACNB1 - human gene knockout kit via CRISPR

CACNB1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

CACNB1 - human gene knockout kit via CRISPR

CACNB1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

CACNB1 - human gene knockout kit via CRISPR

CACNB1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CACNB1 (transcript variant 1)

  Recombinant protein of human calcium channel, voltage-dependent, beta 1 subunit (CACNB1), transcript variant 1  
CACNB1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

CACNB1 (transcript variant 2)

  Recombinant protein of human calcium channel, voltage-dependent, beta 1 subunit (CACNB1), transcript variant 2  
CACNB1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

CACNB1 overexpression lysate

CACNB1 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

CACNB1 overexpression lysate

CACNB1 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

CACNB1 overexpression lysate

CACNB1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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