CACNB3 antibody
Principal name
CACNB3 antibody
Alternative names for CACNB3 antibody
CAB3, CACNLB3, Voltage-dependent L-type calcium channel subunit beta-3, Calcium channel voltage-dependent subunit beta 3
Ncbi ID
NP_000716, NP_036960.1, NP_000716.2, 9606, 10116, CAA54056, NM_000725
Available reactivities
Available hosts
Available applications
Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Paraffin Sections (P), Frozen Sections (C), Enzyme Immunoassay (E)
Background of CACNB3 antibody
Voltage-sensitive calcium channels (VSCCs) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-ctx-GVIA) and omega-agatoxin-IVA (omega-aga-IVA). The overall conclusion is that deletion of the beta 3 subunit affects at least three distinct types of High voltage activated Ca2+ channel (L,N and P/Q types), but no single type of channel is solely dependent on beta 3.
General readings
Murakami,M., et al., (1996) Eur. J. Biochem. 236 (1), 138-143
