CACNB3 antibody

Principal name

CACNB3 antibody

Alternative names for CACNB3 antibody

CAB3, CACNLB3, Voltage-dependent L-type calcium channel subunit beta-3, Calcium channel voltage-dependent subunit beta 3

SwissProt ID

P54284 (Human), P54285 (Mouse), P54287 (Rat), Q9MZL3 (Bovin)

Gene ID

784 (CACNB3), 25297 (Cacnb3)

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Ms (Mouse), Rb (Rabbit), Rt (Rat), African clawed frog, Chk (Chicken), Ze (Zebrafish), Eq (Equine), GP (Guinea Pig), Por (Porcine)

Available hosts

Rabbit, Mouse, Goat

Available applications

Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Paraffin Sections (P), Frozen Sections (C), Enzyme Immunoassay (E)

Background of CACNB3 antibody

Voltage-sensitive calcium channels (VSCCs) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-ctx-GVIA) and omega-agatoxin-IVA (omega-aga-IVA). The overall conclusion is that deletion of the beta 3 subunit affects at least three distinct types of High voltage activated Ca2+ channel (L,N and P/Q types), but no single type of channel is solely dependent on beta 3.

General readings

Murakami,M., et al., (1996) Eur. J. Biochem. 236 (1), 138-143

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