CACNB4 antibody

Principal name

CACNB4 antibody

Alternative names for CACNB4 antibody

CAB4, CACNLB4, Voltage-dependent L-type calcium channel subunit beta-4, Calcium channel voltage-dependent subunit beta 4

SwissProt ID

D4A055 (Rat), O00305 (Human), Q8R0S4 (Mouse)

Gene ID

785 (CACNB4), 58942 (Cacnb4), 12298

Available reactivities

Can (Canine), Chk (Chicken), Hu (Human), Ms (Mouse), Por (Porcine), Rb (Rabbit), Rt (Rat), Ze (Zebrafish), Bov (Bovine), African clawed frog, Eq (Equine), GP (Guinea Pig)

Available hosts

Rabbit, Mouse, Goat

Available applications

Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Frozen Sections (C)

Background of CACNB4 antibody

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces.
There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligandgated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotidegated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inwardrectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2).
Specifically, this gene encodes a member of the beta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein described in this record plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized (3, 4).

General readings

Badou A, Basavappa S, Desai R, Peng YQ, Matza D, Mehal WZ, Kaczmarek LK, Boulpaep EL, Flavell RA. Requirement of voltage-gated calcium channel beta4 subunit for T lymphocyte functions. Science. 2005 Jan 7;307(5706):117-21.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CACNB4 antibody

  Rabbit Polyclonal Anti-CACNB4 Antibody  
WB Suggested Anti-CACNB4 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: MCF7 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

CACNB4 antibody

Adult rat brain membrane immunoblot. Mouse IgG1 N10/7 Supernatant Hu, Ms, Rt C, IP, WB
5 ml / €460.00
  Antibodies Incorporated

NeuroMab

CACNB4 antibody

Adult rat brain membrane immunoblot. Mouse IgG1 N10/7 Purified Hu, Ms, Rt C, IP, WB
0.1 ml / €540.00
  Antibodies Incorporated

NeuroMab

CACNB4 (C-term) antibody

  Goat Polyclonal Antibody against CACNB4 (C terminus)  
TA302437 (0.2µg/ml) staining of human bone marrow lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Hu, Ms, Por, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CACNB4 antibody

  Goat Polyclonal Antibody against CACNB4 (internal)  
TA302438 (0.2µg/ml) staining of Human Bone Marrow lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CACNB4 antibody

  Mouse monoclonal CaVbeta4 Antibody  
Western blot analysis of CavBeta4 in T-CHO lysates using a 1:1000 dilution of the antibody Mouse IgG1 S10-7 Purified Hu, Ms, Rt C, ICC/IF, IP, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CACNB4 antibody

  Rabbit Polyclonal Anti-CACNB4 Antibody  
WB Suggested Anti-CACNB4 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:12500; Positive Control: Jurkat cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

CACNB4 antibody

Western blot analysis using beta4 antibody on rat brain lysate. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

CACNB4 - human gene knockout kit via CRISPR

CACNB4 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

CACNB4 - human gene knockout kit via CRISPR

CACNB4 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

CACNB4 - human gene knockout kit via CRISPR

CACNB4 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

CACNB4 - human gene knockout kit via CRISPR

CACNB4 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cacnb4 - mouse gene knockout kit via CRISPR

Cacnb4 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CACNB4 (transcript variant 2)

  Recombinant protein of human calcium channel, voltage-dependent, beta 4 subunit (CACNB4), transcript variant 2  
CACNB4 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

Lysates

Catalog No.    

CACNB4 overexpression lysate

CACNB4 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

CACNB4 overexpression lysate

CACNB4 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

CACNB4 overexpression lysate

CACNB4 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

CACNB4 overexpression lysate

CACNB4 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, CACNB4 (mGFP-tagged) - Human calcium channel, voltage-dependent, beta 4 subunit (CACNB4), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, CACNB4 (mGFP-tagged) - Human calcium channel, voltage-dependent, beta 4 subunit (CACNB4), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,100.00
  OriGene Technologies, Inc.

Lenti ORF particles, CACNB4 (mGFP-tagged) - Human calcium channel, voltage-dependent, beta 4 subunit (CACNB4), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, CACNB4 (mGFP-tagged) - Human calcium channel, voltage-dependent, beta 4 subunit (CACNB4), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

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