CACYBP antibody

Principal name

CACYBP antibody

Alternative names for CACYBP antibody

Calcyclin-binding protein, S100A6BP, SIP, PNAS-107, Siah-interacting protein, S100A6-binding protein

SwissProt ID

Q3T168 (Bovin), Q6AYK6 (Rat), Q9CXW3 (Mouse), Q9HB71 (Human)

Gene ID

27101 (CACYBP), 12301 (Cacybp), 289144

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Chk (Chicken), Ms (Mouse), Rt (Rat), African clawed frog, Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Paraffin Sections (P)

Background of CACYBP antibody

CACYBP(Calcyclin-binding protein), also called SIP, is a protein that in humans is encoded by the CACYBP gene. The full-length SIP cDNA encodes a predicted 228-amino acid protein. Sequence analysis of the shortest cDNA derived by 2-hybrid screening revealed an 8-amino acid difference in the deduced open reading frame followed by a stop codon, resulting in a predicted 80-amino acid protein, SIP-short (SIPS). The CACYBP gene is mapped on 1q25.1. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. The C-terminal region of SIP that is homologous to SGT1 was able to complement defects in yeast strains containing SGT1 mutant alleles, demonstrating conservation of SGT1 and SIP protein function.

General readings

1. Matsuzawa, S., Reed, J. C. Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin
degradation linked to p53 responses.Molec. Cell 7: 915-926, 2001.
2. Sun S, Ning X, Liu J, et al. (2007). "Overexpressed CacyBP/SIP leads to the suppression of growth
in renal cell carcinoma.". Biochem. Biophys. Res. Commun. 356 (4): 864–71

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CACYBP antibody

  Rabbit Polyclonal antibody to CacyBP (calcyclin binding protein)  
Sample (50 ug of whole cell lysate). A: mouse brain. 12% SDS PAGE. TA308595 diluted at 1:1000. Rabbit IgG Aff - Purified Hu, Ms ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CACYBP antibody

  Rabbit Polyclonal Anti-CACYBP  
WB Suggested Anti-CACYBP Antibody Titration: 5.0 ug/ml; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CACYBP antibody

Immunohistochemical analysis of paraffin-embedded human brain glioma tissue showing nuclear localization using calcyclin mouse mAb with DAB staining. Mouse IgG1 7D11 Purified Hu E, P, WB
0.1 ml / €360.00
  Acris Antibodies GmbH

CACYBP antibody

The cell lysates of HeLa, 293T, Jurkat and A549(40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human CACYBP antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG2a AT3G8 Purified Hu E, WB
0.1 ml / €310.00
  Acris Antibodies GmbH

CACYBP antibody

The cell lysates of HeLa, 293T, Jurkat and A549(40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human CACYBP antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG2a AT3G8 Purified Hu E, WB
50 µl / €220.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

CACYBP - human gene knockout kit via CRISPR

CACYBP - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

CACYBP - human gene knockout kit via CRISPR

CACYBP - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

CACYBP - human gene knockout kit via CRISPR

CACYBP - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

CACYBP - human gene knockout kit via CRISPR

CACYBP - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cacybp - mouse gene knockout kit via CRISPR

Cacybp - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Cacybp - mouse gene knockout kit via CRISPR

Cacybp - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cacybp - mouse gene knockout kit via CRISPR

Cacybp - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cacybp - mouse gene knockout kit via CRISPR

Cacybp - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CACYBP (transcript variant 1)

  Recombinant protein of human calcyclin binding protein (CACYBP), transcript variant 1  
CACYBP Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

CACYBP (transcript variant 2)

  Recombinant protein of human calcyclin binding protein (CACYBP), transcript variant 2  
CACYBP Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

CACYBP (1-185, His-tag)

Recombinant human CACYBP, His-tagged: 15% SDS-PAGE (3 ug) Human Purified > 85 % by SDS – PAGE E. coli
0.5 mg / €670.00
  Acris Antibodies GmbH

CACYBP (1-185, His-tag)

Recombinant human CACYBP, His-tagged: 15% SDS-PAGE (3 ug) Human Purified > 85 % by SDS – PAGE E. coli
0.1 mg / €250.00
  Acris Antibodies GmbH

Lysates

Catalog No.    

CACYBP overexpression lysate

CACYBP overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Cacybp (GFP-tagged) - Mouse calcyclin binding protein (Cacybp), 200 uL, >10^7 TU/mL

Lenti ORF particles, Cacybp (GFP-tagged) - Mouse calcyclin binding protein (Cacybp), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Cacybp (Myc-DDK-tagged) - Mouse calcyclin binding protein (Cacybp), 200 uL, >10^7 TU/mL

Lenti ORF particles, Cacybp (Myc-DDK-tagged) - Mouse calcyclin binding protein (Cacybp), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

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