Cadherin-2 antibody

Principal name

Cadherin-2 antibody

Alternative names for Cadherin-2 antibody

CDH2, CDHN, NCAD, Neural cadherin, CDw325, Cadherin N, N-Cadherin

SwissProt ID

P10288 (Chick), P15116 (Mouse), P19022 (Human), P19534 (Bovin), Q90275, Q9Z1Y3 (Rat)

Gene ID

1000 (CDH2), 83501 (Cdh2), 12558

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Chk (Chicken), Rb (Rabbit), Can (Canine), Mky (Monkey), Bov (Bovine), Ze (Zebrafish)

Available hosts

Mouse, Rabbit, Goat

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Frozen Sections (C), Flow Cytometry (F)

Background of Cadherin-2 antibody

Cadherins are a superfamily of transmembrane glycoproteins that contain cadherin repeats of approximately 100 residues in their extracellular domain. Cadherins mediate calcium-dependent cell-cell adhesion and play critical roles in normal tissue development. The classic cadherin subfamily includes N-, P-, R-, B- and E-cadherins, as well as about ten other members that are found in adherens junctions, a cellular structure near the apical surface of polarized epithelial cells. The cytoplasmic domain of classical cadherins interacts with ß-catenin, ?-catenin (also called plakoglobin), and p120 catenin. ß-catenin and ?-catenin associate with a-catenin, which links the cadherin-catenin complex to the actin cytoskeleton. While ß- and ?-catenin play structural roles in the junctiol complex, p120 regulates cadherin adhesive activity and trafficking. E-cadherin is considered an active suppressor of invasion and growth of many epithelial cancers. Recent studies indicate that cancer cells have up-regulated N-cadherin in addition to loss of E-cadherin. This change in cadherin expression is called the "cadherin switch". N-cadherin cooperates with the FGF receptor, leading to overexpression of MMP-9 and cellular invasion. In endothelial cells, VE-cadherin sigling, expression, and localization correlate with vascular permeability and tumor angiogenesis. Expression of P-cadherin, which is normally present in epithelial cells, is also altered in ovarian and other human cancers.

General readings

1 Miyatani, S.; Copeland, N. G.; Gilbert, D. J.; Jenkins, N. A.; Takeichi, M. : Genomic structure and chromosomal mapping of the mouse N-cadherin gene. Proc. Nat. Acad. Sci. 89: 8443-8447, 1992.
2 Walsh, F. S.; Barton, C. H.; Putt, W.; Moore, S. E.; Kelsell, D.; Spurr, N.; Goodfellow, P. N.: N-cadherin gene maps to human chromosome 18 and is not linked to the E-cadherin gene. J. Neurochem. 55: 805-812, 1990.
3 Togashi, H.; Abe, K.; Mizoguchi, A.; Takaoka, K.; Chisaka, O.; Takeichi, M. : Cadherin regulates dendritic spine morphogenesis. Neuron 35: 77-89, 2002.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Cadherin-2 antibody

  CDH2 (N Cadherin) mouse monoclonal antibody, clone OTI2G7 (formerly 2G7)  
Immunohistochemical staining of paraffin-embedded Human liver tissue within the normal limits using anti-CDH2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA503933) Mouse IgG2a OTI2G7 Purified Can, Hu, Mky, Ms F, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

Cadherin-2 antibody

  CDH2 mouse monoclonal antibody,clone UMAB23  
Immunohistochemical staining of paraffin-embedded Carcinoma of liver tissue using anti-CDH2 mouse monoclonal antibody. (Clone UMAB23, dilution 1:100; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG2a UMAB23 Purified Hu F, P, WB
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

Cadherin-2 antibody

  CDH2 mouse monoclonal antibody,clone UMAB23  
Immunohistochemical staining of paraffin-embedded Carcinoma of liver tissue using anti-CDH2 mouse monoclonal antibody. (Clone UMAB23, dilution 1:100; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG2a UMAB23 Purified Hu F, P, WB
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

Cadherin-2 antibody

  Rabbit Monoclonal anti-Cadherin-N/N-Cadherin Antibody  
Human Mesothelioma stained with anti-Cadherin-N_N-Cadherin antibody. Rabbit IgG SP90 Purified Hu F, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Cadherin-2 antibody

  CDH2 (N Cadherin) mouse monoclonal antibody, clone OTI3B10 (formerly 3B10)  
Immunohistochemical staining of paraffin-embedded Carcinoma of Human thyroid tissue using anti-CDH2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA503775) Mouse IgG2a OTI3B10 Purified Hu F, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Cadherin-2 antibody

Immunohistochemical analysis of paraffin-embedded human lung cancer (A), colon cancer (B), ovarian cancer (C) and mammary cancer(D), using CDH2 antibody Cat.-No AM06440SU-N with DAB staining. Mouse IgG1 5D5 Ascites Hu, Ms, Rt E, F, ICC/IF, P, WB
0.1 ml / €400.00
  Acris Antibodies GmbH

Cadherin-2 (C-term) antibody

Cadherin-2 Goat IgG Aff - Purified Can, Hu, Mky, Ms, Rt WB
20 µl / €50.00
  SICGEN

Cadherin-2 (C-term) antibody

Cadherin-2 Goat IgG Aff - Purified Can, Hu, Mky, Ms, Rt WB
0.6 mg / €300.00
  SICGEN

Cadherin-2 antibody

  Mouse Anti-Human CD325 (N-Cadherin) Purified (25 ug)  
Staining of HeLa cells with 0.25 ug of Mouse IgG1 K Isotype Control Purified (open histogram) or 0.25 ug of Anti-Human CD325 (N-Cadherin) Purified (filled histogram) followed by F(ab')2 Anti-Mouse IgG PE .  Total viable cells were used for analysis. Mouse 8C11 Purified Hu F
25 µg / €120.00
  OriGene Technologies, Inc.

Cadherin-2 antibody

  N-cadherin Rabbit Polyclonal Antibody  
Western blot analysis of extracts from C6 cell lysate using N-cadherin antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Cadherin-2 antibody

  CDH2 Rabbit Polyclonal Antibody  
Western blot analysis of extracts of U251 cell line, using CDH2 antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Cadherin-2 antibody

  Mouse Monoclonal N-Cadherin Antibody (13A9)  
Western Blot: N Cadherin Antibody (13A9) [TA336779] - Analysis of N Cadherin expression in HeLa whole cell lysate. Mouse IgG1 13A9 Purified Hu, Ms, Rt C, ICC/IF, IP, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Cadherin-2 antibody

  Rabbit Polyclonal Anti-N-Cadherin Antibody  
Western blot analysis of extract cefrom HT29 lls using N-Cadherin antibody Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Cadherin-2 antibody

  Rabbit Polyclonal Anti-CDH2 Antibody  
Western blot analysis of CDH2 expression in Jurkat cells Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

Cadherin-2 antibody

  Rabbit Polyclonal anti-Cadherin-N/N-Cadherin Antibody  
Human Liver stained with anti-Cadherin-N_N-Cadherin antibody. Rabbit IgG Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Cadherin-2 antibody

  Rabbit Polyclonal N Cadherin Antibody  
Western Blot: N Cadherin Antibody - Western Blot was performed using affinity purified SEQer CDH2 antibody, aa(59-158) antibody. The lanes contain 5-30ug of a whole cell extract.  Final concentration of antibodies = 0.1ug/ml (1:10,000 dilution). The blot was probed overnight with the SEQer CDH2 antibody, aa(59-158) antibody.  Blot was then washed according to protocol and probed with goat-anti-Rabbit-HRP conjugate at 1:5000 dilution, washed and developed using chemiluminescence (film exposure 5-30sec).  The protein was detected as represented by the band shown. Rabbit IgG Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Cadherin-2 antibody

  CDH2 mouse monoclonal antibody, clone OTI1C5 (formerly 1C5)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CDH2 (RC207170, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CDH2. Mouse IgG1 OTI1C5 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Cadherin-2 antibody

  CDH2 mouse monoclonal antibody, clone OTI4G1 (formerly 4G1)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CDH2 (RC207170, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CDH2. Mouse IgG1 OTI4G1 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Cadherin-2 antibody

  CDH2 mouse monoclonal antibody, clone OTI5F8 (formerly 5F8)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CDH2 (RC207170, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CDH2. Mouse IgG2b OTI5F8 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Cadherin-2 antibody

  CDH2 mouse monoclonal antibody, clone OTI6E5 (formerly 6E5)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CDH2 (RC207170, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CDH2.(1:2000) Mouse IgG1 OTI6E5 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

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