Cadherin-2 antibody

Principal name

Cadherin-2 antibody

Alternative names for Cadherin-2 antibody

CDH2, CDHN, NCAD, Neural cadherin, CDw325, Cadherin N, N-Cadherin

SwissProt ID

P10288 (Chick), P15116 (Mouse), P19022 (Human), P19534 (Bovin), Q90275, Q9Z1Y3 (Rat)

Gene ID

1000 (CDH2), 414745, 83501 (Cdh2), 170558, 30291 (cdh2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Rb (Rabbit), Bov (Bovine), Chk (Chicken), Amph (Amphibian), Av (Birds), Can (Canine), Fi (Fish), Xen (Xenopus), Ze (Zebrafish), Mky (Monkey)

Available hosts

Mouse, Rabbit, Goat

Available applications

Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Enzyme Immunoassay (E), Flow Cytometry (F), Paraffin Sections (P), Frozen Sections (C), Whole mount Immunohistochemistry (IHC-wm)

Background of Cadherin-2 antibody

Cadherins are a superfamily of transmembrane glycoproteins that contain cadherin repeats of approximately 100 residues in their extracellular domain. Cadherins mediate calcium-dependent cell-cell adhesion and play critical roles in normal tissue development. The classic cadherin subfamily includes N-, P-, R-, B- and E-cadherins, as well as about ten other members that are found in adherens junctions, a cellular structure near the apical surface of polarized epithelial cells. The cytoplasmic domain of classical cadherins interacts with ß-catenin, ?-catenin (also called plakoglobin), and p120 catenin. ß-catenin and ?-catenin associate with a-catenin, which links the cadherin-catenin complex to the actin cytoskeleton. While ß- and ?-catenin play structural roles in the junctiol complex, p120 regulates cadherin adhesive activity and trafficking. E-cadherin is considered an active suppressor of invasion and growth of many epithelial cancers. Recent studies indicate that cancer cells have up-regulated N-cadherin in addition to loss of E-cadherin. This change in cadherin expression is called the "cadherin switch". N-cadherin cooperates with the FGF receptor, leading to overexpression of MMP-9 and cellular invasion. In endothelial cells, VE-cadherin sigling, expression, and localization correlate with vascular permeability and tumor angiogenesis. Expression of P-cadherin, which is normally present in epithelial cells, is also altered in ovarian and other human cancers.

General readings

1 Miyatani, S.; Copeland, N. G.; Gilbert, D. J.; Jenkins, N. A.; Takeichi, M. : Genomic structure and chromosomal mapping of the mouse N-cadherin gene. Proc. Nat. Acad. Sci. 89: 8443-8447, 1992.
2 Walsh, F. S.; Barton, C. H.; Putt, W.; Moore, S. E.; Kelsell, D.; Spurr, N.; Goodfellow, P. N.: N-cadherin gene maps to human chromosome 18 and is not linked to the E-cadherin gene. J. Neurochem. 55: 805-812, 1990.
3 Togashi, H.; Abe, K.; Mizoguchi, A.; Takaoka, K.; Chisaka, O.; Takeichi, M. : Cadherin regulates dendritic spine morphogenesis. Neuron 35: 77-89, 2002.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Cadherin-2 antibody

Immunohistochemical staining of paraffin-embedded Human liver tissue within the normal limits using anti-CDH2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA503933) Mouse IgG2a OTI2G7 Purified Can, Hu, Mky, Ms F, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

Cadherin-2 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of liver tissue using anti-CDH2 mouse monoclonal antibody. (Clone UMAB23, dilution 1:100; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG2a UMAB23 Purified Hu F, P, WB
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

Cadherin-2 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of liver tissue using anti-CDH2 mouse monoclonal antibody. (Clone UMAB23, dilution 1:100; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG2a UMAB23 Purified Hu F, P, WB
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

Cadherin-2 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human thyroid tissue using anti-CDH2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA503775) Mouse IgG2a OTI3B10 Purified Hu F, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Cadherin-2 antibody

Immunohistochemical analysis of paraffin-embedded human lung cancer (A), colon cancer (B), ovarian cancer (C) and mammary cancer(D), using CDH2 antibody Cat.-No AM06440SU-N with DAB staining. Mouse IgG1 5D5 Ascites Hu, Ms, Rt E, F, ICC/IF, P, WB
0.1 ml / €400.00
  Acris Antibodies GmbH

Cadherin-2 antibody

Immunohistochemistry-Paraffin: N Cadherin Antibody (5D5) [NBP1-51612] - Immunohistochemical analysis of paraffin-embedded human lung cancer (A), colon cancer (B), ovarian cancer (C) and mammary cancer(D), using CDH2 mouse mAb with DAB staining. Mouse IgG1 5D5 Purified Hu, Ms, Rt E, F, ICC/IF, P, WB
0.1 ml / €420.00
  Novus Biologicals Inc.

Cadherin-2 (C-term) antibody

Cadherin-2 Goat IgG Aff - Purified Can, Hu, Mky, Ms, Rt WB
20 µl / €50.00
  SICGEN

Cadherin-2 (C-term) antibody

Cadherin-2 Goat IgG Aff - Purified Can, Hu, Mky, Ms, Rt WB
0.6 mg / €300.00
  SICGEN

Cadherin-2 (C-term) antibody

Human Mesothelioma stained with N-Cadherin Antibody Cat.-No AM21047PU (Clone SP90). Rabbit IgG SP90 Purified Hu F, P
0.5 ml / €510.00
  Acris Antibodies GmbH

Cadherin-2 (C-term) antibody

Human Mesothelioma stained with N-Cadherin Antibody Cat.-No AM21047PU (Clone SP90). Rabbit IgG SP90 Purified Hu F, P
1 ml / €730.00
  Acris Antibodies GmbH

Cadherin-2 (C-term) antibody

Human Mesothelioma stained with N-Cadherin Antibody Cat.-No AM21047PU (Clone SP90). Rabbit IgG SP90 Purified Hu F, P
0.1 ml / €290.00
  Acris Antibodies GmbH

Cadherin-2 antibody

AP15675PU N-Cadehrin antibody staining of Human Liver. Rabbit Purified Hu P
0.5 ml / €360.00
  Acris Antibodies GmbH

Cadherin-2 antibody

AP15675PU N-Cadehrin antibody staining of Human Liver. Rabbit Purified Hu P
1 ml / €520.00
  Acris Antibodies GmbH

Cadherin-2 antibody

AP15675PU N-Cadehrin antibody staining of Human Liver. Rabbit Purified Hu P
0.1 ml / €190.00
  Acris Antibodies GmbH

Cadherin-2 antibody

Staining of HeLa cells with 0.25 ug of Mouse IgG1 K Isotype Control Purified (open histogram) or 0.25 ug of Anti-Human CD325 (N-Cadherin) Purified (filled histogram) followed by F(ab')2 Anti-Mouse IgG PE .  Total viable cells were used for analysis. Mouse 8C11 Purified Hu F
25 µg / €120.00
  OriGene Technologies, Inc.

Cadherin-2 antibody

Predicted band size: 100 kDa . Positive control: Human brain malignant glioma tissue lysate. Recommended dilution: 1/200-1000 Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Cadherin-2 antibody

Western blot analysis of extracts from C6 cell lysate using N-cadherin antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Cadherin-2 antibody

Western blot analysis of extracts of U251 cell line, using CDH2 antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Cadherin-2 antibody

Western Blot: N Cadherin Antibody (13A9) [TA336779] - Analysis of N Cadherin expression in HeLa whole cell lysate. Mouse IgG1 13A9 Purified Hu, Ms, Rt C, ICC/IF, IP, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Cadherin-2 antibody

Western blot analysis of extract cefrom HT29 lls using N-Cadherin antibody Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

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