CADM1 / SYNCAM antibody

Principal name

CADM1 / SYNCAM antibody

Alternative names for CADM1 / SYNCAM antibody

IGSF4, IGSF4A, NECL2, TSLC1, NECL-2, SgIgSF, TSLC-1, Cell adhesion molecule 1, Immunoglobulin superfamily member 4, IgSF4, Nectin-like protein 2, Tumor suppressor in lung cancer 1, Spermatogenic immunoglobulin superfamily, Synaptic cell adhesion molecule

SwissProt ID

Q6AYP5 (Rat), Q8R5M8 (Mouse), Q9BY67 (Human)

Gene ID

23705 (CADM1), 54725 (Cadm1), 363058

Available reactivities

Hu (Human), Rt (Rat), Bov (Bovine), Can (Canine), Ms (Mouse), Por (Porcine)

Available hosts

Mouse, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of CADM1 / SYNCAM antibody

Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. May act as a synaptic cell adhesion molecule that drives synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.

General readings

1. Berginc G, Bracko M, Glavac D, MS-MLPA reveals progressive age-dependent promoter methylation of tumor suppressor genes and possible role of IGSF4 gene in colorectal carcinogenesis of microsatellite instable tumors.
Cancer investigation 2010 Jan 28 (1): 94-102. PMID: 19995226

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CADM1 / SYNCAM antibody

AP21519PU-N CADM1 Antibody staining of Mouse Heart lysate at 0.1 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Rt E, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

CADM1 / SYNCAM antibody

AP32802PU-N CADM1 / SYNCAM Antibody staining of Human Colorectal cancer lysate at 1 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Rt E, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

CADM1 / SYNCAM antibody

  Rabbit Polyclonal CADM1 Antibody  
Western Blot: synCAM Antibody - WB in rat brain and HEK cell lysates showing different glycosylation patterns. Brain fractions give banding patterns of a core glycosylation population around 50kDa and a slightly higher glycosylated population around 65 kDa.  The heterologous HEK cell lysates give a single, fully glycosylated, band around 107kDa. Rabbit Purified Hu, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CADM1 / SYNCAM antibody

  Goat Anti-CADM1/TSLC1 Antibody  
(1ug/ml) staining of Mouse fetal Heart lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Por, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CADM1 / SYNCAM antibody

  Rabbit polyclonal anti-CADM1 antibody  
Western blot analysis of extracts from HeLa cells, using CADM1 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CADM1 / SYNCAM antibody

  Rabbit anti-CADM1 Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using CADM1 antibody. Rabbit IgG Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CADM1 / SYNCAM antibody

Adult whole rat brain homogenate immunoblot Mouse IgG1 L45/30 Supernatant Hu, Ms, Rt ICC/IF, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

CADM1 / SYNCAM antibody

Adult whole rat brain homogenate immunoblot Mouse IgG1 L45/30 Purified Hu, Ms, Rt ICC/IF, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

CADM1 / SYNCAM (C-term) antibody

Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Purified Hu, Ms E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CADM1 / SYNCAM (N-term) antibody

CADM1 antibody (N-term) (Cat. #AP50711PU-N) immunohistochemistry analysis in formalin fixed and paraffin embedded human lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CADM1 antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CADM1 / SYNCAM antibody

Western blot analysis of extracts from HeLa cells, using CADM1 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, WB
50 µg / €230.00
  Assay Biotech

CADM1 / SYNCAM antibody

Western blot analysis of extracts from HeLa cells, using CADM1 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

CADM1 - human gene knockout kit via CRISPR

CADM1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

CADM1 - human gene knockout kit via CRISPR

CADM1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

CADM1 - human gene knockout kit via CRISPR

CADM1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

CADM1 - human gene knockout kit via CRISPR

CADM1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cadm1 - mouse gene knockout kit via CRISPR

Cadm1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CADM1 / SYNCAM (transcript variant 1)

  Recombinant protein of human cell adhesion molecule 1 (CADM1), transcript variant 1  
CADM1 / SYNCAM Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

CADM1 / SYNCAM (45-374, His-tag)

CADM1 / SYNCAM Human Purified > 85 % by SDS - PAGE E. coli
0.1 mg / €730.00
  Acris Antibodies GmbH

CADM1 / SYNCAM (45-374, His-tag)

CADM1 / SYNCAM Human Purified > 85 % by SDS - PAGE E. coli
20 µg / €300.00
  Acris Antibodies GmbH

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