CALHM1 / FAM26C antibody
Principal name
CALHM1 / FAM26C antibody
Alternative names for CALHM1 / FAM26C antibody
Calcium homeostasis modulator protein 1
SwissProt ID
Q8IU99 (Human)
Gene ID
255022 (CALHM1)
Ncbi ID
Available reactivities
Available hosts
Available applications
Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Enzyme Immunoassay (E)
Background of CALHM1 / FAM26C antibody
A misbalance in Ca2+ homeostasis seems to be related to the development of Alzheimerâ??s disease (AD). Indeed Neurol Ca2+ balance may affect the levels of proteins associated with AD, such as amyloid-beta (Ab) and tau. Calcium homeostasis modulator 1 (CALHM1) is a cerebral Ca2+ channel component responsible for controlling intracellular Ca2+ levels and Ab metabolism. CALHM1 is a three transmembrane glycoprotein, mostly localized to the endoplasmic reticulum (ER) although it can be detected at the plasma membrane. A functiol channel is formed by multiple subunits which has some structural similarities to the NMDA receptor. It is expressed in all brain regions. In cultured cells, overexpression of CALHM1 increases intracellular Ca2+ levels and reduces Ab accumulation, thereby reinforcing its implication in the development of AD. Indeed, a polymorphism in the gene was found to affect the onset of AD.





Primary Antibodies
Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
---|---|---|---|---|---|---|---|
TA306919 | CALHM1 / FAM26C antibody |
||||||
Rabbit Polyclonal CALHM1 Antibody | |||||||
![]() |
Rabbit | IgG | Aff - Purified | Hu, Ms, Rt | E, ICC/IF, P, WB |
0.1 mg /
€371.00
|
|
OriGene Technologies, Inc. | |||||||
![]() |
|||||||
TA328697 | CALHM1 / FAM26C antibody |
||||||
Rabbit Polyclonal Anti-Calcium Homeostasis Modulator 1 | |||||||
![]() |
Rabbit | Purified | Hu, Ms, Rt | WB |
0.2 ml /
€622.00
|
||
OriGene Technologies, Inc. | |||||||
![]() |
|||||||
TA590770 | CALHM1 / FAM26C antibody |
||||||
Rabbit Polyclonal CALHM1 Antibody | |||||||
![]() |
Rabbit | IgG | Purified | Hu | WB |
50 µg /
€409.00
|
|
OriGene Technologies, Inc. |
CRISPR
Catalog No. | Species | Donor Vector | |
---|---|---|---|
KN206902 | CALHM1 - human gene knockout kit via CRISPR |
||
![]() |
Human | GFP-Puro |
1 kit /
€1,290.00
|
OriGene Technologies, Inc. | |||
KN206902BN | CALHM1 - human gene knockout kit via CRISPR |
||
![]() |
Human | mBFP-Neo |
1 kit /
€1,290.00
|
OriGene Technologies, Inc. | |||
KN206902LP | CALHM1 - human gene knockout kit via CRISPR |
||
![]() |
Human | Luciferase-Puro |
1 kit /
€1,290.00
|
OriGene Technologies, Inc. | |||
KN206902RB | CALHM1 - human gene knockout kit via CRISPR |
||
![]() |
Human | RFP-BSD |
1 kit /
€1,290.00
|
OriGene Technologies, Inc. |
Lysates
Catalog No. | ||
---|---|---|
LY424341 | CALHM1 overexpression lysate |
|
![]() |
0.1 mg /
€295.00
|
|
OriGene Technologies, Inc. |