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CALHM1 / FAM26C antibody

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Principal name

CALHM1 / FAM26C antibody

Alternative names for CALHM1 / FAM26C antibody

Calcium homeostasis modulator protein 1

SwissProt ID

Q8IU99 (Human)

Gene ID

255022 (CALHM1)

Ncbi ID

NP_001001412.3, ADZ15984.1, NM_001001412, NP_001001412

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Enzyme Immunoassay (E)

Background of CALHM1 / FAM26C antibody

A misbalance in Ca2+ homeostasis seems to be related to the development of Alzheimerâ??s disease (AD). Indeed Neurol Ca2+ balance may affect the levels of proteins associated with AD, such as amyloid-beta (Ab) and tau. Calcium homeostasis modulator 1 (CALHM1) is a cerebral Ca2+ channel component responsible for controlling intracellular Ca2+ levels and Ab metabolism. CALHM1 is a three transmembrane glycoprotein, mostly localized to the endoplasmic reticulum (ER) although it can be detected at the plasma membrane. A functiol channel is formed by multiple subunits which has some structural similarities to the NMDA receptor. It is expressed in all brain regions. In cultured cells, overexpression of CALHM1 increases intracellular Ca2+ levels and reduces Ab accumulation, thereby reinforcing its implication in the development of AD. Indeed, a polymorphism in the gene was found to affect the onset of AD.

TA590770 - CALHM1 / FAM26C
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CALHM1 (RC206902, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CALHM1.
TA306919 - CALHM1 / FAM26C
Western blot analysis of CALHM1 in rat liver tissue lysate with CALHM1 antibody at (A) 1 and (B) 2 ug/mL.
TA306919 - CALHM1 / FAM26C
Immunohistochemistry of CALHM1 in rat liver tissue with CALHM1 antibody at 5 ug/mL.
TA306919 - CALHM1 / FAM26C
Immunofluorescence of CALHM1 in Rat Liver cells with CALHM1 antibody at 20 ug/mL.
TA328697 - CALHM1 / FAM26C
Western blot analysis of rat brain (lanes 1 and 4), mouse brain (lanes 2 and 5), U-87 MG (lanes 3 and 6) and C6 (lanes 4 and 8) lysates: 1. Anti-Calcium Homeostasis Modulator 1 antibody, (1:200). 2. Anti-Calcium Homeostasis Modulator 1 antibody, preincubated with the control peptide antigen.
TA328697 - CALHM1 / FAM26C
Expression of Calcium Homeostasis Modulator 1 in rat hippocampus. Immunohistochemical staining of rat hippocampus using Anti-Calcium Homeostasis Modulator 1 antibody. A. Staining of Calcium Homeostasis Modulator 1 appears only in the hippocampal CA1 pyramidal layer (red). B. Nuclear staining using DAPI as the counterstain (blue). C. Merge of A and B.
CPA9261-100ul - CALHM1 / FAM26C
Western blot analysis of CALHM1 expression in human brain (A); rat brain (B) whole cell lysates.
CPA9261-100ul - CALHM1 / FAM26C
Immunohistochemical analysis of CALHM1 staining in human Hepatocancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.

8 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CALHM1 / FAM26C antibody
  Rabbit Polyclonal CALHM1 Antibody  
Western blot analysis of CALHM1 in rat liver tissue lysate with CALHM1 antibody at (A) 1 and (B) 2 ug/mL. Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.
+2 additional images

CALHM1 / FAM26C antibody
  Rabbit Polyclonal Anti-Calcium Homeostasis Modulator 1  
Western blot analysis of rat brain (lanes 1 and 4), mouse brain (lanes 2 and 5), U-87 MG (lanes 3 and 6) and C6 (lanes 4 and 8) lysates: 1. Anti-Calcium Homeostasis Modulator 1 antibody, (1:200). 2. Anti-Calcium Homeostasis Modulator 1 antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.
+1 additional image

CALHM1 / FAM26C antibody
  Rabbit Polyclonal CALHM1 Antibody  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CALHM1 (RC206902, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CALHM1. Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

CRISPR

Catalog No. Species Donor Vector  

CALHM1 - human gene knockout kit via CRISPR
CALHM1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

CALHM1 - human gene knockout kit via CRISPR
CALHM1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

CALHM1 - human gene knockout kit via CRISPR
CALHM1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

CALHM1 - human gene knockout kit via CRISPR
CALHM1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

CALHM1 overexpression lysate
CALHM1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

8 Item(s)

per page

Available Filters

Product Type
  1. CRISPR (4)
  2. Lysate (1)
  3. Primary Antibody (3)
Clonality
  1. Polyclonal (3)
Target
  1. CALHM1 / FAM26C (3)
Reactivity
  1. Human (Hu) (3)
  2. Mouse (Ms) (2)
  3. Rat (Rt) (2)
Applications
  1. Western blot / Immunoblot (WB) (3)
  2. Enzyme Immunoassay (E) (1)
  3. Immunocytochemistry/​Immunofluorescence (ICC/IF) (1)
  4. Paraffin Sections (P) (1)
Presentation
  1. Purified (2)
  2. Aff - Purified (1)
Host
  1. Rabbit (3)
Images
  1. 1 image (3)
  2. 3+ images (1)
Images: Applications
  1. Western blot / Immunoblot (WB) (3)
  2. IHC (2)
  3. Immunofluorescence (IF) (1)
Species (CRISPR)
  1. Human (4)
Donor Vector
  1. GFP-Puro (1)
  2. Luciferase-Puro (1)
  3. RFP-BSD (1)
  4. mBFP-Neo (1)
Manufacturer
  1. Acris - OriGene (8)
Service
  • OriGene EU
  • Acris Antibodies GmbH
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  • D-32052 Herford
  • Germany
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  • free call: 0800-227 47 46 (Germany only)
  • fax: +49-5221-34606-11
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