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Calpain-6 antibody

Principal name

Calpain-6 antibody

Alternative names for Calpain-6 antibody

Calpamodulin, CAPN6, CALPM, CANPX, Calpain-like protease X-linked

SwissProt ID

O35646 (Mouse), O88501 (Rat), Q9Y6Q1 (Human)

Gene ID

827 (CAPN6), 83685 (Capn6)

Ncbi ID

9606, NP_055104.2, NP_055104, 10090, NM_014289, NM_031808

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit

Available applications

Frozen Sections (C), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunohistochemistry (IHC), Enzyme Immunoassay (E)

Background of Calpain-6 antibody

Calpains make up a ubiquitously expressed, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. This large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes as their activation can be triggered by calcium influx and oxidative stress. Calpain 6 (CAPN6) is most similar to Calpain 5; the C-terminal region of CAPN6 lacks homology to the calmodulin-like domain of other vertebrate calpains. CAPN6 is thought to be involved in the regulation of microtubule dynamics and cytoskeletal organization. CAPN6 has also been recently identified as an HIV dependency factor (HDF), suggesting that CAPN6 may be an important drug target in HIV treatment.

Western blot analysis of extract from NIH/3T3 cells, using CAPN6 polyclonal antibody ( Cat # PAB8485 ) .

PAB8485

Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)

AP23471PU-N

Western blot analysis of CAPN6 in rat lung tissue lysate with CAPN6 antibody at (A) 0.5 and (B) 1 µg/ml.

AP23471PU-N

CAPN6 Antibody (Center) (Cat. #AP50726PU-N)immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CAPN6 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.

AP50726PU-N

CAPN6 Antibody (Center) (Cat. #AP50726PU-N) western blot analysis in HL-60 cell line lysates (35µg/lane).This demonstrates the CAPN6 antibody detected the CAPN6 protein (arrow).

AP50726PU-N

TP300539

Western blot analysis of CAPN6 in rat lung tissue lysate with CAPN6 antibody at (A) 0.5 and (B) 1 ug/ml.

TA306628

Immunohistochemistry of CAPN6 in human lung tissue with CAPN6 antibody at 2.5 ug/ml.

TA306628

Immunofluorescence of CAPN6 in Human Lung cells with CAPN6 antibody at 20 ug/mL.

TA306628

Predicted cell location: Cytoplasm, Nucleus. Positive control: Human esophagus cancer tissue. Recommended dilution: 1/25-100 The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CAPN6 antibody at dilution 1/15, on the right is treated with the fusion protein. (Original magnification: x200)

TA322386

Primary Antibodies

Catalog No.	Host	Iso.	Pres.	React.	Applications
TA322386	Calpain-6 antibody
	Anti-CAPN6 Rabbit Polyclonal Antibody
	Rabbit	IgG	Purified	Hu, Ms, Rt	E, P	0.1 ml / €335.00
						OriGene Technologies, Inc.

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