Calpain-6 antibody
Principal name
Calpain-6 antibody
Alternative names for Calpain-6 antibody
Calpamodulin, CAPN6, CALPM, CANPX, Calpain-like protease X-linked
Available reactivities
Available hosts
Available applications
Frozen Sections (C), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunohistochemistry (IHC), Enzyme Immunoassay (E)
Background of Calpain-6 antibody
Calpains make up a ubiquitously expressed, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. This large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes as their activation can be triggered by calcium influx and oxidative stress. Calpain 6 (CAPN6) is most similar to Calpain 5; the C-terminal region of CAPN6 lacks homology to the calmodulin-like domain of other vertebrate calpains. CAPN6 is thought to be involved in the regulation of microtubule dynamics and cytoskeletal organization. CAPN6 has also been recently identified as an HIV dependency factor (HDF), suggesting that CAPN6 may be an important drug target in HIV treatment.
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| TA322386 | Calpain-6 antibody |
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| Anti-CAPN6 Rabbit Polyclonal Antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms, Rt | E, P |
0.1 ml /
€335.00
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| OriGene Technologies, Inc. | |||||||
