Calpain-6 antibody

Principal name

Calpain-6 antibody

Alternative names for Calpain-6 antibody

Calpamodulin, CAPN6, CALPM, CANPX, Calpain-like protease X-linked

SwissProt ID

O35646 (Mouse), O88501 (Rat), Q9Y6Q1 (Human)

Gene ID

827 (CAPN6), 83685 (Capn6)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit

Available applications

Frozen Sections (C), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunohistochemistry (IHC), Enzyme Immunoassay (E)

Background of Calpain-6 antibody

Calpains make up a ubiquitously expressed, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. This large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes as their activation can be triggered by calcium influx and oxidative stress. Calpain 6 (CAPN6) is most similar to Calpain 5; the C-terminal region of CAPN6 lacks homology to the calmodulin-like domain of other vertebrate calpains. CAPN6 is thought to be involved in the regulation of microtubule dynamics and cytoskeletal organization. CAPN6 has also been recently identified as an HIV dependency factor (HDF), suggesting that CAPN6 may be an important drug target in HIV treatment.

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Lysates

Catalog No.    

CAPN6 overexpression lysate

CAPN6 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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