Calsenilin antibody

Principal name

Calsenilin antibody

Alternative names for Calsenilin antibody

KCNIP3, CSEN, DREAM, KCHIP3, DRE-antagonist modulator, A-type potassium channel modulatory protein 3, Kv channel-interacting protein 3

SwissProt ID

Q17QD9 (Bovin), Q9JM47 (Rat), Q9QXT8 (Mouse), Q9Y2W7 (Human)

Gene ID

30818 (KCNIP3), 65199 (Kcnip3), 56461

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Chk (Chicken), Ms (Mouse), Por (Porcine), Rt (Rat), Ze (Zebrafish), African clawed frog

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), EPair for Elisa (EPair), Immunoprecipitation (IP), Frozen Sections (C)

Background of Calsenilin antibody

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces.
There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligandgated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inwardrectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels. There are four member of the KChiPs (Kv4 potassium channel interacting protein) family. They are all EF handcontaining proteins required for the traffic of channelforming Kv4 K+ subunits to the plasma membrane.
KChiP3 is also known as calsenilin and as the transcription factor, downstream regulatory element antagonist modulator (DREAM), which regulates a number of genes including prodynorphon. They are highly expressed in the hippocampus. Through its various functions, it may play a role in the regulation of synaptic plasticity, learning and memory.

General readings

Zaidi,N.F., et al., (2004) J. Neurochem. 89 (3), 593-601

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Calsenilin (N-term) antibody

Formalin-fixed and paraffin-embedded human brain tissue reacted with KChIP3 Antibody (N-term) (AP11608PU-N), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu, Ms E, ICC/IF, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Calsenilin (N-term) antibody


HEK293 lysate (10 µg protein in RIPA buffer) overexpressing Human KCNIP3 with C-terminal MYC tag probed with KCNIP3 antibody Cat.-No AP31985PU-N at 1 µg/ml in Lane A and probed with anti-MYC Tag (1/1000) in Lane C. Mock-transfected HEK293 probed with AP31985PU-N (1 mg/ml) in Lane B. Primary incubations were for 1 hour. Detected by chemiluminescence.
Goat Aff - Purified Bov, Can, Hu E, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Calsenilin antibody

HEK293 lysate (10 µg protein in RIPA buffer) overexpressing Human KCNIP3 with C-terminal MYC tag probed with KCNIP3 antibody Cat.-No AP31991PU-N at 1 µg/ml in Lane A and probed with anti-MYC Tag (1/1000) in lane C. Mock-transfected HEK293 probed with AP31991PU-N (1 mg/ml) in Lane B. Primary incubations were for 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu E, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Calsenilin antibody

  Mouse Monoclonal Anti-KChiP3 Antibody  
IHC analysis of KChIP3 in frozen sections of mouse brain extract using the antibody Mouse IgG2a S66-38 Purified Hu, Ms, Rt C, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Calsenilin antibody

  Rabbit polyclonal Anti-KChIP3  
Western blot analysis of human T-cell lymphoma Jurkat cell lysates (lanes 1 and 4), mouse heart lysate (lanes 2 and 5) and rat brain lysates (lanes 3 and 6): 1-3. Anti-KChIP3 antibody , (1:200). 4-6. Anti-KChiP3 antibody, preincubated with the control peptide antigen Rabbit Purified Hu, Ms, Rt WB
50 µl / €325.00
  OriGene Technologies, Inc.

Calsenilin antibody

  Rabbit Polyclonal Anti-CSEN Antibody  
WB Suggested Anti-CSEN Antibody Titration: 0.2-1 ug/ml; Positive Control: Jurkat cell lysate Rabbit IgG Purified Hu P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Calsenilin antibody

  Rabbit Polyclonal Anti-Calsenilin/KCNIP3 Antibody  
Western blot analysis of Calsenilin/KCNIP3 expression in A431 cells Rabbit IgG Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Calsenilin antibody

  Rabbit Polyclonal Anti-Calsenilin/KCNIP3 Antibody  
Western blot analysis of Calsenilin/KCNIP3 expression in A431 cells Rabbit IgG Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Calsenilin antibody

Immunoblot versus crude membranes from adult rat brain (RBM) and WT and KChIP3 KO mouse brains probed with K66/38 (left) and K55/82 (right) TC supe. Mouse samples courtesy of Takeshi Sakurai and Joseph Buxbaum (Mount Sinai School of Medicine). Mouse IgG2a K66/38 Supernatant Hu, Ms, Rt C, ICC/IF, IP, WB
5 ml / €460.00
  Antibodies Incorporated

NeuroMab

Calsenilin antibody

Immunoblot versus crude membranes from adult rat brain (RBM) and WT and KChIP3 KO mouse brains probed with K66/38 (left) and K55/82 (right) TC supe. Mouse samples courtesy of Takeshi Sakurai and Joseph Buxbaum (Mount Sinai School of Medicine). Mouse IgG2a K66/38 Purified Hu, Ms, Rt C, ICC/IF, IP, WB
0.1 ml / €540.00
  Antibodies Incorporated

NeuroMab

Calsenilin pSer63 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using Calsenilin/KCNIP3 (Phospho-Ser63) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, ICC/IF, P, WB
50 µg / €230.00
  Assay Biotech

Calsenilin pSer63 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using Calsenilin/KCNIP3 (Phospho-Ser63) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, ICC/IF, P, WB
0.1 mg / €330.00
  Assay Biotech

Calsenilin antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Calsenilin/KCNIP3 (Ab-63) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, ICC/IF, P, WB
50 µg / €230.00
  Assay Biotech

Calsenilin antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Calsenilin/KCNIP3 (Ab-63) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, ICC/IF, P, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

KCNIP3 - human gene knockout kit via CRISPR

KCNIP3 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

KCNIP3 - human gene knockout kit via CRISPR

KCNIP3 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

KCNIP3 - human gene knockout kit via CRISPR

KCNIP3 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Calsenilin (transcript variant 1)

  Recombinant protein of human Kv channel interacting protein 3, calsenilin (KCNIP3), transcript variant 1  
Calsenilin Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

Calsenilin (transcript variant 2)

  Recombinant protein of human Kv channel interacting protein 3, calsenilin (KCNIP3), transcript variant 2  
Calsenilin Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Calsenilin (1-256, His-tag)

Recombinant human KCNIP3, 1-256 aa, His-tagged Human Purified > 90 % E. coli
0.5 mg / €750.00
  Acris Antibodies GmbH

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