Calsenilin antibody

Principal name

Calsenilin antibody

Alternative names for Calsenilin antibody

KCNIP3, CSEN, DREAM, KCHIP3, DRE-antagonist modulator, A-type potassium channel modulatory protein 3, Kv channel-interacting protein 3

SwissProt ID

Q17QD9 (Bovin), Q9JM47 (Rat), Q9QXT8 (Mouse), Q9Y2W7 (Human)

Gene ID

30818 (KCNIP3), 56461 (Kcnip3), 65199

Available reactivities

Hu (Human), Ms (Mouse), Rb (Rabbit), Rt (Rat), Bov (Bovine), Can (Canine), Chk (Chicken), Por (Porcine), Ze (Zebrafish), African clawed frog

Available hosts

Rabbit, Mouse, Goat

Available applications

Frozen Sections (C), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), ELISA (detection) (E(detection)), EPair for Elisa (EPair), Immunoprecipitation (IP)

Background of Calsenilin antibody

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces.
There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligandgated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inwardrectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels. There are four member of the KChiPs (Kv4 potassium channel interacting protein) family. They are all EF handcontaining proteins required for the traffic of channelforming Kv4 K+ subunits to the plasma membrane.
KChiP3 is also known as calsenilin and as the transcription factor, downstream regulatory element antagonist modulator (DREAM), which regulates a number of genes including prodynorphon. They are highly expressed in the hippocampus. Through its various functions, it may play a role in the regulation of synaptic plasticity, learning and memory.

General readings

Zaidi,N.F., et al., (2004) J. Neurochem. 89 (3), 593-601

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Calsenilin (N-term) antibody

Formalin-fixed and paraffin-embedded human brain tissue reacted with KChIP3 Antibody (N-term) (AP11608PU-N), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu, Ms E, ICC/IF, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Calsenilin (N-term) antibody


HEK293 lysate (10 µg protein in RIPA buffer) overexpressing Human KCNIP3 with C-terminal MYC tag probed with KCNIP3 antibody Cat.-No AP31985PU-N at 1 µg/ml in Lane A and probed with anti-MYC Tag (1/1000) in Lane C. Mock-transfected HEK293 probed with AP31985PU-N (1 mg/ml) in Lane B. Primary incubations were for 1 hour. Detected by chemiluminescence.
Goat Aff - Purified Bov, Can, Hu E, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Calsenilin antibody

HEK293 lysate (10 µg protein in RIPA buffer) overexpressing Human KCNIP3 with C-terminal MYC tag probed with KCNIP3 antibody Cat.-No AP31991PU-N at 1 µg/ml in Lane A and probed with anti-MYC Tag (1/1000) in lane C. Mock-transfected HEK293 probed with AP31991PU-N (1 mg/ml) in Lane B. Primary incubations were for 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu E, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Calsenilin antibody

Western Blot: CSEN Antibody - Western blot analysis of huDREAM in transfected HEK293 cells with anti-huDREAM at a 1:500 dilution. Rabbit Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Calsenilin antibody

IHC analysis of KChIP3 in frozen sections of mouse brain extract using the antibody Mouse IgG2a S66-38 Purified Hu, Ms, Rt C, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Calsenilin antibody

Western blot analysis of human T-cell lymphoma Jurkat cell lysates (lanes 1 and 4), mouse heart lysate (lanes 2 and 5) and rat brain lysates (lanes 3 and 6): 1-3. Anti-KChIP3 antibody , (1:200). 4-6. Anti-KChiP3 antibody, preincubated with the control peptide antigen Rabbit Purified Hu, Ms, Rt WB
50 µl / €325.00
  OriGene Technologies, Inc.

Calsenilin antibody

WB Suggested Anti-CSEN Antibody Titration: 0.2-1 ug/ml; Positive Control: Jurkat cell lysate Rabbit IgG Purified Hu P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Calsenilin antibody

Western blot analysis of Calsenilin/KCNIP3 expression in A431 cells Rabbit IgG Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Calsenilin antibody

Western blot analysis of Calsenilin/KCNIP3 expression in A431 cells Rabbit IgG Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Calsenilin antibody

Immunoblot versus crude membranes from adult rat brain (RBM) and WT and KChIP3 KO mouse brains probed with K66/38 (left) and K55/82 (right) TC supe. Mouse samples courtesy of Takeshi Sakurai and Joseph Buxbaum (Mount Sinai School of Medicine). Mouse IgG2a K66/38 Supernatant Hu, Ms, Rt C, ICC/IF, IP, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

Calsenilin antibody

Immunoblot versus crude membranes from adult rat brain (RBM) and WT and KChIP3 KO mouse brains probed with K66/38 (left) and K55/82 (right) TC supe. Mouse samples courtesy of Takeshi Sakurai and Joseph Buxbaum (Mount Sinai School of Medicine). Mouse IgG2a K66/38 Purified Hu, Ms, Rt C, ICC/IF, IP, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

Calsenilin (1-256) antibody

Immunohistochemistry analysis of KChIP3 in Frozen Sections of Mouse brain extract using Calsenilin Antibody Cat.-No AM20103PU-N (Clone S66-38) Mouse IgG2a S66-38 Purified Hu, Ms, Rt C, ICC/IF, IP, WB
0.1 mg / €380.00
  Acris Antibodies GmbH

Calsenilin antibody

Calsenilin Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Calsenilin antibody

CSEN MaxPab polyclonal antibody. Western Blot analysis of CSEN expression in rat brain. Mouse Purified Hu, Rt E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

Calsenilin antibody

Western Blot analysis of KCNIP3 expression in transfected 293T cell line (H00030818-T01) by KCNIP3 MaxPab polyclonal antibody.

Lane 1: KCNIP3 transfected lysate(29.20 KDa).
Lane 2: Non-transfected lysate. Rabbit Serum Hu, Ms E(detection), IP, WB
0.1 ml / €380.00
  Abnova Taiwan Corp.

Calsenilin antibody

KCNIP3 MaxPab rabbit polyclonal antibody. Western Blot analysis of KCNIP3 expression in mouse liver. Rabbit Purified Hu, Ms E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

Calsenilin antibody

Immunofluorescence of monoclonal antibody to CSEN on HeLa cell . [antibody concentration 10 ug/ml] Mouse IgG1 2B3-A1 Purified Hu E, ICC/IF, WB
50 µg / €370.00
  Abnova Taiwan Corp.

Calsenilin antibody

Calsenilin Mouse IgG1 2B3-A1 Ascites Hu E, WB
0.2 ml / €370.00
  Abnova Taiwan Corp.

Calsenilin antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with KCNIP3 polyclonal antibody ( Cat # PAB3618 ) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma. Rabbit Hu, Ms E, P
0.4 ml / €390.00
  Abnova Taiwan Corp.

Calsenilin antibody

Western blot analysis of KCNIP3 expression in Jurkat cell lysate. Rabbit Hu, Ms, Rt WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

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