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Carboxypeptidase N catalytic chain antibody

Principal name

Carboxypeptidase N catalytic chain antibody

Alternative names for Carboxypeptidase N catalytic chain antibody

CPN, CPN1, ACBP, Kininase-1, Serum carboxypeptidase N, Anaphylatoxin inactivator, Plasma carboxypeptidase B, Lysine carboxypeptidase, Arginine carboxypeptidase, SCPN, Carboxypeptidase N polypeptide 1, Carboxypeptidase N small subunit

SwissProt ID

P15169 (Human), Q2KJ83 (Bovin), Q9EQV8 (Rat), Q9JJN5 (Mouse)

Gene ID

1369 (CPN1), 93721 (Cpn1), 365466

Ncbi ID

9606, NP_001299, NP_001299.1, NM_001308, NP_109628.1, NM_030703, NM_053526

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Chk (Chicken), Dros (Drosophila), Ms (Mouse), Rt (Rat), Ze (Zebrafish), African clawed frog, Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of Carboxypeptidase N catalytic chain antibody

Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency.Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

General readings

Skidgel,R.A. (2007) Int. Immunopharmacol. 7 (14), 1888-1899

AP01465PU-N - Carboxypeptidase N catalytic chain

Western blot (WB) analysis of CPN cat antibody (Cat.-No.: AP01465PU-N) in extracts from RAW264.7 cell

AP01465PU-N

ARP51939_P050 - Carboxypeptidase N catalytic chain

Human Heart; Heart; CPN1 antibody - middle region (ARP51939_P050) in Human Heart cells using Immunohistochemistry

ARP51939_P050

Transfected 293T; WB Suggested Anti-CPN1 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:1562500. Positive Control: Transfected 293T; CPN1 antibody - middle region (ARP51939_P050) in Transfected 293T cells using Western Blot

ARP51939_P050

ARP51940_P050 - Carboxypeptidase N catalytic chain

Transfected 293T; WB Suggested Anti-CPN1 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: Transfected 293T; CPN1 antibody - middle region (ARP51940_P050) in Transfected 293T cells using Western Blot

ARP51940_P050

C14963-1 - Carboxypeptidase N catalytic chain

Western blot analysis of extracts from RAW264.7 cells, using CPN1 Antibody. The lane on the right is treated with the synthesized peptide.

AP51053PU-N - Carboxypeptidase N catalytic chain

Formalin fixed and paraffin embedded human liver tissue stained with CPN1 Antibody (Center) Cat.-No AP51053PU-N followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of CPN1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.

AP51053PU-N

Western blot analysis of CPN1 (arrow) using CPN1 Antibody (Center) Cat.-No AP51053PU-N. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CPN1 gene.

AP51053PU-N

CPA1264-100ul - Carboxypeptidase N catalytic chain

Western blot analysis of Carboxypeptidase N 1 expression in HepG2 (A); HEK293T (B) whole cell lysates.

TP760866 - Carboxypeptidase N catalytic chain

TP760866

TA313681 - Carboxypeptidase N catalytic chain

Western blot analysis of extracts from RAW264.7 cells, using CPN1 antibody.The lane on the right is treated with the synthesized peptide.

TA313681

TA340008 - Carboxypeptidase N catalytic chain

WB Suggested Anti-CPN1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 1562500; Positive Control: Transfected 293T

TA340008

Heart

TA340008

TA340009 - Carboxypeptidase N catalytic chain

WB Suggested Anti-CPN1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: Transfected 293T

TA340009

Primary Antibodies

Catalog No.	Host	Iso.	Pres.	React.	Applications
TA313681	Carboxypeptidase N catalytic chain antibody
	Rabbit polyclonal anti-CPN1 (carboxypeptidase N, polypeptide 1) antibody
	Rabbit	IgG	Purified	Hu	E, WB	0.1 ml / €335.00
						OriGene Technologies, Inc.
TA340008	Carboxypeptidase N catalytic chain antibody
	Rabbit Polyclonal Anti-CPN1 Antibody
	Rabbit	IgG	Purified	Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze	P, WB	50 µg / €360.00
						OriGene Technologies, Inc.
+1 additional image
TA340009	Carboxypeptidase N catalytic chain antibody
	Rabbit Polyclonal Anti-CPN1 Antibody
	Rabbit	IgG	Purified	Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze	WB	50 µg / €360.00
						OriGene Technologies, Inc.
AP01465PU-N	Carboxypeptidase N catalytic chain antibody
	Rabbit		Aff - Purified	Hu	WB	0.1 mg / €350.00
						Acris Antibodies GmbH
AP51053PU-N	Carboxypeptidase N catalytic chain (Center) antibody
	Rabbit	Ig	Purified	Hu	P, WB	0.4 ml / €370.00
						Acris Antibodies GmbH
+1 additional image
C14963-1	Carboxypeptidase N catalytic chain antibody
	Rabbit		Aff - Purified	Hu	E, WB	50 µg / €230.00
						Assay Biotech
C14963-2	Carboxypeptidase N catalytic chain antibody
	Rabbit		Aff - Purified	Hu	E, WB	0.1 mg / €330.00
						Assay Biotech

Proteins & Growth Factors

Catalog No.	Species	Purity	Source
TP760866	Carboxypeptidase N catalytic chain (full length, N-term HIS tag)
	Purified recombinant protein of Human carboxypeptidase N, polypeptide 1 (CPN1), full length, with N-terminal HIS tag, expressed in E. coli, 50ug
	Human	> 80 % Preparation: . Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.	E. coli	50 µg / €199.00
				OriGene Technologies, Inc.

Lysates

Catalog No.
LY420016	CPN1 overexpression lysate
		0.1 mg / €295.00
		OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.
RC206606L2V	Lenti ORF particles, CPN1 (mGFP-tagged) - Human carboxypeptidase N, polypeptide 1 (CPN1), 200 uL, >10^7 TU/mL
		200 µl / €1,082.00
		OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.
MR207305L2V	Lenti ORF particles, Cpn1 (GFP-tagged) - Mouse carboxypeptidase N, polypeptide 1 (Cpn1), 200 uL, >10^7 TU/mL
		200 µl / €1,092.00
		OriGene Technologies, Inc.

MR207305L1V	Lenti ORF particles, Cpn1 (Myc-DDK-tagged) - Mouse carboxypeptidase N, polypeptide 1 (Cpn1), 200 uL, >10^7 TU/mL
		200 µl / €979.00
		OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.
RR201144L2V	Lenti ORF particles, Cpn1 (GFP-tagged ORF) - Rat carboxypeptidase N, polypeptide 1 (Cpn1), 200 uL, >10^7 TU/mL
		200 µl / €1,092.00
		OriGene Technologies, Inc.

RR201144L1V	Lenti ORF particles, Cpn1 (Myc-DDK-tagged ORF) - Rat carboxypeptidase N, polypeptide 1 (Cpn1), 200 uL, >10^7 TU/mL
		200 µl / €979.00
		OriGene Technologies, Inc.

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