Carboxypeptidase N subunit 2 antibody

Principal name

Carboxypeptidase N subunit 2 antibody

Alternative names for Carboxypeptidase N subunit 2 antibody

CPN2, ACBP, Carboxypeptidase N polypeptide 2, Carboxypeptidase N 83 kDa chain, Carboxypeptidase N regulatory subunit, Carboxypeptidase N large subunit

SwissProt ID

P22792 (Human), Q9DBB9 (Mouse)

Gene ID

1370 (CPN2)

Available reactivities

Hu (Human), Bov (Bovine), Ms (Mouse), Rt (Rat), Can (Canine), Eq (Equine), Por (Porcine)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Flow Cytometry (F), Frozen Sections (C)

Background of Carboxypeptidase N subunit 2 antibody

CPN2 is a zinc metalloprotease, and cleaves carboxy-terminal arginines and lysines from peptides found in the bloodstream such as complement anaphylatoxins, kinins, and creatine kinase MM (CK-MM). By removing only one amino acid, CPN has the ability to change peptide activity and receptor binding. It is a 280 kDa tetrameric glycoprotein that is synthesized by the liver and secreted into the plasma. It consists of 2 identical 83 kDa regulatory subunits (CPN2) and 2 identical 50 kDa catalytic subunits (CPN1). CPN2, the 83 kDa subunit, binds and stabilizes the catalytic subunit at 37 degrees Celsius and keeps it in circulation. Under some circumstances it may be an allosteric modifier of the catalytic subunit. CPN is a member of a larger family of carboxypeptidases, many of which also cleave arginine and lysine. Because of the highly conserved active sites and the possible redundant functions of carboxypeptidases, it has been difficult to elucidate the role of CPN in disease processes.

General readings

Liu,T., (2005) J. Proteome Res. 4 (6), 2070-2080

9 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Carboxypeptidase N subunit 2 antibody

Western blot analysis of extracts from HeLa cells, using CPN2 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Carboxypeptidase N subunit 2 antibody

1Hum. Adult Placenta; Host: Rabbit; Target Name: CHAD; Sample Tissue: Human Adult Placenta; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

Carboxypeptidase N subunit 2 antibody

Carboxypeptidase N subunit 2 Mouse IgG1 36A1 Hu E, WB
0.1 ml / €390.00
  Abnova Taiwan Corp.

Carboxypeptidase N subunit 2 antibody

Hum. Adult Placenta; Host: Rabbit. Target Name: CHAD . Sample Tissue: Human Adult Placenta . Antibody Dilution: 1.0ug/ml.; CPN2 antibody - N-terminal region (ARP51877_P050) in Hum. Adult Placenta cells using Western Blot Rabbit Aff - Purified Bov, Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

Carboxypeptidase N subunit 2 antibody

Western blot analysis of Carboxypeptidase N 2 expression in MCF7 (A); HeLa (B); Raw264.7 (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

Carboxypeptidase N subunit 2 antibody

Western blot analysis of Carboxypeptidase N 2 expression in MCF7 (A); HeLa (B); Raw264.7 (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

Carboxypeptidase N subunit 2 antibody

Western blot analysis of Carboxypeptidase N 2 expression in MCF7 (A); HeLa (B); Raw264.7 (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

Carboxypeptidase N subunit 2 antibody

Immunohistochemistry-Paraffin: CPN2 Antibody [NBP1-90873] - Immunohistochemical staining of human hippocampus shows strong nuclear positivity in neuronal and glial cells. Rabbit Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Lysates

Catalog No.    

CPN2 overexpression lysate

CPN2 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

9 Item(s)

per page
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