CARD15 / NOD2 antibody

Principal name

CARD15 / NOD2 antibody

Alternative names for CARD15 / NOD2 antibody

IBD1, Nucleotide-binding oligomerization domain-containing protein 2,Caspase recruitment domain-containing protein 15, Inflammatory bowel disease protein 1

SwissProt ID

Q8K3Z0 (Mouse), Q9HC29 (Human)

Gene ID

64127 (NOD2), 257632 (Nod2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Goat, Rat, Mouse

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Frozen Sections (C), Immunoprecipitation (IP), Paraffin Sections (P), Enzyme Immunoassay (E), ELISA (detection) (E(detection))

Background of CARD15 / NOD2 antibody

Nod2, also known as caspase recruitment domain-containing protein 15, CARD15, and inflammatory bowel disease protein 1, is a monocyte-specific cytoplasmic protein containing two N-terminal caspase recruitment domains (CARD domains), and multiple leucine-rich repeats with a predicted molecular weight 115 kD. Alternative initiation produces two isoforms of Nod2. Nod2 is thought to confer responsiveness to intracellular bacterial lipopolysaccharide (LPS), and defects in Nod2 have been linked to several diseases including Blau syndrome, Crohns's disease, and ulcerative colitis. Knock-out animals has been shown to have dramatically altered responses to bacterial pathogens in the gut. Nod2 binds to the receptor interacting kinase 1 protein via CARD-CARD interaction and induces NF-κB and IKK-gamma. 
Structure: Cytoplasmic protein containing two N-terminal caspase recruitment domains (CARD domains), multiple leucine-rich repeats, predicted molecular weight 115 kD. Alternative initiation produces two isoforms.
Distribution: Monocyte-specific.
Function: Confers responsiveness to intracellular bacterial lipopolysaccharide (LPS). Binds to RIP2 via CARD-CARD interaction and induces NF-κB and IKK-gamma. Defects in Nod1 are associated with Blau syndrome, Crohn's disease, and ulcerative colitis.
Interaction: RIP2, CARD12.

16 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CARD15 / NOD2 antibody

  Goat Polyclonal Antibody against CARD15  
TA303142 (0.1µg/ml) staining of Human Peripheral Blood Mononucleocyte lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CARD15 / NOD2 (N-term) antibody

  Rabbit Polyclonal NOD2 Antibody  
Western blot analysis of NOD2 in Jurkat cell lysate with NOD2 antibody at (A) 1, (B) 2 and (C) 4 ug/mL. Rabbit IgG Aff - Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CARD15 / NOD2 (C-term) antibody

  Rabbit Polyclonal NOD2 Antibody  
Western blot analysis of NOD2 in HeLa cell lysate with NOD2 antibody at (A) 2 and (B) 4 ug/mL. Rabbit IgG Aff - Purified Hu E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CARD15 / NOD2 antibody

  Rat Anti-Mouse NOD2 Purified (50 ug)  
Immunoblot of HEK 293T cell control lysate (lane 1) and HEK 293T cells transfected with Mouse NOD2 (lane 2).  The blots were probed with 2 ug/ml of Anti-Mouse NOD2 Purified followed by Anti-Rat HRP and visualized by chemiluminescence. Rat 26mNOD2 Purified Ms WB
50 µg / €120.00
  OriGene Technologies, Inc.

CARD15 / NOD2 antibody

  Mouse Monoclonal anti-Nod2 Antibody  
Cell extract from MCF-7 cells transfected with either human Nod1 (Lane 1) or human Nod2 (Lane 2) was resolved by electrophoresis, transferred to nitrocellulose, and probed with monoclonal anti-Nod2 antibody (clone NOD-15). Proteins were visualized using a goat anti-mouse secondary conjugated to HRP and a chemiluminescence detection system. The NOD-15 antibody is specific for human Nod2 and does not cross-react with human Nod1. Mouse IgG2a NOD-15 Aff - Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CARD15 / NOD2 antibody

  Rabbit Polyclonal NOD2 Antibody  
Western Blot: NOD2 Antibody [TA336664] - Detection of NOD2 in 20ug of NOD2 transfected 293T cell lysate using NB 500-253.  ECL detection in 15 seconds. Rabbit Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CARD15 / NOD2 antibody

  Rabbit Polyclonal Anti-NOD2 Antibody  
CARD15 / NOD2 Rabbit IgG Purified Hu E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CARD15 / NOD2 antibody

  Mouse Monoclonal anti-Nod2 Antibody  
Cell extract from MCF-7 cells transfected with either human Nod1 (Lane 1) or human Nod2 (Lane 2) was resolved by electrophoresis, transferred to nitrocellulose, and probed with monoclonal anti-Nod2 antibody (clone NOD-15). Proteins were visualized using a goat anti-mouse secondary conjugated to HRP and a chemiluminescence detection system. The NOD-15 antibody is specific for human Nod2 and does not cross-react with human Nod1. Mouse NOD-15 Purified Hu WB
25 µg / €248.00
  OriGene Technologies, Inc.

CARD15 / NOD2 antibody

Mouse Lymph Node: Formalin-Fixed, Paraffin-Embedded (FFPE) Rat IgG1 26mNOD2 Aff - Purified Ms P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CARD15 / NOD2 (C-term) antibody

Immunocytochemical staining of HeLa cells with Rabbit anti Human NOD2 (AP05557PU-N) Rabbit IgG Purified Hu ICC/IF, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

CARD15 / NOD2 (C-term) antibody

Immunocytochemical staining of HeLa cells with Rabbit anti Human NOD2 (AP05557PU-N) Rabbit IgG Purified Hu ICC/IF, WB
50 µg / €300.00
  Acris Antibodies GmbH

CARD15 / NOD2 antibody

Small intestine: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu E, ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CARD15 / NOD2 (C-term) antibody

Small intestine: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu E, ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Lysates

Catalog No.    

NOD2 overexpression lysate

NOD2 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, NOD2 (mGFP-tagged)-Human nucleotide-binding oligomerization domain containing 2 (NOD2), 200 uL, >10^7 TU/mL

Lenti ORF particles, NOD2 (mGFP-tagged)-Human nucleotide-binding oligomerization domain containing 2 (NOD2), 200 uL, >10^7 TU/mL  
200 µl / €2,110.00
  OriGene Technologies, Inc.

Lenti ORF particles, NOD2 (Myc-DDK-tagged)-Human nucleotide-binding oligomerization domain containing 2 (NOD2), 200 uL, >10^7 TU/mL

Lenti ORF particles, NOD2 (Myc-DDK-tagged)-Human nucleotide-binding oligomerization domain containing 2 (NOD2), 200 uL, >10^7 TU/mL  
200 µl / €1,900.00
  OriGene Technologies, Inc.

16 Item(s)

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